Ribonucleases. possible new approach in cancer therapy
In the review, the use of the ribonucleases for cancer therapy is discussed. Using of epigenetic mechanisms of regulation — blocking protein synthesis without affecting the DNA structure — is a promising direction in the therapy. The ribonucleases isolated from different sources, despite of simila...
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| Published in: | Experimental Oncology |
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| Date: | 2016 |
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| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2016
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| Subjects: | |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/136133 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Ribonucleases. possible new approach in cancer therapy / V.O. Shlyakhovenko // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 2–8. — Бібліогр.: 47 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | In the review, the use of the ribonucleases for cancer therapy is discussed. Using of epigenetic mechanisms of regulation — blocking
protein synthesis without affecting the DNA structure — is a promising direction in the therapy. The ribonucleases isolated from different
sources, despite of similar mechanism of enzymatic reactions, have different biological effects. The use of enzymes isolated from new
sources, particularly from plants and fungi, shows promising results. In this article we discuss the new approach for the use of enzymes
resistant to inhibitors and ribozymes, that is aimed at the destruction of the oncogene specific mRNA and the induction of apoptosis.
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| ISSN: | 1812-9269 |