HIF-1 — a big chapter in the cancer tale
Approximately 1.0–1.5% of the genome is transcriptionally regulated by hypoxia, and hypoxia-inducible factor (HIF)-1α is the
 transcription factor modulating many of these genes. Cancer cells are able to survive hypoxic environments and hypoxia itself can
 activate adaptive cellular...
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| Published in: | Experimental Oncology |
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| Date: | 2016 |
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| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2016
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/136134 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | HIF-1 — a big chapter in the cancer tale / J. Ajduković // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 9-12. — Бібліогр.: 37 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862737356034932736 |
|---|---|
| author | Ajduković, J. |
| author_facet | Ajduković, J. |
| citation_txt | HIF-1 — a big chapter in the cancer tale / J. Ajduković // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 9-12. — Бібліогр.: 37 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Approximately 1.0–1.5% of the genome is transcriptionally regulated by hypoxia, and hypoxia-inducible factor (HIF)-1α is the
transcription factor modulating many of these genes. Cancer cells are able to survive hypoxic environments and hypoxia itself can
activate adaptive cellular responses that contribute to tumor progression. Many HIF-1α-mediated biological effects are beneficial
for tumor progression, including metabolic shift toward glycolysis, inhibition of fatty acid β-oxidation, production of cellular reactive
oxygen species and altering expression of tumor suppressor genes. HIF-1 promotes selective mitochondrial autophagy, resis- and altering expression of tumor suppressor genes. HIF-1 promotes selective mitochondrial autophagy, resistance
to T cell mediated lysis of cancer cells, induction of pluripotent cancer stem cells, epithelial-mesenchymal and epithelialmesenchymal-endothelial
transitions beneficial for tumor growth and progression, loss of E-cadherin. HIF-1 also induces production
of signal molecules and cytokines by carcinoma-associated fibroblasts and upregulation of certain microRNAs important for
cancer progression. This minireview focuses on the HIF-1 promoting role in tumor initiation and progression and HIF-1 targeting.
HIF-1 pathway downregulation seems to be promising in future cancer treatment.
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| first_indexed | 2025-12-07T19:59:03Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-136134 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T19:59:03Z |
| publishDate | 2016 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Ajduković, J. 2018-06-15T21:38:49Z 2018-06-15T21:38:49Z 2016 HIF-1 — a big chapter in the cancer tale / J. Ajduković // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 9-12. — Бібліогр.: 37 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/136134 Approximately 1.0–1.5% of the genome is transcriptionally regulated by hypoxia, and hypoxia-inducible factor (HIF)-1α is the
 transcription factor modulating many of these genes. Cancer cells are able to survive hypoxic environments and hypoxia itself can
 activate adaptive cellular responses that contribute to tumor progression. Many HIF-1α-mediated biological effects are beneficial
 for tumor progression, including metabolic shift toward glycolysis, inhibition of fatty acid β-oxidation, production of cellular reactive
 oxygen species and altering expression of tumor suppressor genes. HIF-1 promotes selective mitochondrial autophagy, resis- and altering expression of tumor suppressor genes. HIF-1 promotes selective mitochondrial autophagy, resistance
 to T cell mediated lysis of cancer cells, induction of pluripotent cancer stem cells, epithelial-mesenchymal and epithelialmesenchymal-endothelial
 transitions beneficial for tumor growth and progression, loss of E-cadherin. HIF-1 also induces production
 of signal molecules and cytokines by carcinoma-associated fibroblasts and upregulation of certain microRNAs important for
 cancer progression. This minireview focuses on the HIF-1 promoting role in tumor initiation and progression and HIF-1 targeting.
 HIF-1 pathway downregulation seems to be promising in future cancer treatment. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Minireview HIF-1 — a big chapter in the cancer tale Article published earlier |
| spellingShingle | HIF-1 — a big chapter in the cancer tale Ajduković, J. Minireview |
| title | HIF-1 — a big chapter in the cancer tale |
| title_full | HIF-1 — a big chapter in the cancer tale |
| title_fullStr | HIF-1 — a big chapter in the cancer tale |
| title_full_unstemmed | HIF-1 — a big chapter in the cancer tale |
| title_short | HIF-1 — a big chapter in the cancer tale |
| title_sort | hif-1 — a big chapter in the cancer tale |
| topic | Minireview |
| topic_facet | Minireview |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/136134 |
| work_keys_str_mv | AT ajdukovicj hif1abigchapterinthecancertale |