Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development?

• Published in: Experimental Oncology
• Date: 2017
• Main Authors: Kashuba, E., Mushtaq, M.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2017
• Subjects: Point of view
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/137599
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? / E. Kashuba, M. Mushtaq // Experimental Oncology. — 2017 — Т. 39, № 1. — С. 12-16. — Бібліогр.: 21 назв. — англ.

In childhood tumors, including retinoblastoma, osteosarcoma, and neuroblastoma, the RB-E2F1 pathway is inactivated, as a rule. These tumors arise from precursor cells that fail to undergo the terminal differentiation. Noteworthy, the RB1-encoded protein (RB) does not control the cell cycle in embryo...