Nuclear receptors and their role in epstein — barr virus induced b cell transformation

• Published in: Experimental Oncology
• Date: 2009
• Main Authors: Yenamandra, S.P., Klein, G., Kashuba, E.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/135697
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Nuclear receptors and their role in epstein — barr virus induced b cell transformation / S.P. Yenamandra, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 67-73. — Бібліогр.: 81 назв. — англ.

Epstein — Barr virus (EBV) is a lymphotropic virus that infects more than 90% of the human population, and targets B cells for
 infection. Infection of human B cells leads to the malignant transformation and eventual immortalization. In latency III infection
 six EBV-encoded nuclear antigens (EBNAs) and three latent membrane proteins (LMPs) are expressed in the transformed cells
 that can grow as a lymphoblastoid cell lines in vitro. These proteins hijack the normal B cell growth pathways by activating the
 constitutive growth promotion and external survival signals. We have determined a set of the nuclear receptors that are up- (and
 down-) regulated in the latency III infected cells at the mRNA level. In the present paper we discussed the possible role of these
 receptors in B cell transformation upon EBV infection based on the literature data.