Combined use of haemostatic system indices for evaluation of upper respiratory tract cancer progression
Aim: To analyze whether comprehensive assessment of haemostatic system components, in particular, indices of coagulation and fibrinolytic systems along with functionally related proteins, could be indicative of upper respiratory tract (URT) cancer progression. Materials and Methods: Indices of coagu...
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| Published in: | Experimental Oncology |
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| Date: | 2016 |
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2016
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/137983 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Combined use of haemostatic system indices for evaluation of upper respiratory tract cancer progression / Y.G. Klys, N.V. Gryn, S.V. Verevka // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 36–39. — Бібліогр.: 30 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862558178138390528 |
|---|---|
| author | Klys, Y.G. Gryn, N.V. Verevka, S.V. |
| author_facet | Klys, Y.G. Gryn, N.V. Verevka, S.V. |
| citation_txt | Combined use of haemostatic system indices for evaluation of upper respiratory tract cancer progression / Y.G. Klys, N.V. Gryn, S.V. Verevka // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 36–39. — Бібліогр.: 30 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: To analyze whether comprehensive assessment of haemostatic system components, in particular, indices of coagulation and fibrinolytic systems along with functionally related proteins, could be indicative of upper respiratory tract (URT) cancer progression. Materials and Methods: Indices of coagulation and fibrinolytic systems along with functionally related proteins, in particular, trypsinlike amidolytic activity, trypsin-like proteolytic activity, thrombin-like amidolytic activity, elastase-like amidolytic activity, fibrinolytic activity, potential amidolytic plasmin activity, content of fibrinogen, antithrombin III, α1-proteinase inhibitor, and α₂-macroglobulin, and prothrombin time were evaluated in blood plasma of patients with URT cancer of II (n = 10) and III (n = 25) stages with the use of routine biochemical methods. Results: For both groups of patients with URT cancer there have been shown notable differences for the majority of the studied indices, especially the indexes of proteolytic activities, from these of healthy donors, and in the case of URT cancer of III stage they reached statistical significance. In contrary, the changes in the content of antithrombin III, α₁-proteinase inhibitor, and α₂-macroglobulin were insignificant. In both groups of patients significant increase of fibrinogen content has been registered, while the content of soluble fibrinogen didn’t change. Also, in both groups of patients there a significant increase of potential activity of plasminogen was documented, while clot lysis time was significantly increased only in patients with III stage URT cancer. Multifactorial analysis of haemostatic system indices evidenced for efficacy of their combined use for evaluation of URT cancer progression risk. Conclusion: Combined use of fibrinogen and α₂-macroglobulin content and the level of amidolytic thrombinlike activity could serve as an indicator of URT cancer progression.
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| first_indexed | 2025-11-25T22:46:41Z |
| format | Article |
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| id | nasplib_isofts_kiev_ua-123456789-137983 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-25T22:46:41Z |
| publishDate | 2016 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Klys, Y.G. Gryn, N.V. Verevka, S.V. 2018-06-17T20:14:37Z 2018-06-17T20:14:37Z 2016 Combined use of haemostatic system indices for evaluation of upper respiratory tract cancer progression / Y.G. Klys, N.V. Gryn, S.V. Verevka // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 36–39. — Бібліогр.: 30 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/137983 Aim: To analyze whether comprehensive assessment of haemostatic system components, in particular, indices of coagulation and fibrinolytic systems along with functionally related proteins, could be indicative of upper respiratory tract (URT) cancer progression. Materials and Methods: Indices of coagulation and fibrinolytic systems along with functionally related proteins, in particular, trypsinlike amidolytic activity, trypsin-like proteolytic activity, thrombin-like amidolytic activity, elastase-like amidolytic activity, fibrinolytic activity, potential amidolytic plasmin activity, content of fibrinogen, antithrombin III, α1-proteinase inhibitor, and α₂-macroglobulin, and prothrombin time were evaluated in blood plasma of patients with URT cancer of II (n = 10) and III (n = 25) stages with the use of routine biochemical methods. Results: For both groups of patients with URT cancer there have been shown notable differences for the majority of the studied indices, especially the indexes of proteolytic activities, from these of healthy donors, and in the case of URT cancer of III stage they reached statistical significance. In contrary, the changes in the content of antithrombin III, α₁-proteinase inhibitor, and α₂-macroglobulin were insignificant. In both groups of patients significant increase of fibrinogen content has been registered, while the content of soluble fibrinogen didn’t change. Also, in both groups of patients there a significant increase of potential activity of plasminogen was documented, while clot lysis time was significantly increased only in patients with III stage URT cancer. Multifactorial analysis of haemostatic system indices evidenced for efficacy of their combined use for evaluation of URT cancer progression risk. Conclusion: Combined use of fibrinogen and α₂-macroglobulin content and the level of amidolytic thrombinlike activity could serve as an indicator of URT cancer progression. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Combined use of haemostatic system indices for evaluation of upper respiratory tract cancer progression Article published earlier |
| spellingShingle | Combined use of haemostatic system indices for evaluation of upper respiratory tract cancer progression Klys, Y.G. Gryn, N.V. Verevka, S.V. Original contributions |
| title | Combined use of haemostatic system indices for evaluation of upper respiratory tract cancer progression |
| title_full | Combined use of haemostatic system indices for evaluation of upper respiratory tract cancer progression |
| title_fullStr | Combined use of haemostatic system indices for evaluation of upper respiratory tract cancer progression |
| title_full_unstemmed | Combined use of haemostatic system indices for evaluation of upper respiratory tract cancer progression |
| title_short | Combined use of haemostatic system indices for evaluation of upper respiratory tract cancer progression |
| title_sort | combined use of haemostatic system indices for evaluation of upper respiratory tract cancer progression |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/137983 |
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