Circulating hematopoietic progenitor cells in patients affected by chornobyl accident
High radiation sensitivity of stem cells and their ability to accumulate sublethal radiation damage provides the basis for investigation of hematopoietic progenitors using in vivo culture methodology. Unique samples of peripheral blood and bone marrow were derived from the patients affected by Chorn...
Збережено в:
| Опубліковано в: : | Experimental Oncology |
|---|---|
| Дата: | 2016 |
| Автори: | , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2016
|
| Теми: | |
| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/137686 |
| Теги: |
Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Circulating hematopoietic progenitor cells in patients affected by chornobyl accident / N.M. Bilko, I.S. Dyagil, I.Z. Russu, D.I. Bilko // Experimental Oncology. — 2016 — Т. 38, № 4. — С. 242-244. — Бібліогр.: 10 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
nasplib_isofts_kiev_ua-123456789-137686 |
|---|---|
| record_format |
dspace |
| spelling |
Bilko, N.M. Dyagil, I.S. Russu, I.Z. Bilko, D.I. 2018-06-17T15:02:17Z 2018-06-17T15:02:17Z 2016 Circulating hematopoietic progenitor cells in patients affected by chornobyl accident / N.M. Bilko, I.S. Dyagil, I.Z. Russu, D.I. Bilko // Experimental Oncology. — 2016 — Т. 38, № 4. — С. 242-244. — Бібліогр.: 10 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/137686 High radiation sensitivity of stem cells and their ability to accumulate sublethal radiation damage provides the basis for investigation of hematopoietic progenitors using in vivo culture methodology. Unique samples of peripheral blood and bone marrow were derived from the patients affected by Chornobyl accident during liquidation campaign. Aim: To investigate functional activity of circulating hematopoietic progenitor cells from peripheral blood and bone marrow of cleanup workers in early and remote periods after the accident at Chornobyl nuclear power plant (CNPP). Materials and Methods: The assessment of the functional activity of circulating hematopoietic progenitor cells was performed in samples of peripheral blood and bone marrow of 46 cleanup workers, who were treated in the National Scientific Center for Radiation Medicine of the Academy of Medical Sciences of Ukraine alongside with 35 non radiated patients, who served as a control. Work was performed by culturing peripheral blood and bone marrow mononuclear cells in the original gel diffusion capsules, implanted into the peritoneal cavity of CBA mice. Results: It was shown that hematopoietic progenitor cells could be identified in the peripheral blood of liquidators of CNPP accident. At the same time the number of functionally active progenitor cells of the bone marrow was significantly decreased and during the next 10 years after the accident, counts of circulating progenitor cells in the peripheral blood as well as functionally active hematopoietic cells in bone marrow returned to normal levels. Conclusion: It was shown that hematopoietic progenitor cells are detected not only in the bone marrow but also in the peripheral blood of liquidators as a consequence of radiation exposure associated with CNPP accident. This article is a part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Circulating hematopoietic progenitor cells in patients affected by chornobyl accident Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Circulating hematopoietic progenitor cells in patients affected by chornobyl accident |
| spellingShingle |
Circulating hematopoietic progenitor cells in patients affected by chornobyl accident Bilko, N.M. Dyagil, I.S. Russu, I.Z. Bilko, D.I. Original contributions |
| title_short |
Circulating hematopoietic progenitor cells in patients affected by chornobyl accident |
| title_full |
Circulating hematopoietic progenitor cells in patients affected by chornobyl accident |
| title_fullStr |
Circulating hematopoietic progenitor cells in patients affected by chornobyl accident |
| title_full_unstemmed |
Circulating hematopoietic progenitor cells in patients affected by chornobyl accident |
| title_sort |
circulating hematopoietic progenitor cells in patients affected by chornobyl accident |
| author |
Bilko, N.M. Dyagil, I.S. Russu, I.Z. Bilko, D.I. |
| author_facet |
Bilko, N.M. Dyagil, I.S. Russu, I.Z. Bilko, D.I. |
| topic |
Original contributions |
| topic_facet |
Original contributions |
| publishDate |
2016 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
High radiation sensitivity of stem cells and their ability to accumulate sublethal radiation damage provides the basis for investigation of hematopoietic progenitors using in vivo culture methodology. Unique samples of peripheral blood and bone marrow were derived from the patients affected by Chornobyl accident during liquidation campaign. Aim: To investigate functional activity of circulating hematopoietic progenitor cells from peripheral blood and bone marrow of cleanup workers in early and remote periods after the accident at Chornobyl nuclear power plant (CNPP). Materials and Methods: The assessment of the functional activity of circulating hematopoietic progenitor cells was performed in samples of peripheral blood and bone marrow of 46 cleanup workers, who were treated in the National Scientific Center for Radiation Medicine of the Academy of Medical Sciences of Ukraine alongside with 35 non radiated patients, who served as a control. Work was performed by culturing peripheral blood and bone marrow mononuclear cells in the original gel diffusion capsules, implanted into the peritoneal cavity of CBA mice. Results: It was shown that hematopoietic progenitor cells could be identified in the peripheral blood of liquidators of CNPP accident. At the same time the number of functionally active progenitor cells of the bone marrow was significantly decreased and during the next 10 years after the accident, counts of circulating progenitor cells in the peripheral blood as well as functionally active hematopoietic cells in bone marrow returned to normal levels. Conclusion: It was shown that hematopoietic progenitor cells are detected not only in the bone marrow but also in the peripheral blood of liquidators as a consequence of radiation exposure associated with CNPP accident. This article is a part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”.
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/137686 |
| citation_txt |
Circulating hematopoietic progenitor cells in patients affected by chornobyl accident / N.M. Bilko, I.S. Dyagil, I.Z. Russu, D.I. Bilko // Experimental Oncology. — 2016 — Т. 38, № 4. — С. 242-244. — Бібліогр.: 10 назв. — англ. |
| work_keys_str_mv |
AT bilkonm circulatinghematopoieticprogenitorcellsinpatientsaffectedbychornobylaccident AT dyagilis circulatinghematopoieticprogenitorcellsinpatientsaffectedbychornobylaccident AT russuiz circulatinghematopoieticprogenitorcellsinpatientsaffectedbychornobylaccident AT bilkodi circulatinghematopoieticprogenitorcellsinpatientsaffectedbychornobylaccident |
| first_indexed |
2025-12-07T16:12:40Z |
| last_indexed |
2025-12-07T16:12:40Z |
| _version_ |
1850866622522195968 |