Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes
The aim of the present study was to investigate the clinical and morphological features of nonspecific invasive breast cancer according to its molecular subtypes. Materials and Methods: 163 women with nonspecific invasive breast cancer (T1–4N0–3M0) were included in the present study. Luminal A type...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2016 |
| Автори: | , , , , , , , , , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2016
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/137996 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes / M. Zavyalova, S. Vtorushin, N. Telegina, N. Krakhmal, O. Savelieva, L. Tashireva, O. Bragina, E. Denisov, E. Kaigorodova, E. Slonimskaya, E. Choynzonov, V. Perelmuter // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 122–127. — Бібліогр.: 24 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862689410264334336 |
|---|---|
| author | Zavyalova, M. Vtorushin, S. Telegina, N. Krakhmal, N. Savelieva, O. Tashireva, L. Bragina, O. Denisov, E. Kaigorodova, E. Slonimskaya, E. Choynzonov, E. Perelmuter, V. |
| author_facet | Zavyalova, M. Vtorushin, S. Telegina, N. Krakhmal, N. Savelieva, O. Tashireva, L. Bragina, O. Denisov, E. Kaigorodova, E. Slonimskaya, E. Choynzonov, E. Perelmuter, V. |
| citation_txt | Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes / M. Zavyalova, S. Vtorushin, N. Telegina, N. Krakhmal, O. Savelieva, L. Tashireva, O. Bragina, E. Denisov, E. Kaigorodova, E. Slonimskaya, E. Choynzonov, V. Perelmuter // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 122–127. — Бібліогр.: 24 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | The aim of the present study was to investigate the clinical and morphological features of nonspecific invasive breast cancer according to its molecular subtypes. Materials and Methods: 163 women with nonspecific invasive breast cancer (T1–4N0–3M0) were included in the present study. Luminal A type of breast cancer was detected in 101 women, luminal B type — in 23 women, overexpression of HER2/neu was identified in 14 women and triple-negative cancer — in 25 women. Results: The study revealed that various molecular subtypes of breast cancer differ in the morphological structure, the expression characteristics of the primary tumor and the rate of lymphogenous and hematogenous metastasis. Lymphogenous metastases were more frequently (in 71%) detected in HER2/neu overexpressing breast cancer than in luminal A (41%), luminal B (39%) and triple-negative tumors (40%). Hematogenous metastasis did not depend on the morphological structure of carcinoma infiltrative component, the state of tumor stroma as well as the proliferative activity in all the investigated groups. Conclusion: The revealed clinicopathological characteristics of different molecular subtypes of invasive breast cancer allow to predict the possible outcome of the disease and select personalized treatment strategy for patients more reasonably.
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| first_indexed | 2025-12-07T16:11:38Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-137996 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T16:11:38Z |
| publishDate | 2016 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Zavyalova, M. Vtorushin, S. Telegina, N. Krakhmal, N. Savelieva, O. Tashireva, L. Bragina, O. Denisov, E. Kaigorodova, E. Slonimskaya, E. Choynzonov, E. Perelmuter, V. 2018-06-17T20:36:02Z 2018-06-17T20:36:02Z 2016 Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes / M. Zavyalova, S. Vtorushin, N. Telegina, N. Krakhmal, O. Savelieva, L. Tashireva, O. Bragina, E. Denisov, E. Kaigorodova, E. Slonimskaya, E. Choynzonov, V. Perelmuter // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 122–127. — Бібліогр.: 24 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/137996 The aim of the present study was to investigate the clinical and morphological features of nonspecific invasive breast cancer according to its molecular subtypes. Materials and Methods: 163 women with nonspecific invasive breast cancer (T1–4N0–3M0) were included in the present study. Luminal A type of breast cancer was detected in 101 women, luminal B type — in 23 women, overexpression of HER2/neu was identified in 14 women and triple-negative cancer — in 25 women. Results: The study revealed that various molecular subtypes of breast cancer differ in the morphological structure, the expression characteristics of the primary tumor and the rate of lymphogenous and hematogenous metastasis. Lymphogenous metastases were more frequently (in 71%) detected in HER2/neu overexpressing breast cancer than in luminal A (41%), luminal B (39%) and triple-negative tumors (40%). Hematogenous metastasis did not depend on the morphological structure of carcinoma infiltrative component, the state of tumor stroma as well as the proliferative activity in all the investigated groups. Conclusion: The revealed clinicopathological characteristics of different molecular subtypes of invasive breast cancer allow to predict the possible outcome of the disease and select personalized treatment strategy for patients more reasonably. This work was supported by the Russian Foundation for Basic Research (project No. 15–34–20864 and 16–34–00415). en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes Article published earlier |
| spellingShingle | Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes Zavyalova, M. Vtorushin, S. Telegina, N. Krakhmal, N. Savelieva, O. Tashireva, L. Bragina, O. Denisov, E. Kaigorodova, E. Slonimskaya, E. Choynzonov, E. Perelmuter, V. Original contributions |
| title | Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes |
| title_full | Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes |
| title_fullStr | Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes |
| title_full_unstemmed | Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes |
| title_short | Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes |
| title_sort | clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/137996 |
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