Adsorption of ceftriaxon by biogenic hydroxyapatite with magnetic additions

• Veröffentlicht in: Functional Materials
• Datum: 2017
• Hauptverfasser: Otychenko, O.M., Babutina, T.Ye., Kuda, O.A., Budylina, O.M., Protsenko, L.S., Koval, O.Yu., Uvarova, I.V.
• Format: Artikel
• Sprache: English
• Veröffentlicht: НТК «Інститут монокристалів» НАН України 2017
• Schlagworte: Characterization and properties
• Online Zugang: https://nasplib.isofts.kiev.ua/handle/123456789/136858
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Zitieren: Adsorption of ceftriaxon by biogenic hydroxyapatite with magnetic additions / O.M. Otychenko, T.Ye. Babutina, O.A. Kuda, O.M. Budylina, L.S. Protsenko, O.Yu. Koval, I.V. Uvarova // Functional Materials. — 2017. — Т. 24, № 4. — С. 577-583. — Бібліогр.: 30 назв. — англ.

The possibility of using nanoporous composite system based on biogenic hydroxyapatite (BHA), which alloyed by ferromagnetic additives due to using two methods of physicochemical mixing, as a carrier of drugs for orthopedics and traumatology was shown. It was found that the sample obtained by precipitation previously prepared iron oxalate on the surface of BHA microspheres has a greater adsorption activity than the sample obtained by including BHA directly in the process of obtaining iron oxalate (300 and 175 mg/g respectively). However, due to the difference in porosity, they are capable to hold a different amount of the injected antibiotic mass: 6 mass.% - for material obtained by physico-mechanical method and 10 mass.% - for the sample obtained by chemical method.