The study of possibility to elevate antitumor activity and decrease of systemic toxic effects of cisplatin by its binding with deliganded albumin

• Date: 2006
• Main Authors: Sakhno, L.A., Sarnatskaya, V.V., Yushko, L.A., Melnikov, O.R., Momot, V.Ya., Korneeva, L.N., Svintsiskiy, V.S., Korotich, V.G., Nechitaylo, I.I., Nikolaev, V.G.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2006
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/137586
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: The study of possibility to elevate antitumor activity and decrease of systemic toxic effects of cisplatin by its binding with deliganded albumin / L.A. Sakhno, V.V. Sarnatskaya, L.A. Yushko, O.R. Melnikov, V.Ya. Momot, L.N. Korneeva, V.S. Svintsiskiy, V.G. Korotich, I.I. Nechitaylo, V.G. Nikolaev // Experimental Oncology. — 2006. — Т. 28, № 4. — С. 303-307. — Бібліогр.: 17 назв. — англ.

Aim: To evaluate antitumor and toxic action of cisplatin (CP) in non-bound form and in a complex with deliganded albumin. Methods: To study complex-formation between CP and albumin, differential scanning and isothermic flow microcalorimetry were used. For quantitive evaluation of albumin-bound CP, t...