Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation
Background: Infection of human B cells with Epstein—Barr virus (EBV) induces metabolic activation, morphological transformation, cell
 proliferation and eventual immortalization. Aim: To identify the nuclear receptors, which are the cellular interaction partners of EBNAs,
 that will...
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| Published in: | Experimental Oncology |
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| Date: | 2009 |
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/135700 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation / S.P. Yenamandra, A. Lundin1, V. Arulampalam, M. Yurchenko, S. Pettersson, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 92–96. — Бібліогр.: 23 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862532386175057920 |
|---|---|
| author | Yenamandra, S.P. Lundin, A. Arulampalam, V. Yurchenko, M. Pettersson, S. Klein, G. Kashuba, E. |
| author_facet | Yenamandra, S.P. Lundin, A. Arulampalam, V. Yurchenko, M. Pettersson, S. Klein, G. Kashuba, E. |
| citation_txt | Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation / S.P. Yenamandra, A. Lundin1, V. Arulampalam, M. Yurchenko, S. Pettersson, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 92–96. — Бібліогр.: 23 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Background: Infection of human B cells with Epstein—Barr virus (EBV) induces metabolic activation, morphological transformation, cell
proliferation and eventual immortalization. Aim: To identify the nuclear receptors, which are the cellular interaction partners of EBNAs,
that will help to elucidate the mechanism of B cell transformation. Methods: We have compared the nuclear receptor profile in the naïve
and EBV-transformed B-lymphocytes, using TaqMan LDA microfluidic card technology. Results: Out of 48 nuclear receptor, 17 showed
differential expression at the mRNA level. The expression of 5 genes was elevated in EBV-transformed cells, whereas 12 genes were downregulated
in lymphoblastoid cells (LCLs). 7 genes were studied at the protein level; 2 genes were up regulated (Nr2F2 and RARA) and
4 genes were down regulated (ERB, NUR77, PPARG, and VDR) in LCLs. Conclusion: The nuclear receptor profiling on EBV infected
B cells showed alterations of nuclear receptors expression at both mRNA and protein levels compared with non infected peripheral blood
cells. Further analysis on a possible role of each nuclear receptor in EBV induced cell transformation should be performed.
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| first_indexed | 2025-11-24T04:31:31Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-135700 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-24T04:31:31Z |
| publishDate | 2009 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Yenamandra, S.P. Lundin, A. Arulampalam, V. Yurchenko, M. Pettersson, S. Klein, G. Kashuba, E. 2018-06-15T14:02:50Z 2018-06-15T14:02:50Z 2009 Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation / S.P. Yenamandra, A. Lundin1, V. Arulampalam, M. Yurchenko, S. Pettersson, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 92–96. — Бібліогр.: 23 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/135700 Background: Infection of human B cells with Epstein—Barr virus (EBV) induces metabolic activation, morphological transformation, cell
 proliferation and eventual immortalization. Aim: To identify the nuclear receptors, which are the cellular interaction partners of EBNAs,
 that will help to elucidate the mechanism of B cell transformation. Methods: We have compared the nuclear receptor profile in the naïve
 and EBV-transformed B-lymphocytes, using TaqMan LDA microfluidic card technology. Results: Out of 48 nuclear receptor, 17 showed
 differential expression at the mRNA level. The expression of 5 genes was elevated in EBV-transformed cells, whereas 12 genes were downregulated
 in lymphoblastoid cells (LCLs). 7 genes were studied at the protein level; 2 genes were up regulated (Nr2F2 and RARA) and
 4 genes were down regulated (ERB, NUR77, PPARG, and VDR) in LCLs. Conclusion: The nuclear receptor profiling on EBV infected
 B cells showed alterations of nuclear receptors expression at both mRNA and protein levels compared with non infected peripheral blood
 cells. Further analysis on a possible role of each nuclear receptor in EBV induced cell transformation should be performed. Swedish Cancer Society, a matching grant from the
 Concern Foundation (Los Angeles), the Cancer Research
 Institute (New York), Swedish Institute, and Swedish Foundation
 for Strategic Research supported this work. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation Article published earlier |
| spellingShingle | Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation Yenamandra, S.P. Lundin, A. Arulampalam, V. Yurchenko, M. Pettersson, S. Klein, G. Kashuba, E. Original contributions |
| title | Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation |
| title_full | Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation |
| title_fullStr | Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation |
| title_full_unstemmed | Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation |
| title_short | Expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation |
| title_sort | expression profile of nuclear receptors upon epstein — barr virus induced b cell transformation |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/135700 |
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