A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice
Background: Brain tumors are highly aggressive tumors characterized by secretions of high levels of matrix metalloproteinase-2 and -9, leading to tumor growth, invasion and metastasis by digesting the basement membrane and extracellular matrix components. We previously demonstrated the effectiveness...
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| Published in: | Experimental Oncology |
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| Date: | 2016 |
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2016
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/137980 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice / M.W. Roomi, T. Kalinovsky, M. Rath, A. Niedzwiecki // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 54–56. — Бібліогр.: 9 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862729762342961152 |
|---|---|
| author | Roomi, M.W. Kalinovsky, T. Rath, M. Niedzwiecki, A. |
| author_facet | Roomi, M.W. Kalinovsky, T. Rath, M. Niedzwiecki, A. |
| citation_txt | A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice / M.W. Roomi, T. Kalinovsky, M. Rath, A. Niedzwiecki // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 54–56. — Бібліогр.: 9 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Background: Brain tumors are highly aggressive tumors characterized by secretions of high levels of matrix metalloproteinase-2 and -9, leading to tumor growth, invasion and metastasis by digesting the basement membrane and extracellular matrix components. We previously demonstrated the effectiveness of a nutrient mixture (NM) containing ascorbic acid, lysine, proline, and green tea extract in vitro: on activity of urokinase plasminogen activator, matrix metalloproteinases and TIMPs in various human glioblastoma (LN-18, T-98G and A-172) cell lines and on glioblastoma A-172 cell proliferation and Matrigel invasion. Aim: Our main objective in this study was to investigate the effect of the NM in vivo on human glioblastoma U-87 MG cell line. Materials and Methods: Athymic male nude mice inoculated with 3·106 U-87 MG cells subcutaneously and were fed a regular diet or a regular diet supplemented with 0.5% NM. Four weeks later, the mice were sacrificed, the tumors were weighed and measured. The samples were studied histologically. Results: NM inhibited tumor weight and tumor burden by 53% (p = 0.015) and 48% (p = 0.010), respectively. Conclusions: These results suggest the therapeutic potential of NM as an adjuvant in the treatment of glioblastoma.
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| first_indexed | 2025-12-07T19:17:09Z |
| format | Article |
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| id | nasplib_isofts_kiev_ua-123456789-137980 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T19:17:09Z |
| publishDate | 2016 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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| spelling | Roomi, M.W. Kalinovsky, T. Rath, M. Niedzwiecki, A. 2018-06-17T20:12:12Z 2018-06-17T20:12:12Z 2016 A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice / M.W. Roomi, T. Kalinovsky, M. Rath, A. Niedzwiecki // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 54–56. — Бібліогр.: 9 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/137980 Background: Brain tumors are highly aggressive tumors characterized by secretions of high levels of matrix metalloproteinase-2 and -9, leading to tumor growth, invasion and metastasis by digesting the basement membrane and extracellular matrix components. We previously demonstrated the effectiveness of a nutrient mixture (NM) containing ascorbic acid, lysine, proline, and green tea extract in vitro: on activity of urokinase plasminogen activator, matrix metalloproteinases and TIMPs in various human glioblastoma (LN-18, T-98G and A-172) cell lines and on glioblastoma A-172 cell proliferation and Matrigel invasion. Aim: Our main objective in this study was to investigate the effect of the NM in vivo on human glioblastoma U-87 MG cell line. Materials and Methods: Athymic male nude mice inoculated with 3·106 U-87 MG cells subcutaneously and were fed a regular diet or a regular diet supplemented with 0.5% NM. Four weeks later, the mice were sacrificed, the tumors were weighed and measured. The samples were studied histologically. Results: NM inhibited tumor weight and tumor burden by 53% (p = 0.015) and 48% (p = 0.010), respectively. Conclusions: These results suggest the therapeutic potential of NM as an adjuvant in the treatment of glioblastoma. The research study was funded by Dr. Rath Health Foundation (Santa Clara, CA, USA), a non-profit organization. We thank consulting pathologist Alexander de Paoli, DVM, PhD, IDEXX Reference Laboratories for providing histopathology slides. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Short communications A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice Article published earlier |
| spellingShingle | A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice Roomi, M.W. Kalinovsky, T. Rath, M. Niedzwiecki, A. Short communications |
| title | A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice |
| title_full | A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice |
| title_fullStr | A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice |
| title_full_unstemmed | A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice |
| title_short | A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice |
| title_sort | nutrient mixture inhibits glioblastoma xenograft u-87 mg growth in male nude mice |
| topic | Short communications |
| topic_facet | Short communications |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/137980 |
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