Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate
Aim: The present study was directed on the assessment of the response of treatment-naive oral cancer cells to methotrexate (MTX)
 in vitro and clinical response to MTX therapy. Methods: A pilot study of in vitro evaluation of MTX response of oral cancer cells
 from 10 patients was co...
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2009 |
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | Englisch |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Online Zugang: | https://nasplib.isofts.kiev.ua/handle/123456789/135717 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate / R.B. Pai, R.M. Lalitha, S.B. Pai, S.V. Kumaraswamy, N. Lalitha, M.K. Bhargava // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 118–120. — Бібліогр.: 14 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862664990898520064 |
|---|---|
| author | Pai, R.B. Lalitha, R.M. Pai, S.B. Kumaraswamy, S.V. Lalitha, N. Bhargava, M.K. |
| author_facet | Pai, R.B. Lalitha, R.M. Pai, S.B. Kumaraswamy, S.V. Lalitha, N. Bhargava, M.K. |
| citation_txt | Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate / R.B. Pai, R.M. Lalitha, S.B. Pai, S.V. Kumaraswamy, N. Lalitha, M.K. Bhargava // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 118–120. — Бібліогр.: 14 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: The present study was directed on the assessment of the response of treatment-naive oral cancer cells to methotrexate (MTX)
in vitro and clinical response to MTX therapy. Methods: A pilot study of in vitro evaluation of MTX response of oral cancer cells
from 10 patients was conducted using a cell viability assay to determine the sensitivity/resistance to MTX. Quantitative in vitro data
were correlated to the clinical outcome to MTX therapy. Results: A positive correlation was observed between the effect of MTX
on tumor cells in vitro and clinical response for 7 out of 10 patients. Conclusions: Observations from the proof-of-principle pilot
study suggests that oral cancer cells have intrinsically variable response toMTX. Confirmation ofthese findings with a larger cohort
of patients could aid in the development of individualized therapies for this class of malignancy.
|
| first_indexed | 2025-12-07T15:15:55Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-135717 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T15:15:55Z |
| publishDate | 2009 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Pai, R.B. Lalitha, R.M. Pai, S.B. Kumaraswamy, S.V. Lalitha, N. Bhargava, M.K. 2018-06-15T14:18:34Z 2018-06-15T14:18:34Z 2009 Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate / R.B. Pai, R.M. Lalitha, S.B. Pai, S.V. Kumaraswamy, N. Lalitha, M.K. Bhargava // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 118–120. — Бібліогр.: 14 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/135717 Aim: The present study was directed on the assessment of the response of treatment-naive oral cancer cells to methotrexate (MTX)
 in vitro and clinical response to MTX therapy. Methods: A pilot study of in vitro evaluation of MTX response of oral cancer cells
 from 10 patients was conducted using a cell viability assay to determine the sensitivity/resistance to MTX. Quantitative in vitro data
 were correlated to the clinical outcome to MTX therapy. Results: A positive correlation was observed between the effect of MTX
 on tumor cells in vitro and clinical response for 7 out of 10 patients. Conclusions: Observations from the proof-of-principle pilot
 study suggests that oral cancer cells have intrinsically variable response toMTX. Confirmation ofthese findings with a larger cohort
 of patients could aid in the development of individualized therapies for this class of malignancy. This study was supported by the Indian Council
 of Medical Research, New Delhi, India. We thank
 Rohith Pai for critical reading of the manuscript and
 valuable suggestions. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Short communications Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate Article published earlier |
| spellingShingle | Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate Pai, R.B. Lalitha, R.M. Pai, S.B. Kumaraswamy, S.V. Lalitha, N. Bhargava, M.K. Short communications |
| title | Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate |
| title_full | Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate |
| title_fullStr | Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate |
| title_full_unstemmed | Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate |
| title_short | Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate |
| title_sort | analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate |
| topic | Short communications |
| topic_facet | Short communications |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/135717 |
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