Genome-wide association study of loss of heterozygosity and metastasis-free survival in breast cancer patients

• Published in: Experimental Oncology
• Date: 2017
• Main Authors: Deryusheva, I.V., Tsyganov, M.M., Garbukov, E.Y., Ibragimova, M.K., Kzhyshkovska, Ju.G., Slonimskaya, E.M., Cherdyntseva, N.V., Litviakov, N.V.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2017
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/137975
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Genome-wide association study of loss of heterozygosity and metastasis-free survival in breast cancer patients / I.V. Deryusheva, M.M. Tsyganov, E.Y. Garbukov, M.K. Ibragimova, Ju.G. Kzhyshkovska, Е.М. Slonimskaya, N.V. Cherdyntseva, N.V. Litviakov // Experimental Oncology. — 2017 — Т. 39, № 2. — С. 145–150. — Бібліогр.: 34 назв. — англ.

One of the factors providing the diversity and heterogeneity of malignant tumors, particularly breast cancer, are genetic variations, due to gene polymorphism, and, especially, the phenomenon of loss of heterozygosity (LOH). It has been shown that LOH in some genes could be a good prognostic marker....