The prognostic value of cytogenetic markers for early diagnosis of colorectal cancer
To investigate the spectrum of chromosome changes in colorectal adenomas and adenocarcinomas and to evaluate the prognostic significance of the chromosome rearrangements. Methods: The study was carried out using the cytogenetic analysis of biopsy specimens (n = 56) of single and multiply adenomas (f...
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2009 |
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| Format: | Artikel |
| Sprache: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | The prognostic value of cytogenetic markers for early diagnosis of colorectal cancer / M. Lozynska // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 237-241. — Бібліогр.: 19 назв. — англ. |
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Lozynska, M. 2018-06-18T09:42:31Z 2018-06-18T09:42:31Z 2009 The prognostic value of cytogenetic markers for early diagnosis of colorectal cancer / M. Lozynska // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 237-241. — Бібліогр.: 19 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138138 To investigate the spectrum of chromosome changes in colorectal adenomas and adenocarcinomas and to evaluate the prognostic significance of the chromosome rearrangements. Methods: The study was carried out using the cytogenetic analysis of biopsy specimens (n = 56) of single and multiply adenomas (familial adenomatous syndromes; n = 38) and adenocarcinomas (n = 18). Results: The karyotype of adenomas was normal in the majority of cases, but some adenomas with severe dysplasia of epithelium carry the quantitative chromosome abnormalities and structural rearrangements. The combination of additional copies of chromosomes 13, 18, 20 in adenomas points on an unfavorable prognosis. The chromosome abnormalities were found in 100% of adenocarcinomas biopsy specimens. Conclusions: The transition from colorectal adenomas to adenocarcinomas is accompanied by elevation of chromosome abnormalities level, in particular, by increased clonal variety, selective accumulation of the copies of chromosomes 2, 3, 20, 16, with simultaneous monosomy of chromosomes 17, 18, 8, 6, 14, and del 1p. Author thanks Dr. Yuriy Lozynskyy, M.D. (Danylo Halytsky National Medical University) for his helpful assistance, and Dr. Andrzej Plawski (Institute of Human Genetics of Polish Academy of Sciences, Poznan, Poland) for the detection of the mutation in APC gene in patients with FAP. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions The prognostic value of cytogenetic markers for early diagnosis of colorectal cancer Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
The prognostic value of cytogenetic markers for early diagnosis of colorectal cancer |
| spellingShingle |
The prognostic value of cytogenetic markers for early diagnosis of colorectal cancer Lozynska, M. Original contributions |
| title_short |
The prognostic value of cytogenetic markers for early diagnosis of colorectal cancer |
| title_full |
The prognostic value of cytogenetic markers for early diagnosis of colorectal cancer |
| title_fullStr |
The prognostic value of cytogenetic markers for early diagnosis of colorectal cancer |
| title_full_unstemmed |
The prognostic value of cytogenetic markers for early diagnosis of colorectal cancer |
| title_sort |
prognostic value of cytogenetic markers for early diagnosis of colorectal cancer |
| author |
Lozynska, M. |
| author_facet |
Lozynska, M. |
| topic |
Original contributions |
| topic_facet |
Original contributions |
| publishDate |
2009 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
To investigate the spectrum of chromosome changes in colorectal adenomas and adenocarcinomas and to evaluate the prognostic significance of the chromosome rearrangements. Methods: The study was carried out using the cytogenetic analysis of biopsy specimens (n = 56) of single and multiply adenomas (familial adenomatous syndromes; n = 38) and adenocarcinomas (n = 18). Results: The karyotype of adenomas was normal in the majority of cases, but some adenomas with severe dysplasia of epithelium carry the quantitative chromosome abnormalities and structural rearrangements. The combination of additional copies of chromosomes 13, 18, 20 in adenomas points on an unfavorable prognosis. The chromosome abnormalities were found in 100% of adenocarcinomas biopsy specimens. Conclusions: The transition from colorectal adenomas to adenocarcinomas is accompanied by elevation of chromosome abnormalities level, in particular, by increased clonal variety, selective accumulation of the copies of chromosomes 2, 3, 20, 16, with simultaneous monosomy of chromosomes 17, 18, 8, 6, 14, and del 1p.
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| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/138138 |
| citation_txt |
The prognostic value of cytogenetic markers for early diagnosis of colorectal cancer / M. Lozynska // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 237-241. — Бібліогр.: 19 назв. — англ. |
| work_keys_str_mv |
AT lozynskam theprognosticvalueofcytogeneticmarkersforearlydiagnosisofcolorectalcancer AT lozynskam prognosticvalueofcytogeneticmarkersforearlydiagnosisofcolorectalcancer |
| first_indexed |
2025-12-07T19:54:32Z |
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2025-12-07T19:54:32Z |
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1850880580572413952 |