Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease

Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease

Aim: To determine the patterns of lactoferrin (LF) expression in breast cancer (BC) in relation to biologic properties of the neoplasms and clinical features of the disease course. Materials and Methods: Clinical specimens of 266 BC patients (115 patients with BC of stages I–II — retrospective study...

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Опубліковано в: :Experimental Oncology
Дата:2016
Автори: Naleskina, L.A., Lukianova, N.Yu., Sobchenko, S.O., Storchai, D.M., Chekhun, V.F.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2016
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Original contributions
Онлайн доступ:https://nasplib.isofts.kiev.ua/handle/123456789/137731
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease / L.A. Naleskina, N.Yu. Lukianova, S.O. Sobchenko, D.M. Storchai, V.F. Chekhun // Experimental Oncology. — 2016 — Т. 38, № 3. — С. 181-186. — Бібліогр.: 35 назв. — англ.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-137731
record_format dspace
spelling Naleskina, L.A.
Lukianova, N.Yu.
Sobchenko, S.O.
Storchai, D.M.
Chekhun, V.F.
2018-06-17T15:43:29Z
2018-06-17T15:43:29Z
2016
Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease / L.A. Naleskina, N.Yu. Lukianova, S.O. Sobchenko, D.M. Storchai, V.F. Chekhun // Experimental Oncology. — 2016 — Т. 38, № 3. — С. 181-186. — Бібліогр.: 35 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/137731
Aim: To determine the patterns of lactoferrin (LF) expression in breast cancer (BC) in relation to biologic properties of the neoplasms and clinical features of the disease course. Materials and Methods: Clinical specimens of 266 BC patients (115 patients with BC of stages I–II — retrospective study, and 151 BC patients — prospective study) were analyzed. Morphological, immunohistochemical and statistical methods were used. Results: The number of LF-positive tumors in retrospective and prospective groups was similar (52.1 and 52.8%, respectively). Among common clinical criteria for prognosis of the disease outcome in BC patients (patient’s age; stage of the disease; histological type, differentiation grade, receptor status; presence of metastases), a strong correlation was found only between expression indexes of LF and estrogen receptors (ER). In ER-positive tumors expression of LF was significantly higher than in ER-negative tumors (35 vs 18%). 5-Year survival rate of BC patients was higher in LF-positive group (70 vs 52% in LF-negative group). The presence of regional metastasis tended to correlate with an increased number of LF-positive tumors. In the patients with invasive ductal carcinoma, expression level of LF moderately correlated with occurrence of luminal A subtype (r = 0.43), while in the patients with invasive lobular carcinoma this index strongly correlated with occurrence of luminal B subtype (r = 0.71). LF expression correlated positively with low and moderate differentiation grade of luminal B or basal tumors, and negatively with luminal B or basal tumors of high differentiation grade (r = −0.57 and −0.63, respectively). Conclusion: It has been shown that LF expression in breast tumors correlated with life expectancy of BC patients and important physiologic and clinical features of the disease, while the character of such relation strongly depended on molecular phenotype of tumor, i.e. luminal A, luminal B or basal.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease
spellingShingle Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease
Naleskina, L.A.
Lukianova, N.Yu.
Sobchenko, S.O.
Storchai, D.M.
Chekhun, V.F.
Original contributions
title_short Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease
title_full Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease
title_fullStr Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease
title_full_unstemmed Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease
title_sort lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease
author Naleskina, L.A.
Lukianova, N.Yu.
Sobchenko, S.O.
Storchai, D.M.
Chekhun, V.F.
author_facet Naleskina, L.A.
Lukianova, N.Yu.
Sobchenko, S.O.
Storchai, D.M.
Chekhun, V.F.
topic Original contributions
topic_facet Original contributions
publishDate 2016
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: To determine the patterns of lactoferrin (LF) expression in breast cancer (BC) in relation to biologic properties of the neoplasms and clinical features of the disease course. Materials and Methods: Clinical specimens of 266 BC patients (115 patients with BC of stages I–II — retrospective study, and 151 BC patients — prospective study) were analyzed. Morphological, immunohistochemical and statistical methods were used. Results: The number of LF-positive tumors in retrospective and prospective groups was similar (52.1 and 52.8%, respectively). Among common clinical criteria for prognosis of the disease outcome in BC patients (patient’s age; stage of the disease; histological type, differentiation grade, receptor status; presence of metastases), a strong correlation was found only between expression indexes of LF and estrogen receptors (ER). In ER-positive tumors expression of LF was significantly higher than in ER-negative tumors (35 vs 18%). 5-Year survival rate of BC patients was higher in LF-positive group (70 vs 52% in LF-negative group). The presence of regional metastasis tended to correlate with an increased number of LF-positive tumors. In the patients with invasive ductal carcinoma, expression level of LF moderately correlated with occurrence of luminal A subtype (r = 0.43), while in the patients with invasive lobular carcinoma this index strongly correlated with occurrence of luminal B subtype (r = 0.71). LF expression correlated positively with low and moderate differentiation grade of luminal B or basal tumors, and negatively with luminal B or basal tumors of high differentiation grade (r = −0.57 and −0.63, respectively). Conclusion: It has been shown that LF expression in breast tumors correlated with life expectancy of BC patients and important physiologic and clinical features of the disease, while the character of such relation strongly depended on molecular phenotype of tumor, i.e. luminal A, luminal B or basal.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/137731
citation_txt Lactoferrin expression in breast cancer in relation to biologic properties of tumors and clinical features of disease / L.A. Naleskina, N.Yu. Lukianova, S.O. Sobchenko, D.M. Storchai, V.F. Chekhun // Experimental Oncology. — 2016 — Т. 38, № 3. — С. 181-186. — Бібліогр.: 35 назв. — англ.
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AT sobchenkoso lactoferrinexpressioninbreastcancerinrelationtobiologicpropertiesoftumorsandclinicalfeaturesofdisease
AT storchaidm lactoferrinexpressioninbreastcancerinrelationtobiologicpropertiesoftumorsandclinicalfeaturesofdisease
AT chekhunvf lactoferrinexpressioninbreastcancerinrelationtobiologicpropertiesoftumorsandclinicalfeaturesofdisease
first_indexed 2025-12-07T18:32:23Z
last_indexed 2025-12-07T18:32:23Z
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