Nuclear receptors and their role in epstein — barr virus induced b cell transformation
Epstein — Barr virus (EBV) is a lymphotropic virus that infects more than 90% of the human population, and targets B cells for infection. Infection of human B cells leads to the malignant transformation and eventual immortalization. In latency III infection six EBV-encoded nuclear antigens (EBNAs)...
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| Published in: | Experimental Oncology |
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| Date: | 2009 |
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/135697 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Nuclear receptors and their role in epstein — barr virus induced b cell transformation / S.P. Yenamandra, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 67-73. — Бібліогр.: 81 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
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Yenamandra, S.P. Klein, G. Kashuba, E. 2018-06-15T14:00:35Z 2018-06-15T14:00:35Z 2009 Nuclear receptors and their role in epstein — barr virus induced b cell transformation / S.P. Yenamandra, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 67-73. — Бібліогр.: 81 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/135697 Epstein — Barr virus (EBV) is a lymphotropic virus that infects more than 90% of the human population, and targets B cells for infection. Infection of human B cells leads to the malignant transformation and eventual immortalization. In latency III infection six EBV-encoded nuclear antigens (EBNAs) and three latent membrane proteins (LMPs) are expressed in the transformed cells that can grow as a lymphoblastoid cell lines in vitro. These proteins hijack the normal B cell growth pathways by activating the constitutive growth promotion and external survival signals. We have determined a set of the nuclear receptors that are up- (and down-) regulated in the latency III infected cells at the mRNA level. In the present paper we discussed the possible role of these receptors in B cell transformation upon EBV infection based on the literature data. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews Nuclear receptors and their role in epstein — barr virus induced b cell transformation Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| spellingShingle |
Nuclear receptors and their role in epstein — barr virus induced b cell transformation Yenamandra, S.P. Klein, G. Kashuba, E. Reviews |
| title_short |
Nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| title_full |
Nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| title_fullStr |
Nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| title_full_unstemmed |
Nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| title_sort |
nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| author |
Yenamandra, S.P. Klein, G. Kashuba, E. |
| author_facet |
Yenamandra, S.P. Klein, G. Kashuba, E. |
| topic |
Reviews |
| topic_facet |
Reviews |
| publishDate |
2009 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Epstein — Barr virus (EBV) is a lymphotropic virus that infects more than 90% of the human population, and targets B cells for
infection. Infection of human B cells leads to the malignant transformation and eventual immortalization. In latency III infection
six EBV-encoded nuclear antigens (EBNAs) and three latent membrane proteins (LMPs) are expressed in the transformed cells
that can grow as a lymphoblastoid cell lines in vitro. These proteins hijack the normal B cell growth pathways by activating the
constitutive growth promotion and external survival signals. We have determined a set of the nuclear receptors that are up- (and
down-) regulated in the latency III infected cells at the mRNA level. In the present paper we discussed the possible role of these
receptors in B cell transformation upon EBV infection based on the literature data.
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/135697 |
| citation_txt |
Nuclear receptors and their role in epstein — barr virus induced b cell transformation / S.P. Yenamandra, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 67-73. — Бібліогр.: 81 назв. — англ. |
| work_keys_str_mv |
AT yenamandrasp nuclearreceptorsandtheirroleinepsteinbarrvirusinducedbcelltransformation AT kleing nuclearreceptorsandtheirroleinepsteinbarrvirusinducedbcelltransformation AT kashubae nuclearreceptorsandtheirroleinepsteinbarrvirusinducedbcelltransformation |
| first_indexed |
2025-12-07T18:45:18Z |
| last_indexed |
2025-12-07T18:45:18Z |
| _version_ |
1850876224760446976 |