Effect of copulation on potentially precancerous prostate lesions, serum testosterone and prolactin levels in rats
The prostate is an exocrine reproductive gland that participates in ejaculation and it is prone to diseases, including cancer. Aim: In the present study, we assessed the longterm effects of copulation on the development of precancerous lesions in rats, and compared them with testosteroneinduced pr...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2016 |
| Автори: | , , , , , , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2016
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/137999 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Effect of copulation on potentially precancerous prostate lesions, serum testosterone and prolactin levels in rats / D. Herrera-Covarrubias, M.B. Tecamachaltzi-Silvaran, M. Barradas-Moctezuma, J.B. Rosales-Raya, J. Manzo, L.I. García, G.E. Aranda-Abreu, N. Ismail, G.A. Coria-Avila, M.E. Hernández // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 73–79. — Бібліогр.: 40 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
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Herrera-Covarrubias, D. Tecamachaltzi-Silvaran, M.B. Barradas-Moctezuma, M. Rosales-Raya, J.B. Manzo, J. García, L.I. Aranda-Abreu, G.E. Ismail, N. Coria-Avila, G.A. Hernández, M.E. 2018-06-17T20:40:38Z 2018-06-17T20:40:38Z 2016 Effect of copulation on potentially precancerous prostate lesions, serum testosterone and prolactin levels in rats / D. Herrera-Covarrubias, M.B. Tecamachaltzi-Silvaran, M. Barradas-Moctezuma, J.B. Rosales-Raya, J. Manzo, L.I. García, G.E. Aranda-Abreu, N. Ismail, G.A. Coria-Avila, M.E. Hernández // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 73–79. — Бібліогр.: 40 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/137999 The prostate is an exocrine reproductive gland that participates in ejaculation and it is prone to diseases, including cancer. Aim: In the present study, we assessed the longterm effects of copulation on the development of precancerous lesions in rats, and compared them with testosteroneinduced prostatic lesions. Materials and Methods: One group of Wistar males was given 10 copulatory sessions to one ejaculation with ovariectomized, hormoneprimed females. Sessions occurred twice per week for a total of ten trials. A second group was exposed to females during the same trials, but physical contact was prevented. In addition, each group received a subcutaneous implant in the back either filled with testosterone propionate (T, 100 mg/kg) or empty. This resulted in four subgroups: 1) Control + No sex, 2) Control + Sex, 3) T + No sex and 4) T + Sex. Two days after the 10th trial all the males were sacrificed for prostate histo logy (H&E) and hormone analysis (testosterone and prolactin). Results: Males from the group Control + No sex expressed normal histo logy. However, those in the groups Control + Sex and T + No sex expressed metaplasia and dysplasia in both the dorsolateral and ventral portions of the prostate, respectively. Interestingly, males from the group T + Sex expressed dysplasia in the dorsolateral prostate only, but not in the ventral prostate. Conclusions: These results indicate that constant copulation may facilitate the development of prostatic lesions in males with normal levels of testosterone. However, copulation induces less lesions in the ventral prostate of males treated with testosterone. This study was supported by Consejo Nacional de Ciencia y Tecnología (CONACYT) from Mexico, with a postdoctoral fellowship to DHC (No. 250561), and to GACA (No. CB-167773). The authors want to give special thanks to Rodrigo Ramírez-Rodríguez for helping with animals and samples handling. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Effect of copulation on potentially precancerous prostate lesions, serum testosterone and prolactin levels in rats Article published earlier |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Effect of copulation on potentially precancerous prostate lesions, serum testosterone and prolactin levels in rats |
| spellingShingle |
Effect of copulation on potentially precancerous prostate lesions, serum testosterone and prolactin levels in rats Herrera-Covarrubias, D. Tecamachaltzi-Silvaran, M.B. Barradas-Moctezuma, M. Rosales-Raya, J.B. Manzo, J. García, L.I. Aranda-Abreu, G.E. Ismail, N. Coria-Avila, G.A. Hernández, M.E. Original contributions |
| title_short |
Effect of copulation on potentially precancerous prostate lesions, serum testosterone and prolactin levels in rats |
| title_full |
Effect of copulation on potentially precancerous prostate lesions, serum testosterone and prolactin levels in rats |
| title_fullStr |
Effect of copulation on potentially precancerous prostate lesions, serum testosterone and prolactin levels in rats |
| title_full_unstemmed |
Effect of copulation on potentially precancerous prostate lesions, serum testosterone and prolactin levels in rats |
| title_sort |
effect of copulation on potentially precancerous prostate lesions, serum testosterone and prolactin levels in rats |
| author |
Herrera-Covarrubias, D. Tecamachaltzi-Silvaran, M.B. Barradas-Moctezuma, M. Rosales-Raya, J.B. Manzo, J. García, L.I. Aranda-Abreu, G.E. Ismail, N. Coria-Avila, G.A. Hernández, M.E. |
| author_facet |
Herrera-Covarrubias, D. Tecamachaltzi-Silvaran, M.B. Barradas-Moctezuma, M. Rosales-Raya, J.B. Manzo, J. García, L.I. Aranda-Abreu, G.E. Ismail, N. Coria-Avila, G.A. Hernández, M.E. |
| topic |
Original contributions |
| topic_facet |
Original contributions |
| publishDate |
2016 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
The prostate is an exocrine reproductive gland that participates in ejaculation and it is prone to diseases, including cancer. Aim: In the present study, we assessed the longterm effects of copulation on the development of precancerous lesions in rats, and compared them with testosteroneinduced prostatic lesions. Materials and Methods: One group of Wistar males was given 10 copulatory sessions to one ejaculation with ovariectomized, hormoneprimed females. Sessions occurred twice per week for a total of ten trials. A second group was exposed to females during the same trials, but physical contact was prevented. In addition, each group received a subcutaneous implant in the back either filled with testosterone propionate (T, 100 mg/kg) or empty. This resulted in four subgroups: 1) Control + No sex, 2) Control + Sex, 3) T + No sex and 4) T + Sex. Two days after the 10th trial all the males were sacrificed for prostate histo logy (H&E) and hormone analysis (testosterone and prolactin). Results: Males from the group Control + No sex expressed normal histo logy. However, those in the groups Control + Sex and T + No sex expressed metaplasia and dysplasia in both the dorsolateral and ventral portions of the prostate, respectively. Interestingly, males from the group T + Sex expressed dysplasia in the dorsolateral prostate only, but not in the ventral prostate. Conclusions: These results indicate that constant copulation may facilitate the development of prostatic lesions in males with normal levels of testosterone. However, copulation induces less lesions in the ventral prostate of males treated with testosterone.
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| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/137999 |
| citation_txt |
Effect of copulation on potentially precancerous prostate lesions, serum testosterone and prolactin levels in rats / D. Herrera-Covarrubias, M.B. Tecamachaltzi-Silvaran, M. Barradas-Moctezuma, J.B. Rosales-Raya, J. Manzo, L.I. García, G.E. Aranda-Abreu, N. Ismail, G.A. Coria-Avila, M.E. Hernández // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 73–79. — Бібліогр.: 40 назв. — англ. |
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2025-12-07T20:24:08Z |
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2025-12-07T20:24:08Z |
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