HIF-1 — a big chapter in the cancer tale

• Published in: Experimental Oncology
• Date: 2016
• Main Author: Ajduković, J.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2016
• Subjects: Minireview
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/136134
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: HIF-1 — a big chapter in the cancer tale / J. Ajduković // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 9-12. — Бібліогр.: 37 назв. — англ.

Approximately 1.0–1.5% of the genome is transcriptionally regulated by hypoxia, and hypoxia-inducible factor (HIF)-1α is the
 transcription factor modulating many of these genes. Cancer cells are able to survive hypoxic environments and hypoxia itself can
 activate adaptive cellular...