Nuclear receptors and their role in epstein — barr virus induced b cell transformation
Epstein — Barr virus (EBV) is a lymphotropic virus that infects more than 90% of the human population, and targets B cells for
 infection. Infection of human B cells leads to the malignant transformation and eventual immortalization. In latency III infection
 six EBV-encoded nuclear...
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| Опубліковано в: : | Experimental Oncology |
|---|---|
| Дата: | 2009 |
| Автори: | , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/135697 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Nuclear receptors and their role in epstein — barr virus induced b cell transformation / S.P. Yenamandra, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 67-73. — Бібліогр.: 81 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862724107711283200 |
|---|---|
| author | Yenamandra, S.P. Klein, G. Kashuba, E. |
| author_facet | Yenamandra, S.P. Klein, G. Kashuba, E. |
| citation_txt | Nuclear receptors and their role in epstein — barr virus induced b cell transformation / S.P. Yenamandra, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 67-73. — Бібліогр.: 81 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Epstein — Barr virus (EBV) is a lymphotropic virus that infects more than 90% of the human population, and targets B cells for
infection. Infection of human B cells leads to the malignant transformation and eventual immortalization. In latency III infection
six EBV-encoded nuclear antigens (EBNAs) and three latent membrane proteins (LMPs) are expressed in the transformed cells
that can grow as a lymphoblastoid cell lines in vitro. These proteins hijack the normal B cell growth pathways by activating the
constitutive growth promotion and external survival signals. We have determined a set of the nuclear receptors that are up- (and
down-) regulated in the latency III infected cells at the mRNA level. In the present paper we discussed the possible role of these
receptors in B cell transformation upon EBV infection based on the literature data.
|
| first_indexed | 2025-12-07T18:45:18Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-135697 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T18:45:18Z |
| publishDate | 2009 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Yenamandra, S.P. Klein, G. Kashuba, E. 2018-06-15T14:00:35Z 2018-06-15T14:00:35Z 2009 Nuclear receptors and their role in epstein — barr virus induced b cell transformation / S.P. Yenamandra, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 67-73. — Бібліогр.: 81 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/135697 Epstein — Barr virus (EBV) is a lymphotropic virus that infects more than 90% of the human population, and targets B cells for
 infection. Infection of human B cells leads to the malignant transformation and eventual immortalization. In latency III infection
 six EBV-encoded nuclear antigens (EBNAs) and three latent membrane proteins (LMPs) are expressed in the transformed cells
 that can grow as a lymphoblastoid cell lines in vitro. These proteins hijack the normal B cell growth pathways by activating the
 constitutive growth promotion and external survival signals. We have determined a set of the nuclear receptors that are up- (and
 down-) regulated in the latency III infected cells at the mRNA level. In the present paper we discussed the possible role of these
 receptors in B cell transformation upon EBV infection based on the literature data. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews Nuclear receptors and their role in epstein — barr virus induced b cell transformation Article published earlier |
| spellingShingle | Nuclear receptors and their role in epstein — barr virus induced b cell transformation Yenamandra, S.P. Klein, G. Kashuba, E. Reviews |
| title | Nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| title_full | Nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| title_fullStr | Nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| title_full_unstemmed | Nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| title_short | Nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| title_sort | nuclear receptors and their role in epstein — barr virus induced b cell transformation |
| topic | Reviews |
| topic_facet | Reviews |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/135697 |
| work_keys_str_mv | AT yenamandrasp nuclearreceptorsandtheirroleinepsteinbarrvirusinducedbcelltransformation AT kleing nuclearreceptorsandtheirroleinepsteinbarrvirusinducedbcelltransformation AT kashubae nuclearreceptorsandtheirroleinepsteinbarrvirusinducedbcelltransformation |