The effect of gadodiamide on cancer cell lines
Aim: Recent literature suggests that some human cancer cell lines possess a calcium cation receptor. Human myeloma cell lines have demonstrated stimulated cell proliferation by the gadolinium cation through this receptor, and osteosarcoma cell lines possess the same cation receptor. Although enhance...
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2009 |
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | Englisch |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Online Zugang: | https://nasplib.isofts.kiev.ua/handle/123456789/138133 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | The effect of gadodiamide on cancer cell lines / T. Fujimoto, M. Finnegan // Experimental Oncology. — 2009. — Т. 31, № 3. — С. 185-187. — Бібліогр.: 13 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862680158539874304 |
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| author | Fujimoto, T. Finnegan, M. |
| author_facet | Fujimoto, T. Finnegan, M. |
| citation_txt | The effect of gadodiamide on cancer cell lines / T. Fujimoto, M. Finnegan // Experimental Oncology. — 2009. — Т. 31, № 3. — С. 185-187. — Бібліогр.: 13 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: Recent literature suggests that some human cancer cell lines possess a calcium cation receptor. Human myeloma cell lines have demonstrated stimulated cell proliferation by the gadolinium cation through this receptor, and osteosarcoma cell lines possess the same cation receptor. Although enhanced MRI is a very useful diagnostic tool for the treatment of sarcoma in the orthopedic area, incorporating the use of MRI contrast agents based on gadolinium raises the possibility of the stimulation of cancer cell growth. Methods: Human myeloma (RPMI 8226), osteosarcoma (Saos-2) and rat osteosarcoma (UMR-106) cell lines were exposed to various concentrations of common MRI contrast agent gadodiamide (Omniscan®) (5 μM, 50 μM, 500 μM, 5 mM, 50 mM) in a culture medium. The response of the cells was then assessed by measuring cell proliferation and DNA synthesis. Results: Treatment with 5 μM to 5 mM gadodiamide did not stimulate cell proliferation; only cells exposed to 50 mM gadodiamide showed suppressed proliferation rates. Conclusions: Since intravenously injected gadodiamide is diluted from 500 μM to 1 mM by patient blood flow at enhanced MRI examinations, the results of the present study suggest that gadodiamide has not effect on these types of cancer cells.
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| first_indexed | 2025-12-07T15:46:09Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-138133 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T15:46:09Z |
| publishDate | 2009 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Fujimoto, T. Finnegan, M. 2018-06-18T09:33:05Z 2018-06-18T09:33:05Z 2009 The effect of gadodiamide on cancer cell lines / T. Fujimoto, M. Finnegan // Experimental Oncology. — 2009. — Т. 31, № 3. — С. 185-187. — Бібліогр.: 13 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138133 Aim: Recent literature suggests that some human cancer cell lines possess a calcium cation receptor. Human myeloma cell lines have demonstrated stimulated cell proliferation by the gadolinium cation through this receptor, and osteosarcoma cell lines possess the same cation receptor. Although enhanced MRI is a very useful diagnostic tool for the treatment of sarcoma in the orthopedic area, incorporating the use of MRI contrast agents based on gadolinium raises the possibility of the stimulation of cancer cell growth. Methods: Human myeloma (RPMI 8226), osteosarcoma (Saos-2) and rat osteosarcoma (UMR-106) cell lines were exposed to various concentrations of common MRI contrast agent gadodiamide (Omniscan®) (5 μM, 50 μM, 500 μM, 5 mM, 50 mM) in a culture medium. The response of the cells was then assessed by measuring cell proliferation and DNA synthesis. Results: Treatment with 5 μM to 5 mM gadodiamide did not stimulate cell proliferation; only cells exposed to 50 mM gadodiamide showed suppressed proliferation rates. Conclusions: Since intravenously injected gadodiamide is diluted from 500 μM to 1 mM by patient blood flow at enhanced MRI examinations, the results of the present study suggest that gadodiamide has not effect on these types of cancer cells. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Short communications The effect of gadodiamide on cancer cell lines Article published earlier |
| spellingShingle | The effect of gadodiamide on cancer cell lines Fujimoto, T. Finnegan, M. Short communications |
| title | The effect of gadodiamide on cancer cell lines |
| title_full | The effect of gadodiamide on cancer cell lines |
| title_fullStr | The effect of gadodiamide on cancer cell lines |
| title_full_unstemmed | The effect of gadodiamide on cancer cell lines |
| title_short | The effect of gadodiamide on cancer cell lines |
| title_sort | effect of gadodiamide on cancer cell lines |
| topic | Short communications |
| topic_facet | Short communications |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/138133 |
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