Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients — impact of cryopreservation with dimethylsulfoxide

Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients — impact of cryopreservation with dimethylsulfoxide

Aim: Dimethylsulfoxide (DMSO) is the most frequently used agent for hematopoietic cell (HC) graft cryopreservation. This study aimed to monitor blood pressure and heart rate (HR) during HC graft infusion and assess the impact of cryopreservation with DMSO. Methods: 153 HC graft infusions in 153 co...

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Бібліографічні деталі
Опубліковано в: :Experimental Oncology
Дата:2009
Автори: Horacek, J.M., Jebavy, L., Jakl, M., Zak, P., Mericka, P., Maly, J.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
Теми:
Short communications
Онлайн доступ:https://nasplib.isofts.kiev.ua/handle/123456789/135722
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients — impact of cryopreservation with dimethylsulfoxide / J.M. Horacek, L. Jebavy, M. Jakl, P. Zak, P. Mericka, J. Maly // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 121–122. — Бібліогр.: 15 назв. — англ.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-135722
record_format dspace
spelling Horacek, J.M.
Jebavy, L.
Jakl, M.
Zak, P.
Mericka, P.
Maly, J.
2018-06-15T14:20:01Z
2018-06-15T14:20:01Z
2009
Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients — impact of cryopreservation with dimethylsulfoxide / J.M. Horacek, L. Jebavy, M. Jakl, P. Zak, P. Mericka, J. Maly // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 121–122. — Бібліогр.: 15 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/135722
Aim: Dimethylsulfoxide (DMSO) is the most frequently used agent for hematopoietic cell (HC) graft cryopreservation. This study aimed to monitor blood pressure and heart rate (HR) during HC graft infusion and assess the impact of cryopreservation with DMSO. Methods: 153 HC graft infusions in 153 consecutive hematological patients (mean age 49.1 ± 12.6 years; 80 males) were evaluated. Cryopreservation with DMSO was used in 133 grafts (DMSO group). Twenty grafts were infused directly without cryopreservation (control group). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and HR were measured immediately before and after HC graft infusion. Results: SBP and DBP increased significantly after graft infusions cryopreserved with DMSO (p < 0.0001 for SBP; p < 0.01 for DBP). Increases (> 10 mmHg) in SBP were seen in 42 (31.6%) patients; in DBP in 31 (23.3%) patients. Changes in HR were non-significant in DMSO group. Increases in BP and HR correlated with increasing DMSO dose (p < 0.01; p < 0.05, respectively). Changes in SBP, DBP and HR were non-significant in control group. Conclusion: HC graft infusions cryopreserved with DMSO could cause statistically significant increases in SBP and DBP, without changes in HR. These changes were mostly transient and asymptomatic, not requiring therapeutic intervention. However, they might cause complications, especially in patients with preexisting cardiovascular disease, who should be monitored closely during HC transplantation.
The work was supported by research projects MO 0FVZ 0000503 (Czech Ministry of Defence) and MZO 00179906 (Czech Ministry of Health).
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Short communications
Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients — impact of cryopreservation with dimethylsulfoxide
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients — impact of cryopreservation with dimethylsulfoxide
spellingShingle Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients — impact of cryopreservation with dimethylsulfoxide
Horacek, J.M.
Jebavy, L.
Jakl, M.
Zak, P.
Mericka, P.
Maly, J.
Short communications
title_short Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients — impact of cryopreservation with dimethylsulfoxide
title_full Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients — impact of cryopreservation with dimethylsulfoxide
title_fullStr Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients — impact of cryopreservation with dimethylsulfoxide
title_full_unstemmed Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients — impact of cryopreservation with dimethylsulfoxide
title_sort cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients — impact of cryopreservation with dimethylsulfoxide
author Horacek, J.M.
Jebavy, L.
Jakl, M.
Zak, P.
Mericka, P.
Maly, J.
author_facet Horacek, J.M.
Jebavy, L.
Jakl, M.
Zak, P.
Mericka, P.
Maly, J.
topic Short communications
topic_facet Short communications
publishDate 2009
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: Dimethylsulfoxide (DMSO) is the most frequently used agent for hematopoietic cell (HC) graft cryopreservation. This study aimed to monitor blood pressure and heart rate (HR) during HC graft infusion and assess the impact of cryopreservation with DMSO. Methods: 153 HC graft infusions in 153 consecutive hematological patients (mean age 49.1 ± 12.6 years; 80 males) were evaluated. Cryopreservation with DMSO was used in 133 grafts (DMSO group). Twenty grafts were infused directly without cryopreservation (control group). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and HR were measured immediately before and after HC graft infusion. Results: SBP and DBP increased significantly after graft infusions cryopreserved with DMSO (p < 0.0001 for SBP; p < 0.01 for DBP). Increases (> 10 mmHg) in SBP were seen in 42 (31.6%) patients; in DBP in 31 (23.3%) patients. Changes in HR were non-significant in DMSO group. Increases in BP and HR correlated with increasing DMSO dose (p < 0.01; p < 0.05, respectively). Changes in SBP, DBP and HR were non-significant in control group. Conclusion: HC graft infusions cryopreserved with DMSO could cause statistically significant increases in SBP and DBP, without changes in HR. These changes were mostly transient and asymptomatic, not requiring therapeutic intervention. However, they might cause complications, especially in patients with preexisting cardiovascular disease, who should be monitored closely during HC transplantation.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/135722
citation_txt Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients — impact of cryopreservation with dimethylsulfoxide / J.M. Horacek, L. Jebavy, M. Jakl, P. Zak, P. Mericka, J. Maly // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 121–122. — Бібліогр.: 15 назв. — англ.
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first_indexed 2025-12-07T20:39:27Z
last_indexed 2025-12-07T20:39:27Z
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