Current epidemiological knowledge about the role of flavonoids in prostate carcinogenesis
Numerous experimental studies have demonstrated anticancer action of polyphenolic plant metabolites. However, data about associations between dietary intake of plant-derived flavonoids and prostate cancer risk are still sparse and inconsistent. This minireview compiles the epidemiological findings p...
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| Published in: | Experimental Oncology |
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| Date: | 2017 |
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| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2017
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/137628 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Current epidemiological knowledge about the role of flavonoids in prostate carcinogenesis / K. Sak // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 98–105. — Бібліогр.: 38 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
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Sak, K. 2018-06-17T14:18:01Z 2018-06-17T14:18:01Z 2017 Current epidemiological knowledge about the role of flavonoids in prostate carcinogenesis / K. Sak // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 98–105. — Бібліогр.: 38 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/137628 Numerous experimental studies have demonstrated anticancer action of polyphenolic plant metabolites. However, data about associations between dietary intake of plant-derived flavonoids and prostate cancer risk are still sparse and inconsistent. This minireview compiles the epidemiological findings published to date on the role of flavonoids in prostate tumorigenesis, discusses the reasons of inconsistencies and elicits the promising results for chemoprevention of this malignancy. Long-term consumption of high doses of soy isoflavones can be the reason of markedly lower clinically detectable prostate cancer incidence among Asian men compared to their counterparts in the Western world. The ability to metabolize daidzein to equol, the most biologically active isoflavone, by the certain intestinal bacteria also seems to contribute to this important health benefit. The increasing incidence rate of prostate cancer related to adoption of westernized lifestyle and dietary habits makes the issue of chemoprevention ever more important and directs the eyes to specific food components in the Eastern diet. If further large-scale epidemiological studies will confirm the protective effects of isoflavones against prostate cancer, this could provide an important way for prostate cancer prevention, as diet is a potentially modifiable factor in our behavioral pattern. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews Current epidemiological knowledge about the role of flavonoids in prostate carcinogenesis Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Current epidemiological knowledge about the role of flavonoids in prostate carcinogenesis |
| spellingShingle |
Current epidemiological knowledge about the role of flavonoids in prostate carcinogenesis Sak, K. Reviews |
| title_short |
Current epidemiological knowledge about the role of flavonoids in prostate carcinogenesis |
| title_full |
Current epidemiological knowledge about the role of flavonoids in prostate carcinogenesis |
| title_fullStr |
Current epidemiological knowledge about the role of flavonoids in prostate carcinogenesis |
| title_full_unstemmed |
Current epidemiological knowledge about the role of flavonoids in prostate carcinogenesis |
| title_sort |
current epidemiological knowledge about the role of flavonoids in prostate carcinogenesis |
| author |
Sak, K. |
| author_facet |
Sak, K. |
| topic |
Reviews |
| topic_facet |
Reviews |
| publishDate |
2017 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Numerous experimental studies have demonstrated anticancer action of polyphenolic plant metabolites. However, data about associations between dietary intake of plant-derived flavonoids and prostate cancer risk are still sparse and inconsistent. This minireview compiles the epidemiological findings published to date on the role of flavonoids in prostate tumorigenesis, discusses the reasons of inconsistencies and elicits the promising results for chemoprevention of this malignancy. Long-term consumption of high doses of soy isoflavones can be the reason of markedly lower clinically detectable prostate cancer incidence among Asian men compared to their counterparts in the Western world. The ability to metabolize daidzein to equol, the most biologically active isoflavone, by the certain intestinal bacteria also seems to contribute to this important health benefit. The increasing incidence rate of prostate cancer related to adoption of westernized lifestyle and dietary habits makes the issue of chemoprevention ever more important and directs the eyes to specific food components in the Eastern diet. If further large-scale epidemiological studies will confirm the protective effects of isoflavones against prostate cancer, this could provide an important way for prostate cancer prevention, as diet is a potentially modifiable factor in our behavioral pattern.
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/137628 |
| citation_txt |
Current epidemiological knowledge about the role of flavonoids in prostate carcinogenesis / K. Sak // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 98–105. — Бібліогр.: 38 назв. — англ. |
| work_keys_str_mv |
AT sakk currentepidemiologicalknowledgeabouttheroleofflavonoidsinprostatecarcinogenesis |
| first_indexed |
2025-12-07T15:56:15Z |
| last_indexed |
2025-12-07T15:56:15Z |
| _version_ |
1850865589437857792 |