Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes

Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes

The aim of the present study was to investigate the clinical and morphological features of nonspecific invasive breast cancer according to its molecular subtypes. Materials and Methods: 163 women with nonspecific invasive breast cancer (T1–4N0–3M0) were included in the present study. Luminal A type...

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Published in:Experimental Oncology
Date:2016
Main Authors: Zavyalova, M., Vtorushin, S., Telegina, N., Krakhmal, N., Savelieva, O., Tashireva, L., Bragina, O., Denisov, E., Kaigorodova, E., Slonimskaya, E., Choynzonov, E., Perelmuter, V.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2016
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Original contributions
Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/137996
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes / M. Zavyalova, S. Vtorushin, N. Telegina, N. Krakhmal, O. Savelieva, L. Tashireva, O. Bragina, E. Denisov, E. Kaigorodova, E. Slonimskaya, E. Choynzonov, V. Perelmuter // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 122–127. — Бібліогр.: 24 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-137996
record_format dspace
spelling Zavyalova, M.
Vtorushin, S.
Telegina, N.
Krakhmal, N.
Savelieva, O.
Tashireva, L.
Bragina, O.
Denisov, E.
Kaigorodova, E.
Slonimskaya, E.
Choynzonov, E.
Perelmuter, V.
2018-06-17T20:36:02Z
2018-06-17T20:36:02Z
2016
Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes / M. Zavyalova, S. Vtorushin, N. Telegina, N. Krakhmal, O. Savelieva, L. Tashireva, O. Bragina, E. Denisov, E. Kaigorodova, E. Slonimskaya, E. Choynzonov, V. Perelmuter // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 122–127. — Бібліогр.: 24 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/137996
The aim of the present study was to investigate the clinical and morphological features of nonspecific invasive breast cancer according to its molecular subtypes. Materials and Methods: 163 women with nonspecific invasive breast cancer (T1–4N0–3M0) were included in the present study. Luminal A type of breast cancer was detected in 101 women, luminal B type — in 23 women, overexpression of HER2/neu was identified in 14 women and triple-negative cancer — in 25 women. Results: The study revealed that various molecular subtypes of breast cancer differ in the morphological structure, the expression characteristics of the primary tumor and the rate of lymphogenous and hematogenous metastasis. Lymphogenous metastases were more frequently (in 71%) detected in HER2/neu overexpressing breast cancer than in luminal A (41%), luminal B (39%) and triple-negative tumors (40%). Hematogenous metastasis did not depend on the morphological structure of carcinoma infiltrative component, the state of tumor stroma as well as the proliferative activity in all the investigated groups. Conclusion: The revealed clinicopathological characteristics of different molecular subtypes of invasive breast cancer allow to predict the possible outcome of the disease and select personalized treatment strategy for patients more reasonably.
This work was supported by the Russian Foundation for Basic Research (project No. 15–34–20864 and 16–34–00415).
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes
spellingShingle Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes
Zavyalova, M.
Vtorushin, S.
Telegina, N.
Krakhmal, N.
Savelieva, O.
Tashireva, L.
Bragina, O.
Denisov, E.
Kaigorodova, E.
Slonimskaya, E.
Choynzonov, E.
Perelmuter, V.
Original contributions
title_short Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes
title_full Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes
title_fullStr Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes
title_full_unstemmed Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes
title_sort clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes
author Zavyalova, M.
Vtorushin, S.
Telegina, N.
Krakhmal, N.
Savelieva, O.
Tashireva, L.
Bragina, O.
Denisov, E.
Kaigorodova, E.
Slonimskaya, E.
Choynzonov, E.
Perelmuter, V.
author_facet Zavyalova, M.
Vtorushin, S.
Telegina, N.
Krakhmal, N.
Savelieva, O.
Tashireva, L.
Bragina, O.
Denisov, E.
Kaigorodova, E.
Slonimskaya, E.
Choynzonov, E.
Perelmuter, V.
topic Original contributions
topic_facet Original contributions
publishDate 2016
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description The aim of the present study was to investigate the clinical and morphological features of nonspecific invasive breast cancer according to its molecular subtypes. Materials and Methods: 163 women with nonspecific invasive breast cancer (T1–4N0–3M0) were included in the present study. Luminal A type of breast cancer was detected in 101 women, luminal B type — in 23 women, overexpression of HER2/neu was identified in 14 women and triple-negative cancer — in 25 women. Results: The study revealed that various molecular subtypes of breast cancer differ in the morphological structure, the expression characteristics of the primary tumor and the rate of lymphogenous and hematogenous metastasis. Lymphogenous metastases were more frequently (in 71%) detected in HER2/neu overexpressing breast cancer than in luminal A (41%), luminal B (39%) and triple-negative tumors (40%). Hematogenous metastasis did not depend on the morphological structure of carcinoma infiltrative component, the state of tumor stroma as well as the proliferative activity in all the investigated groups. Conclusion: The revealed clinicopathological characteristics of different molecular subtypes of invasive breast cancer allow to predict the possible outcome of the disease and select personalized treatment strategy for patients more reasonably.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/137996
citation_txt Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes / M. Zavyalova, S. Vtorushin, N. Telegina, N. Krakhmal, O. Savelieva, L. Tashireva, O. Bragina, E. Denisov, E. Kaigorodova, E. Slonimskaya, E. Choynzonov, V. Perelmuter // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 122–127. — Бібліогр.: 24 назв. — англ.
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first_indexed 2025-12-07T16:11:38Z
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