Cross-resistance to cytosine arabinoside in human acute myeloid leukemia cells selected for resistance to vincristine

• Published in: Experimental Oncology
• Date: 2006
• Main Authors: Gunduz, U., Baran, Y., Uralsup, A.U.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2006
• Subjects: Short communications
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/137564
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Cross-resistance to cytosine arabinoside in human acute myeloid leukemia cells selected for resistance to vincristine / U. Gunduz, Y. Baran, A.U. Uralsup // Experimental Oncology. — 2006. — Т. 28, № 2. — С. 163-165. — Бібліогр.: 16 назв. — англ.

Aim: The goals of the study were to reveal the involvement of P-glycoprotein (P-gp), the product of multidrug resistance 1 gene (MDR1) in cellular resistance to vincristine (VCR) and investigate cross-resistance against cytosine arabinoside (Ara-C) in HL60 and HL60/VCR cell lines. Methods: HL60 cell...