Expression of drug resistance proteins in triple-receptor-negative tumors as the basis of individualized therapy of the breast cancer patients
Aim: To evaluate the efficacy ofthe application of various chemotherapy schemes based on the immunohistochemical study of expression
 patterns of proteins associated with the drug resistance P-glycoprotein (P-gp), glutathione-S-transferase (GST), metallothioneins
 (МТ) of breast canc...
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| Published in: | Experimental Oncology |
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| Date: | 2009 |
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/135725 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Expression of drug resistance proteins in triple-receptor-negative tumors as the basis of individualized therapy of the breast cancer patients / V.F. Chekhun, V.E. Zhylchuk, N.Yu. Lukyanova, A.L. Vorontsova, Yu.I. Kudryavets // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 123–124. — назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862751364551016448 |
|---|---|
| author | Chekhun, V.F. Zhylchuk, V.E. Lukyanova, N.Yu. Vorontsova, A.L. Kudryavets, Yu.I. |
| author_facet | Chekhun, V.F. Zhylchuk, V.E. Lukyanova, N.Yu. Vorontsova, A.L. Kudryavets, Yu.I. |
| citation_txt | Expression of drug resistance proteins in triple-receptor-negative tumors as the basis of individualized therapy of the breast cancer patients / V.F. Chekhun, V.E. Zhylchuk, N.Yu. Lukyanova, A.L. Vorontsova, Yu.I. Kudryavets // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 123–124. — назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: To evaluate the efficacy ofthe application of various chemotherapy schemes based on the immunohistochemical study of expression
patterns of proteins associated with the drug resistance P-glycoprotein (P-gp), glutathione-S-transferase (GST), metallothioneins
(МТ) of breast cancer (BC) patients with the triple-receptor-negative (RE–, RP–, HER-2/neu–) cancer. Methods and Results: P-gp,
GST and МТ expression in BC-biopsy samples from 60 BC patients was evaluated by immunohistochemical analysis. The results
of the clinical observations showed that 3-years relapse-free survival rate of the patients of with P-gp, GST and МТ-positive tumors
treated with taxoter + adriablastin / taxoter + cyclophosphamide (ТА/ТС), gemcitabine + carboplatin, or TC + bevacizumab was
61.5%, 78.6% and 81.2% respectively, vs 41.2% in the control group with P-gp, GST and МТ-negative tumors treated with adriablastin
+ cyclophosphamide (p < 0.05), while overall survival rates were 84.4%, 92.6% and 93.8% respectively vs 70.6% in the control
group (p < 0.05). Conclusion: The study points on the possibility to elevate the efficiency of polychemotherapy by its individualization
based on the expression patterns of Р-gp, GST and MT on tumor cells of the patients with the triple-receptor-negative BC.
|
| first_indexed | 2025-12-07T21:11:17Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-135725 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T21:11:17Z |
| publishDate | 2009 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Chekhun, V.F. Zhylchuk, V.E. Lukyanova, N.Yu. Vorontsova, A.L. Kudryavets, Yu.I. 2018-06-15T14:21:07Z 2018-06-15T14:21:07Z 2009 Expression of drug resistance proteins in triple-receptor-negative tumors as the basis of individualized therapy of the breast cancer patients / V.F. Chekhun, V.E. Zhylchuk, N.Yu. Lukyanova, A.L. Vorontsova, Yu.I. Kudryavets // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 123–124. — назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/135725 Aim: To evaluate the efficacy ofthe application of various chemotherapy schemes based on the immunohistochemical study of expression
 patterns of proteins associated with the drug resistance P-glycoprotein (P-gp), glutathione-S-transferase (GST), metallothioneins
 (МТ) of breast cancer (BC) patients with the triple-receptor-negative (RE–, RP–, HER-2/neu–) cancer. Methods and Results: P-gp,
 GST and МТ expression in BC-biopsy samples from 60 BC patients was evaluated by immunohistochemical analysis. The results
 of the clinical observations showed that 3-years relapse-free survival rate of the patients of with P-gp, GST and МТ-positive tumors
 treated with taxoter + adriablastin / taxoter + cyclophosphamide (ТА/ТС), gemcitabine + carboplatin, or TC + bevacizumab was
 61.5%, 78.6% and 81.2% respectively, vs 41.2% in the control group with P-gp, GST and МТ-negative tumors treated with adriablastin
 + cyclophosphamide (p < 0.05), while overall survival rates were 84.4%, 92.6% and 93.8% respectively vs 70.6% in the control
 group (p < 0.05). Conclusion: The study points on the possibility to elevate the efficiency of polychemotherapy by its individualization
 based on the expression patterns of Р-gp, GST and MT on tumor cells of the patients with the triple-receptor-negative BC. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Short communications Expression of drug resistance proteins in triple-receptor-negative tumors as the basis of individualized therapy of the breast cancer patients Article published earlier |
| spellingShingle | Expression of drug resistance proteins in triple-receptor-negative tumors as the basis of individualized therapy of the breast cancer patients Chekhun, V.F. Zhylchuk, V.E. Lukyanova, N.Yu. Vorontsova, A.L. Kudryavets, Yu.I. Short communications |
| title | Expression of drug resistance proteins in triple-receptor-negative tumors as the basis of individualized therapy of the breast cancer patients |
| title_full | Expression of drug resistance proteins in triple-receptor-negative tumors as the basis of individualized therapy of the breast cancer patients |
| title_fullStr | Expression of drug resistance proteins in triple-receptor-negative tumors as the basis of individualized therapy of the breast cancer patients |
| title_full_unstemmed | Expression of drug resistance proteins in triple-receptor-negative tumors as the basis of individualized therapy of the breast cancer patients |
| title_short | Expression of drug resistance proteins in triple-receptor-negative tumors as the basis of individualized therapy of the breast cancer patients |
| title_sort | expression of drug resistance proteins in triple-receptor-negative tumors as the basis of individualized therapy of the breast cancer patients |
| topic | Short communications |
| topic_facet | Short communications |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/135725 |
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