A study of transferrin and ferritin expression in tumor cells of patients with breast cancer
Aim: to study and to evaluate the clinical significance of the expression of iron-containing proteins ferritin and transferrin in tumor cells of patients with breast cancer (BC). Object and methods: the study included 143 patients with BC stage II–III. Methods: clinical, morphological and immunoh...
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| Datum: | 2014 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2014
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| Schriftenreihe: | Онкологія |
| Schlagworte: | |
| Online Zugang: | https://nasplib.isofts.kiev.ua/handle/123456789/137624 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | A study of transferrin and ferritin expression in tumor cells of patients with breast cancer / O.V. Shepil, N.Y. Lukyanova, S.V. Chekhun, L.Z. Polishchuk, S.V. Antipova // Онкологія. — 2014. — Т. 16, № 2. — С. 108-112. — Бібліогр.: 35 назв. — англ. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Zusammenfassung: | Aim: to study and to evaluate the clinical significance of the expression
of iron-containing proteins ferritin and transferrin in tumor cells of patients with
breast cancer (BC). Object and methods: the study included 143 patients with BC
stage II–III. Methods: clinical, morphological and immunohistochemical, statistical.
Results: it was shown that BC is characterized by intertumor heterogeneity
of expression of transferrin and ferritin. The high degree of differentiation
of BC correlates with the lack of expression of transferrin and ferritin. Positive expression
of these proteins in the cells of primary tumors correlated with the development
of metastases in regional lymphatic nodes. Correlation dependences between
parameters of expression of transferrin and ferritin in tumor cells and overall
survival in patients with BC have been determined. Conclusions: the expression
of transferrin and ferritin may be individual predictive markers of clinical course
and survival in patients with BC and one more molecular target for the development
of new anticancer agents. |
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