Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance
Aim: To study the expression of cathepsin L in nasopharyngeal carcinoma (NPC), and analyze its relationship with clinicopathologic factors. Methods: The expression of cathepsin L was determined immunohistochemically in NPC, adjacent normal nasopharyngeal tissues and metastatic cervical lymph nodes...
Saved in:
| Published in: | Experimental Oncology |
|---|---|
| Date: | 2009 |
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
|
| Subjects: | |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/135696 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance / X. Xu, G. Yuan, W. Liu, Y. Zhang, W. Chen // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 102-105. — Бібліогр.: 19 назв. — англ. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
nasplib_isofts_kiev_ua-123456789-135696 |
|---|---|
| record_format |
dspace |
| spelling |
Xu, X. Yuan, G. Liu, W. Zhang, Y. Chen, W. 2018-06-15T13:59:40Z 2018-06-15T13:59:40Z 2009 Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance / X. Xu, G. Yuan, W. Liu, Y. Zhang, W. Chen // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 102-105. — Бібліогр.: 19 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/135696 Aim: To study the expression of cathepsin L in nasopharyngeal carcinoma (NPC), and analyze its relationship with clinicopathologic factors. Methods: The expression of cathepsin L was determined immunohistochemically in NPC, adjacent normal nasopharyngeal tissues and metastatic cervical lymph nodes. The correlation between its protein expression and clinicopathologic parameters as well as with long term follow-up data in NPC was analyzed. Results: The protein of cathepsin L was overexpressed in 47% primary tumor tissues, and in 89% metastatic cervical lymph node samples. Overexpression of cathepsin L was found to correlate with lymph node metastasis (P = 0.04) and distant metastasis (P = 0.01), and marginally with clinical stage and T classification, but not with patient age, gender and histological classification of tumor. Patients with overexpression of cathepsin L in tumor tissue had worse 5-year survival than those without such expression pattern (P= 0.033). Multivariate survival analysis showed that cathepsin L protein expression level had a marginal significant correlation with prognosis of NPC. Conclusion: Cathepsin L is a potential biomarker for prognosis of NPC and contributes to NPC metastasis. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance |
| spellingShingle |
Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance Xu, X. Yuan, G. Liu, W. Zhang, Y. Chen, W. Original contributions |
| title_short |
Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance |
| title_full |
Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance |
| title_fullStr |
Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance |
| title_full_unstemmed |
Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance |
| title_sort |
expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance |
| author |
Xu, X. Yuan, G. Liu, W. Zhang, Y. Chen, W. |
| author_facet |
Xu, X. Yuan, G. Liu, W. Zhang, Y. Chen, W. |
| topic |
Original contributions |
| topic_facet |
Original contributions |
| publishDate |
2009 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Aim: To study the expression of cathepsin L in nasopharyngeal carcinoma (NPC), and analyze its relationship with clinicopathologic factors.
Methods: The expression of cathepsin L was determined immunohistochemically in NPC, adjacent normal nasopharyngeal tissues and metastatic
cervical lymph nodes. The correlation between its protein expression and clinicopathologic parameters as well as with long term follow-up data
in NPC was analyzed. Results: The protein of cathepsin L was overexpressed in 47% primary tumor tissues, and in 89% metastatic cervical
lymph node samples. Overexpression of cathepsin L was found to correlate with lymph node metastasis (P = 0.04) and distant metastasis
(P = 0.01), and marginally with clinical stage and T classification, but not with patient age, gender and histological classification of tumor.
Patients with overexpression of cathepsin L in tumor tissue had worse 5-year survival than those without such expression pattern (P= 0.033).
Multivariate survival analysis showed that cathepsin L protein expression level had a marginal significant correlation with prognosis of NPC.
Conclusion: Cathepsin L is a potential biomarker for prognosis of NPC and contributes to NPC metastasis.
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/135696 |
| citation_txt |
Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance / X. Xu, G. Yuan, W. Liu, Y. Zhang, W. Chen // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 102-105. — Бібліогр.: 19 назв. — англ. |
| work_keys_str_mv |
AT xux expressionofcathepsinlinnasopharyngealcarcinomaanditsclinicalsignificance AT yuang expressionofcathepsinlinnasopharyngealcarcinomaanditsclinicalsignificance AT liuw expressionofcathepsinlinnasopharyngealcarcinomaanditsclinicalsignificance AT zhangy expressionofcathepsinlinnasopharyngealcarcinomaanditsclinicalsignificance AT chenw expressionofcathepsinlinnasopharyngealcarcinomaanditsclinicalsignificance |
| first_indexed |
2025-12-07T19:52:07Z |
| last_indexed |
2025-12-07T19:52:07Z |
| _version_ |
1850880428620120064 |