Effectiveness of sodium dichloroacetate against glioma с6 depends on administration schedule and dosage

• Published in: Experimental Oncology
• Date: 2016
• Main Authors: Fedorchuk, A.G., Pyaskovskaya, O.N., Gorbik, G.V., Prokhorova, I.V., Kolesnik, D.L., Solyanik, G.I.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2016
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/137992
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Effectiveness of sodium dichloroacetate against glioma с6 depends on administration schedule and dosage / A.G. Fedorchuk, O.N. Pyaskovskaya, G.V. Gorbik, I.V. Prokhorova, D.L. Kolesnik, G.I. Solyanik // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 80–83. — Бібліогр.: 23 назв. — англ.

Background: Anticancer action of sodium dichloroacetate (DCA) could be related to its ability to activate oxidative phosphorylation leading to enhanced generation of reactive oxygen species and induction of apoptosis. On the other hand, activation of oxidative phosphorylation could promote tumor cel...