Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma
To study antitumor and antimetastatic activities of antitumor vaccine (ATV) prepared from cisplatin (CP) sensitive and resistant strains of Lewis lung carcinoma (LLC). Methods: The inhibition of tumor growth, and the mean survival time of the tumor-bearing animals, the number and the volume of metas...
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| Published in: | Experimental Oncology |
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| Date: | 2009 |
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/138140 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma / G.P. Potebnya, I.M. Voeykova, G.S. Lisovenko, N.L. Cheremshenko, I.M. Todor, O.Yu. Yudina, O.V. Kovtonyuk, V.F. Chekhun // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 226-230. — Бібліогр.: 36 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862613486235811840 |
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| author | Potebnya, G.P. Voeykova, I.M. Lisovenko, G.S. Cheremshenko, N.L. Todor, I.M. Yudina, O.Yu. Kovtonyuk, O.V. Chekhun, V.F. |
| author_facet | Potebnya, G.P. Voeykova, I.M. Lisovenko, G.S. Cheremshenko, N.L. Todor, I.M. Yudina, O.Yu. Kovtonyuk, O.V. Chekhun, V.F. |
| citation_txt | Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma / G.P. Potebnya, I.M. Voeykova, G.S. Lisovenko, N.L. Cheremshenko, I.M. Todor, O.Yu. Yudina, O.V. Kovtonyuk, V.F. Chekhun // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 226-230. — Бібліогр.: 36 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | To study antitumor and antimetastatic activities of antitumor vaccine (ATV) prepared from cisplatin (CP) sensitive and resistant strains of Lewis lung carcinoma (LLC). Methods: The inhibition of tumor growth, and the mean survival time of the tumor-bearing animals, the number and the volume of metastases were measured as the indices of ATV efficacy. The activity of cytotoxic T-lymphocytes and natural killer cells, peritoneal macrophages (Mph), the level of tumor necrosis factor and the total proteolytic activity of blood plasma (PA) were assessed. Results: ATV from CP resistant LLC prepared using cytolectin (CL) of В. subtilis В-7025 significantly inhibited growth of CP resistant tumors (by 52%) and increased mean survival time (MST) of animals (by 44.6%). The index of metastasis inhibition for ATV prepared from CP sensitive or resistant LLC was 154.5% and 227.0%, respectively. In all vaccine-treated animals, Mph activity was shown to be significantly increased. In spite of high antitumor and antimetastatic effects of ATV prepared from CP resistant LLC, PA in plasma of animals inoculated with CP resistant LLC was increased significantly upon vaccine administration.
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| first_indexed | 2025-11-29T07:12:51Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-138140 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-29T07:12:51Z |
| publishDate | 2009 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Potebnya, G.P. Voeykova, I.M. Lisovenko, G.S. Cheremshenko, N.L. Todor, I.M. Yudina, O.Yu. Kovtonyuk, O.V. Chekhun, V.F. 2018-06-18T09:44:42Z 2018-06-18T09:44:42Z 2009 Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma / G.P. Potebnya, I.M. Voeykova, G.S. Lisovenko, N.L. Cheremshenko, I.M. Todor, O.Yu. Yudina, O.V. Kovtonyuk, V.F. Chekhun // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 226-230. — Бібліогр.: 36 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138140 To study antitumor and antimetastatic activities of antitumor vaccine (ATV) prepared from cisplatin (CP) sensitive and resistant strains of Lewis lung carcinoma (LLC). Methods: The inhibition of tumor growth, and the mean survival time of the tumor-bearing animals, the number and the volume of metastases were measured as the indices of ATV efficacy. The activity of cytotoxic T-lymphocytes and natural killer cells, peritoneal macrophages (Mph), the level of tumor necrosis factor and the total proteolytic activity of blood plasma (PA) were assessed. Results: ATV from CP resistant LLC prepared using cytolectin (CL) of В. subtilis В-7025 significantly inhibited growth of CP resistant tumors (by 52%) and increased mean survival time (MST) of animals (by 44.6%). The index of metastasis inhibition for ATV prepared from CP sensitive or resistant LLC was 154.5% and 227.0%, respectively. In all vaccine-treated animals, Mph activity was shown to be significantly increased. In spite of high antitumor and antimetastatic effects of ATV prepared from CP resistant LLC, PA in plasma of animals inoculated with CP resistant LLC was increased significantly upon vaccine administration. The study was performed within the frames of the project “Peculiarities of oncogenome functioning” (№ 0102U003228) with the financial support of target scientific program of NAS of Ukraine “Physiologicalbiochemical and molecular-genetic basis of live systems functioning and development of principles of their control”. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma Article published earlier |
| spellingShingle | Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma Potebnya, G.P. Voeykova, I.M. Lisovenko, G.S. Cheremshenko, N.L. Todor, I.M. Yudina, O.Yu. Kovtonyuk, O.V. Chekhun, V.F. Original contributions |
| title | Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma |
| title_full | Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma |
| title_fullStr | Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma |
| title_full_unstemmed | Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma |
| title_short | Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma |
| title_sort | antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/138140 |
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