Sensitivity of human lymphocytes to genotoxic effect of N-methyl-N-nitrosourea: possible relation to gynecological cancers

• Date: 2006
• Main Authors: Tronov, V.A., Kramarenko, I.I., Kozlova, A.D., Dederer, L.J., Kedrova, A.G., Gorbacheva, L.B.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2006
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/137585
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Sensitivity of human lymphocytes to genotoxic effect of N-methyl-N-nitrosourea: possible relation to gynecological cancers / V.A. Tronov, I.I. Kramarenko, A.D. Kozlova, L.J. Dederer, A.G. Kedrova, L.B. Gorbacheva // Experimental Oncology. — 2006. — Т. 28, № 4. — С. 314-318. — Бібліогр.: 22 назв. — англ.

The aim of this work is to study responses of PHA-stimulated and resting lymphocytes to methylating agent N-methyl-N-nitrosourea (MNU) and to compare sensitivity to this agent of healthy donor lymphocytes and lymphocytes from patients with gynecological cancers. Methods: Cytotoxicity of MNU, apoptot...