Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance
Aim: To study the expression of cathepsin L in nasopharyngeal carcinoma (NPC), and analyze its relationship with clinicopathologic factors.
 Methods: The expression of cathepsin L was determined immunohistochemically in NPC, adjacent normal nasopharyngeal tissues and metastatic
 cerv...
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| Опубліковано в: : | Experimental Oncology |
|---|---|
| Дата: | 2009 |
| Автори: | , , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/135696 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance / X. Xu, G. Yuan, W. Liu, Y. Zhang, W. Chen // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 102-105. — Бібліогр.: 19 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862736105670967296 |
|---|---|
| author | Xu, X. Yuan, G. Liu, W. Zhang, Y. Chen, W. |
| author_facet | Xu, X. Yuan, G. Liu, W. Zhang, Y. Chen, W. |
| citation_txt | Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance / X. Xu, G. Yuan, W. Liu, Y. Zhang, W. Chen // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 102-105. — Бібліогр.: 19 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: To study the expression of cathepsin L in nasopharyngeal carcinoma (NPC), and analyze its relationship with clinicopathologic factors.
Methods: The expression of cathepsin L was determined immunohistochemically in NPC, adjacent normal nasopharyngeal tissues and metastatic
cervical lymph nodes. The correlation between its protein expression and clinicopathologic parameters as well as with long term follow-up data
in NPC was analyzed. Results: The protein of cathepsin L was overexpressed in 47% primary tumor tissues, and in 89% metastatic cervical
lymph node samples. Overexpression of cathepsin L was found to correlate with lymph node metastasis (P = 0.04) and distant metastasis
(P = 0.01), and marginally with clinical stage and T classification, but not with patient age, gender and histological classification of tumor.
Patients with overexpression of cathepsin L in tumor tissue had worse 5-year survival than those without such expression pattern (P= 0.033).
Multivariate survival analysis showed that cathepsin L protein expression level had a marginal significant correlation with prognosis of NPC.
Conclusion: Cathepsin L is a potential biomarker for prognosis of NPC and contributes to NPC metastasis.
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| first_indexed | 2025-12-07T19:52:07Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-135696 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T19:52:07Z |
| publishDate | 2009 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Xu, X. Yuan, G. Liu, W. Zhang, Y. Chen, W. 2018-06-15T13:59:40Z 2018-06-15T13:59:40Z 2009 Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance / X. Xu, G. Yuan, W. Liu, Y. Zhang, W. Chen // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 102-105. — Бібліогр.: 19 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/135696 Aim: To study the expression of cathepsin L in nasopharyngeal carcinoma (NPC), and analyze its relationship with clinicopathologic factors.
 Methods: The expression of cathepsin L was determined immunohistochemically in NPC, adjacent normal nasopharyngeal tissues and metastatic
 cervical lymph nodes. The correlation between its protein expression and clinicopathologic parameters as well as with long term follow-up data
 in NPC was analyzed. Results: The protein of cathepsin L was overexpressed in 47% primary tumor tissues, and in 89% metastatic cervical
 lymph node samples. Overexpression of cathepsin L was found to correlate with lymph node metastasis (P = 0.04) and distant metastasis
 (P = 0.01), and marginally with clinical stage and T classification, but not with patient age, gender and histological classification of tumor.
 Patients with overexpression of cathepsin L in tumor tissue had worse 5-year survival than those without such expression pattern (P= 0.033).
 Multivariate survival analysis showed that cathepsin L protein expression level had a marginal significant correlation with prognosis of NPC.
 Conclusion: Cathepsin L is a potential biomarker for prognosis of NPC and contributes to NPC metastasis. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance Article published earlier |
| spellingShingle | Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance Xu, X. Yuan, G. Liu, W. Zhang, Y. Chen, W. Original contributions |
| title | Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance |
| title_full | Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance |
| title_fullStr | Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance |
| title_full_unstemmed | Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance |
| title_short | Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance |
| title_sort | expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/135696 |
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