Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate

• Veröffentlicht in: Experimental Oncology
• Datum: 2009
• Hauptverfasser: Pai, R.B., Lalitha, R.M., Pai, S.B., Kumaraswamy, S.V., Lalitha, N., Bhargava, M.K.
• Format: Artikel
• Sprache: English
• Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
• Schlagworte: Short communications
• Online Zugang: https://nasplib.isofts.kiev.ua/handle/123456789/135717
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Zitieren: Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate / R.B. Pai, R.M. Lalitha, S.B. Pai, S.V. Kumaraswamy, N. Lalitha, M.K. Bhargava // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 118–120. — Бібліогр.: 14 назв. — англ.

Aim: The present study was directed on the assessment of the response of treatment-naive oral cancer cells to methotrexate (MTX) in vitro and clinical response to MTX therapy. Methods: A pilot study of in vitro evaluation of MTX response of oral cancer cells from 10 patients was conducted using a cell viability assay to determine the sensitivity/resistance to MTX. Quantitative in vitro data were correlated to the clinical outcome to MTX therapy. Results: A positive correlation was observed between the effect of MTX on tumor cells in vitro and clinical response for 7 out of 10 patients. Conclusions: Observations from the proof-of-principle pilot study suggests that oral cancer cells have intrinsically variable response toMTX. Confirmation ofthese findings with a larger cohort of patients could aid in the development of individualized therapies for this class of malignancy.