Adenocarcinoma of the lung with rare insertion mutation in egfr exon 19 that had partial response to gefitinib: a case report

• Datum: 2017
• Hauptverfasser: Kozlov, V., Karpov, I., Kovalenko, S., Shamanin, V.
• Format: Artikel
• Sprache: English
• Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2017
• Schriftenreihe: Experimental Oncology
• Schlagworte: Case report
• Online Zugang: https://nasplib.isofts.kiev.ua/handle/123456789/137971
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Zitieren: Adenocarcinoma of the lung with rare insertion mutation in egfr exon 19 that had partial response to gefitinib: a case report / V. Kozlov, I. Karpov, S. Kovalenko, V. Shamani // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 155–156. — Бібліогр.: 7 назв. — англ.

Aim: Classic activating mutations L858R and deletions in exon 19 (19del) in the gene for epidermal growth factor receptor (EGFR) are associated with sensitivity of the non-small cell lung cancer (NSCLC) to therapy with tyrosine kinase inhibitors (TKI). Insertions in EGFR exon 19 (19ins) are rare mut...