The effect of gadodiamide on cancer cell lines

The effect of gadodiamide on cancer cell lines

Aim: Recent literature suggests that some human cancer cell lines possess a calcium cation receptor. Human myeloma cell lines have demonstrated stimulated cell proliferation by the gadolinium cation through this receptor, and osteosarcoma cell lines possess the same cation receptor. Although enhance...

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Published in:Experimental Oncology
Date:2009
Main Authors: Fujimoto, T., Finnegan, M.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
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Short communications
Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/138133
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:The effect of gadodiamide on cancer cell lines / T. Fujimoto, M. Finnegan // Experimental Oncology. — 2009. — Т. 31, № 3. — С. 185-187. — Бібліогр.: 13 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-138133
record_format dspace
spelling Fujimoto, T.
Finnegan, M.
2018-06-18T09:33:05Z
2018-06-18T09:33:05Z
2009
The effect of gadodiamide on cancer cell lines / T. Fujimoto, M. Finnegan // Experimental Oncology. — 2009. — Т. 31, № 3. — С. 185-187. — Бібліогр.: 13 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/138133
Aim: Recent literature suggests that some human cancer cell lines possess a calcium cation receptor. Human myeloma cell lines have demonstrated stimulated cell proliferation by the gadolinium cation through this receptor, and osteosarcoma cell lines possess the same cation receptor. Although enhanced MRI is a very useful diagnostic tool for the treatment of sarcoma in the orthopedic area, incorporating the use of MRI contrast agents based on gadolinium raises the possibility of the stimulation of cancer cell growth. Methods: Human myeloma (RPMI 8226), osteosarcoma (Saos-2) and rat osteosarcoma (UMR-106) cell lines were exposed to various concentrations of common MRI contrast agent gadodiamide (Omniscan®) (5 μM, 50 μM, 500 μM, 5 mM, 50 mM) in a culture medium. The response of the cells was then assessed by measuring cell proliferation and DNA synthesis. Results: Treatment with 5 μM to 5 mM gadodiamide did not stimulate cell proliferation; only cells exposed to 50 mM gadodiamide showed suppressed proliferation rates. Conclusions: Since intravenously injected gadodiamide is diluted from 500 μM to 1 mM by patient blood flow at enhanced MRI examinations, the results of the present study suggest that gadodiamide has not effect on these types of cancer cells.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Short communications
The effect of gadodiamide on cancer cell lines
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title The effect of gadodiamide on cancer cell lines
spellingShingle The effect of gadodiamide on cancer cell lines
Fujimoto, T.
Finnegan, M.
Short communications
title_short The effect of gadodiamide on cancer cell lines
title_full The effect of gadodiamide on cancer cell lines
title_fullStr The effect of gadodiamide on cancer cell lines
title_full_unstemmed The effect of gadodiamide on cancer cell lines
title_sort effect of gadodiamide on cancer cell lines
author Fujimoto, T.
Finnegan, M.
author_facet Fujimoto, T.
Finnegan, M.
topic Short communications
topic_facet Short communications
publishDate 2009
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: Recent literature suggests that some human cancer cell lines possess a calcium cation receptor. Human myeloma cell lines have demonstrated stimulated cell proliferation by the gadolinium cation through this receptor, and osteosarcoma cell lines possess the same cation receptor. Although enhanced MRI is a very useful diagnostic tool for the treatment of sarcoma in the orthopedic area, incorporating the use of MRI contrast agents based on gadolinium raises the possibility of the stimulation of cancer cell growth. Methods: Human myeloma (RPMI 8226), osteosarcoma (Saos-2) and rat osteosarcoma (UMR-106) cell lines were exposed to various concentrations of common MRI contrast agent gadodiamide (Omniscan®) (5 μM, 50 μM, 500 μM, 5 mM, 50 mM) in a culture medium. The response of the cells was then assessed by measuring cell proliferation and DNA synthesis. Results: Treatment with 5 μM to 5 mM gadodiamide did not stimulate cell proliferation; only cells exposed to 50 mM gadodiamide showed suppressed proliferation rates. Conclusions: Since intravenously injected gadodiamide is diluted from 500 μM to 1 mM by patient blood flow at enhanced MRI examinations, the results of the present study suggest that gadodiamide has not effect on these types of cancer cells.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/138133
citation_txt The effect of gadodiamide on cancer cell lines / T. Fujimoto, M. Finnegan // Experimental Oncology. — 2009. — Т. 31, № 3. — С. 185-187. — Бібліогр.: 13 назв. — англ.
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first_indexed 2025-12-07T15:46:09Z
last_indexed 2025-12-07T15:46:09Z
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