The effect of racemic gossypol and AT-101 on angiogenic profile of OVCAR-3 cells: a preliminary molecular framework for gossypol enantiomers

• Published in: Experimental Oncology
• Date: 2009
• Main Authors: Varol, U., Karaca, B., Tunali, D., Degirmenci, M., Cirak, Y., Purcu, D.U., Uzunoglu, S., Sezgin, C., Karabulut, B., Sanli, U.A., Uslu, R.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/138141
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: The effect of racemic gossypol and AT-101 on angiogenic profile of OVCAR-3 cells: a preliminary molecular framework for gossypol enantiomers / U. Varol, B. Karaca, D. Tunali, M. Degirmenci, Y. Cirak, D.U. Purcu, S. Uzunolgu, C. Sezgin, B. Karabulut, U.A. Sanli, R. Uslu // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 220-225. — Бібліогр.: 34 назв. — англ.

To compare the effect of racemic gossypol with its (–)/(–) enantiomer (AT-101) on expression profiles of angiogenic molecules by mRNA levels in human ovarian cancer cell line OVCAR-3. Methods: Cell viability assay (2,3-bis (2-methoxy-4-nitro-5- sulfophenyl)-5-[(phenylamino) carbonyl]-2H-tetrazolium...