Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity
Today due to improvements in cancer treatment there is an increasing number of long-term cancer survivors, many of whom suffer from infertility caused by malignancy itself and chemo- or radiotherapy. Also, anticancer therapy may cause myelosuppression. Presently granulocyte colony stimulating factor...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2016 |
| Автори: | , , , , , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2016
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/137734 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity / O.O. Shevchuk, Ya.Ya. Bodnar, K.I. Bardakhivska, T.V. Datsko, A.S. Volska, K.A. Posokhova, V.F. Chekhun, V.G. Nikolaev // Experimental Oncology. — 2016 — Т. 38, № 3. — С. 172–175. — Бібліогр.: 18 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862657569132118016 |
|---|---|
| author | Shevchuk, O.O. Bodnar, Ya.Ya. Bardakhivska, K.I. Datsko, T.V. Volska, A.S. Posokhova, K.A. Chekhun, V.F. Nikolaev, V.G. |
| author_facet | Shevchuk, O.O. Bodnar, Ya.Ya. Bardakhivska, K.I. Datsko, T.V. Volska, A.S. Posokhova, K.A. Chekhun, V.F. Nikolaev, V.G. |
| citation_txt | Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity / O.O. Shevchuk, Ya.Ya. Bodnar, K.I. Bardakhivska, T.V. Datsko, A.S. Volska, K.A. Posokhova, V.F. Chekhun, V.G. Nikolaev // Experimental Oncology. — 2016 — Т. 38, № 3. — С. 172–175. — Бібліогр.: 18 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Today due to improvements in cancer treatment there is an increasing number of long-term cancer survivors, many of whom suffer from infertility caused by malignancy itself and chemo- or radiotherapy. Also, anticancer therapy may cause myelosuppression. Presently granulocyte colony stimulating factor (G-CSF) is used for prevention and treatment of myelosuppression. Another treatment option used to decrease intoxication and ameliorate side effects of cancer therapy is sorption technology. The aim of our investigation was to study the efficiency of combined use of enterosorption and G-CSF to decrease gonadal toxicity of chemotherapy. Materials and Methods: Melphalan (L-PAM) injected i.v. at a single dose of 4 mg/kg to white inbred rats was used as gonadotoxic and myelosuppressing agent. Carbon enterosorbent C2 was administered by intragastric route as a suspension in saline at a dose of 5 ml per 1 kg of rats’ body weight (or 900 mg/kg of the dry mass of enterosorbent) daily for 3 days before and for 7 days after L-PAM injection. G-CSF was injected once a day for 4 days starting from the next day after L-PAM administration at a dose of 50 µg/kg. Histological preparations of testicular tissues were examined by light microscopy. Results: Our findings have shown that melphalan caused marked damage of testicular tissues and seminiferous, especially spermatogenic epithelium. The most expressed protection of the histological structure of testes was observed when enterosorbent and G-CSF were used in combination. Conclusion: Gonadal toxicity of chemotherapy could be efficiently decreased by the combined use of enterosorption and G-CSF.
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| first_indexed | 2025-12-02T07:00:45Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-137734 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-02T07:00:45Z |
| publishDate | 2016 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Shevchuk, O.O. Bodnar, Ya.Ya. Bardakhivska, K.I. Datsko, T.V. Volska, A.S. Posokhova, K.A. Chekhun, V.F. Nikolaev, V.G. 2018-06-17T15:44:03Z 2018-06-17T15:44:03Z 2016 Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity / O.O. Shevchuk, Ya.Ya. Bodnar, K.I. Bardakhivska, T.V. Datsko, A.S. Volska, K.A. Posokhova, V.F. Chekhun, V.G. Nikolaev // Experimental Oncology. — 2016 — Т. 38, № 3. — С. 172–175. — Бібліогр.: 18 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/137734 Today due to improvements in cancer treatment there is an increasing number of long-term cancer survivors, many of whom suffer from infertility caused by malignancy itself and chemo- or radiotherapy. Also, anticancer therapy may cause myelosuppression. Presently granulocyte colony stimulating factor (G-CSF) is used for prevention and treatment of myelosuppression. Another treatment option used to decrease intoxication and ameliorate side effects of cancer therapy is sorption technology. The aim of our investigation was to study the efficiency of combined use of enterosorption and G-CSF to decrease gonadal toxicity of chemotherapy. Materials and Methods: Melphalan (L-PAM) injected i.v. at a single dose of 4 mg/kg to white inbred rats was used as gonadotoxic and myelosuppressing agent. Carbon enterosorbent C2 was administered by intragastric route as a suspension in saline at a dose of 5 ml per 1 kg of rats’ body weight (or 900 mg/kg of the dry mass of enterosorbent) daily for 3 days before and for 7 days after L-PAM injection. G-CSF was injected once a day for 4 days starting from the next day after L-PAM administration at a dose of 50 µg/kg. Histological preparations of testicular tissues were examined by light microscopy. Results: Our findings have shown that melphalan caused marked damage of testicular tissues and seminiferous, especially spermatogenic epithelium. The most expressed protection of the histological structure of testes was observed when enterosorbent and G-CSF were used in combination. Conclusion: Gonadal toxicity of chemotherapy could be efficiently decreased by the combined use of enterosorption and G-CSF. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity Article published earlier |
| spellingShingle | Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity Shevchuk, O.O. Bodnar, Ya.Ya. Bardakhivska, K.I. Datsko, T.V. Volska, A.S. Posokhova, K.A. Chekhun, V.F. Nikolaev, V.G. Original contributions |
| title | Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity |
| title_full | Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity |
| title_fullStr | Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity |
| title_full_unstemmed | Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity |
| title_short | Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity |
| title_sort | enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/137734 |
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