The level of IgG antibodies reactive to TF, Tn and Alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival
Background: The serum levels of IgG antibodies reactive to glycoconjugates (TF, Tn and αGal) were found to be associated with prognosis of gastrointestinal cancer patients. Aim: To study the relation between the levels of serum antibodies to TF-pAA, Tn-PAA and αGal-PAA polyacrylamide-based glycoconj...
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| Published in: | Experimental Oncology |
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| Date: | 2016 |
| Main Authors: | , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2016
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/137989 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | The level of IgG antibodies reactive to TF, Tn and Alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival / E.P. Smorodin, B.L. Sergeyev // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 117-121. — Бібліогр.: 31 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862546420606697472 |
|---|---|
| author | Smorodin, E.P. Sergeyev, B.L. |
| author_facet | Smorodin, E.P. Sergeyev, B.L. |
| citation_txt | The level of IgG antibodies reactive to TF, Tn and Alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival / E.P. Smorodin, B.L. Sergeyev // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 117-121. — Бібліогр.: 31 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Background: The serum levels of IgG antibodies reactive to glycoconjugates (TF, Tn and αGal) were found to be associated with prognosis of gastrointestinal cancer patients. Aim: To study the relation between the levels of serum antibodies to TF-pAA, Tn-PAA and αGal-PAA polyacrylamide-based glycoconjugates and survival in breast cancer. Materials and Methods: The preoperative level of IgG antibodies was analysed in the serum of patients (n = 59) using ELISA with polyacrylamide-glycoconjugates namely, TF-pAA (amide-type), and ethanolamide-conjugates Tn-PAA and αGal-PAA. Survival rate and hazard ratio (HR) were assessed by the Kaplan — Meier method and Cox univariate analysis in different pathomorphological groups. Results: Significantly better survival was observed in patients with an increased level of anti-TF-pAA antibodies both for all patients in total and groups in stages II–III; N1–2 and G3 (p = 0.008–0.021, HR = 0.18–0.23, mean survival time in months 164–186 vs 69–121). A trend to worse survival was observed in increased level of anti-Tn IgG (stages II–III) and anti-αGal IgG (G3): p = 0.075, HR = 2.49 and p = 0.066, HR = 3.27, respectively. Conclusion: The method for the determination of circulating anti-TF-pAA IgG may be a useful supplement in long-term prognostic assessment of patients with breast cancer.
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| first_indexed | 2025-11-25T12:45:32Z |
| format | Article |
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| id | nasplib_isofts_kiev_ua-123456789-137989 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-25T12:45:32Z |
| publishDate | 2016 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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| spelling | Smorodin, E.P. Sergeyev, B.L. 2018-06-17T20:26:46Z 2018-06-17T20:26:46Z 2016 The level of IgG antibodies reactive to TF, Tn and Alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival / E.P. Smorodin, B.L. Sergeyev // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 117-121. — Бібліогр.: 31 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/137989 Background: The serum levels of IgG antibodies reactive to glycoconjugates (TF, Tn and αGal) were found to be associated with prognosis of gastrointestinal cancer patients. Aim: To study the relation between the levels of serum antibodies to TF-pAA, Tn-PAA and αGal-PAA polyacrylamide-based glycoconjugates and survival in breast cancer. Materials and Methods: The preoperative level of IgG antibodies was analysed in the serum of patients (n = 59) using ELISA with polyacrylamide-glycoconjugates namely, TF-pAA (amide-type), and ethanolamide-conjugates Tn-PAA and αGal-PAA. Survival rate and hazard ratio (HR) were assessed by the Kaplan — Meier method and Cox univariate analysis in different pathomorphological groups. Results: Significantly better survival was observed in patients with an increased level of anti-TF-pAA antibodies both for all patients in total and groups in stages II–III; N1–2 and G3 (p = 0.008–0.021, HR = 0.18–0.23, mean survival time in months 164–186 vs 69–121). A trend to worse survival was observed in increased level of anti-Tn IgG (stages II–III) and anti-αGal IgG (G3): p = 0.075, HR = 2.49 and p = 0.066, HR = 3.27, respectively. Conclusion: The method for the determination of circulating anti-TF-pAA IgG may be a useful supplement in long-term prognostic assessment of patients with breast cancer. This study was supported by a grant № 8399 from the Estonian Science Foundation. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions The level of IgG antibodies reactive to TF, Tn and Alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival Article published earlier |
| spellingShingle | The level of IgG antibodies reactive to TF, Tn and Alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival Smorodin, E.P. Sergeyev, B.L. Original contributions |
| title | The level of IgG antibodies reactive to TF, Tn and Alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival |
| title_full | The level of IgG antibodies reactive to TF, Tn and Alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival |
| title_fullStr | The level of IgG antibodies reactive to TF, Tn and Alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival |
| title_full_unstemmed | The level of IgG antibodies reactive to TF, Tn and Alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival |
| title_short | The level of IgG antibodies reactive to TF, Tn and Alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival |
| title_sort | level of igg antibodies reactive to tf, tn and alpha-gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/137989 |
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