HIF-1 — a big chapter in the cancer tale

• Опубліковано в: : Experimental Oncology
• Дата: 2016
• Автор: Ajduković, J.
• Формат: Стаття
• Мова: Англійська
• Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2016
• Теми: Minireview
• Онлайн доступ: https://nasplib.isofts.kiev.ua/handle/123456789/136134
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: HIF-1 — a big chapter in the cancer tale / J. Ajduković // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 9-12. — Бібліогр.: 37 назв. — англ.

Approximately 1.0–1.5% of the genome is transcriptionally regulated by hypoxia, and hypoxia-inducible factor (HIF)-1α is the
 transcription factor modulating many of these genes. Cancer cells are able to survive hypoxic environments and hypoxia itself can
 activate adaptive cellular responses that contribute to tumor progression. Many HIF-1α-mediated biological effects are beneficial
 for tumor progression, including metabolic shift toward glycolysis, inhibition of fatty acid β-oxidation, production of cellular reactive
 oxygen species and altering expression of tumor suppressor genes. HIF-1 promotes selective mitochondrial autophagy, resis- and altering expression of tumor suppressor genes. HIF-1 promotes selective mitochondrial autophagy, resistance
 to T cell mediated lysis of cancer cells, induction of pluripotent cancer stem cells, epithelial-mesenchymal and epithelialmesenchymal-endothelial
 transitions beneficial for tumor growth and progression, loss of E-cadherin. HIF-1 also induces production
 of signal molecules and cytokines by carcinoma-associated fibroblasts and upregulation of certain microRNAs important for
 cancer progression. This minireview focuses on the HIF-1 promoting role in tumor initiation and progression and HIF-1 targeting.
 HIF-1 pathway downregulation seems to be promising in future cancer treatment.