Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability
Aim: The article presents the results of developing the composition and technology of obtaining the liposomal form of docetaxel. The effect of the phospholipid composition of the membrane, ionic strength, pH, temperature, cryoprotectant type, and other factors on the stability of liposomes and the d...
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2017 |
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| Format: | Artikel |
| Sprache: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2017
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| Online Zugang: | https://nasplib.isofts.kiev.ua/handle/123456789/137633 |
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| Zitieren: | Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability / Y.M. Krasnopolsky, А.S. Dudnichenko // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 121-123. — Бібліогр.: 22 назв. — англ. |
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Krasnopolsky, Y.M. Dudnichenko, A.S. 2018-06-17T14:23:12Z 2018-06-17T14:23:12Z 2017 Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability / Y.M. Krasnopolsky, А.S. Dudnichenko // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 121-123. — Бібліогр.: 22 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/137633 Aim: The article presents the results of developing the composition and technology of obtaining the liposomal form of docetaxel. The effect of the phospholipid composition of the membrane, ionic strength, pH, temperature, cryoprotectant type, and other factors on the stability of liposomes and the docetaxel incorporation has been considered. Results: Reduction of toxicity of the liposomal form of docetaxel (LD₅₀ — 137 ± 7.7 mg/kg) was found in comparison with its free form (LD₅₀ — 101 ± 6.3 mg/kg). Preservation of nanosize particle after lyophilization has been shown. Conclusions: As a result of the studies, the optimal composition and technological scheme for obtaining liposomes containing docetaxel have been developed allowing large-scale production of docetaxel in liposomal form. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability Article published earlier |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
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| title |
Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability |
| spellingShingle |
Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability Krasnopolsky, Y.M. Dudnichenko, A.S. Original contributions |
| title_short |
Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability |
| title_full |
Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability |
| title_fullStr |
Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability |
| title_full_unstemmed |
Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability |
| title_sort |
experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability |
| author |
Krasnopolsky, Y.M. Dudnichenko, A.S. |
| author_facet |
Krasnopolsky, Y.M. Dudnichenko, A.S. |
| topic |
Original contributions |
| topic_facet |
Original contributions |
| publishDate |
2017 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Aim: The article presents the results of developing the composition and technology of obtaining the liposomal form of docetaxel. The effect of the phospholipid composition of the membrane, ionic strength, pH, temperature, cryoprotectant type, and other factors on the stability of liposomes and the docetaxel incorporation has been considered. Results: Reduction of toxicity of the liposomal form of docetaxel (LD₅₀ — 137 ± 7.7 mg/kg) was found in comparison with its free form (LD₅₀ — 101 ± 6.3 mg/kg). Preservation of nanosize particle after lyophilization has been shown. Conclusions: As a result of the studies, the optimal composition and technological scheme for obtaining liposomes containing docetaxel have been developed allowing large-scale production of docetaxel in liposomal form.
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/137633 |
| citation_txt |
Experimental study of liposomal docetaxel analysis of docetaxel incorporation and stability / Y.M. Krasnopolsky, А.S. Dudnichenko // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 121-123. — Бібліогр.: 22 назв. — англ. |
| work_keys_str_mv |
AT krasnopolskyym experimentalstudyofliposomaldocetaxelanalysisofdocetaxelincorporationandstability AT dudnichenkoas experimentalstudyofliposomaldocetaxelanalysisofdocetaxelincorporationandstability |
| first_indexed |
2025-12-01T00:27:06Z |
| last_indexed |
2025-12-01T00:27:06Z |
| _version_ |
1850858910866472960 |