Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development?
In childhood tumors, including retinoblastoma, osteosarcoma, and neuroblastoma, the RB-E2F1 pathway is inactivated, as a rule. These tumors arise from precursor cells that fail to undergo the terminal differentiation. Noteworthy, the RB1-encoded protein (RB) does not control the cell cycle in embryo...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2017 |
| Автори: | , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2017
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/137599 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? / E. Kashuba, M. Mushtaq // Experimental Oncology. — 2017 — Т. 39, № 1. — С. 12-16. — Бібліогр.: 21 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862575727148269568 |
|---|---|
| author | Kashuba, E. Mushtaq, M. |
| author_facet | Kashuba, E. Mushtaq, M. |
| citation_txt | Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? / E. Kashuba, M. Mushtaq // Experimental Oncology. — 2017 — Т. 39, № 1. — С. 12-16. — Бібліогр.: 21 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | In childhood tumors, including retinoblastoma, osteosarcoma, and neuroblastoma, the RB-E2F1 pathway is inactivated, as a rule. These tumors arise from precursor cells that fail to undergo the terminal differentiation. Noteworthy, the RB1-encoded protein (RB) does not control the cell cycle in embryonic stem cells. It has not been yet well understood how RB controls cell stemness and differentiation. The question arises why “inactive” RB is required for the survival and stemness of cells? Recently, we have found that overexpression of the RB-binding protein MRPS18-2 (S18-2) in primary fibroblasts leads to their immortalization, which is accompanied by the induction of embryonic stem cell markers and, eventually, malignant transformation. We suggest that cell stemness may be associated with high expression levels of both proteins, RB and S18-2. There must be a strict regulation of the expression levels of S18-2 and RB during embryogenesis. Disturbances in the expression of these proteins would lead to the abnormalities in development. We think that the S18-2 protein, together with the RB, plays a crucial role in the control on cell stemness and differentiation. We hope to uncover the new mechanisms of the cell fate determination. The S18-2 may serve as a new target for anticancer medicines, which will help to improve human health.
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| first_indexed | 2025-11-26T13:18:03Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-137599 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-26T13:18:03Z |
| publishDate | 2017 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Kashuba, E. Mushtaq, M. 2018-06-17T13:51:03Z 2018-06-17T13:51:03Z 2017 Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? / E. Kashuba, M. Mushtaq // Experimental Oncology. — 2017 — Т. 39, № 1. — С. 12-16. — Бібліогр.: 21 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/137599 In childhood tumors, including retinoblastoma, osteosarcoma, and neuroblastoma, the RB-E2F1 pathway is inactivated, as a rule. These tumors arise from precursor cells that fail to undergo the terminal differentiation. Noteworthy, the RB1-encoded protein (RB) does not control the cell cycle in embryonic stem cells. It has not been yet well understood how RB controls cell stemness and differentiation. The question arises why “inactive” RB is required for the survival and stemness of cells? Recently, we have found that overexpression of the RB-binding protein MRPS18-2 (S18-2) in primary fibroblasts leads to their immortalization, which is accompanied by the induction of embryonic stem cell markers and, eventually, malignant transformation. We suggest that cell stemness may be associated with high expression levels of both proteins, RB and S18-2. There must be a strict regulation of the expression levels of S18-2 and RB during embryogenesis. Disturbances in the expression of these proteins would lead to the abnormalities in development. We think that the S18-2 protein, together with the RB, plays a crucial role in the control on cell stemness and differentiation. We hope to uncover the new mechanisms of the cell fate determination. The S18-2 may serve as a new target for anticancer medicines, which will help to improve human health. We thank Professor George Klein for the fruitful discussions on the proposed hypothesis. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Point of view Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? Article published earlier |
| spellingShingle | Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? Kashuba, E. Mushtaq, M. Point of view |
| title | Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? |
| title_full | Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? |
| title_fullStr | Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? |
| title_full_unstemmed | Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? |
| title_short | Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? |
| title_sort | do mrps18-2 and rb proteins cooperate to control cell stemness and differentiation, preventing cancer development? |
| topic | Point of view |
| topic_facet | Point of view |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/137599 |
| work_keys_str_mv | AT kashubae domrps182andrbproteinscooperatetocontrolcellstemnessanddifferentiationpreventingcancerdevelopment AT mushtaqm domrps182andrbproteinscooperatetocontrolcellstemnessanddifferentiationpreventingcancerdevelopment |