Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action

Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action

Aim: To analyze the correlation between the elevated sensitivity of drug resistant breast cancer cells to the action of lymphokine-activated lymphocytes (LAK) and expression of E-cadherin and other marker proteins by cancer cells and lymphocytes. Methods: Breast tumor explants were cultured with aut...

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Бібліографічні деталі
Опубліковано в: :Experimental Oncology
Дата:2009
Автори: Berezhnaya, N.M., Belova, O.B., Vinnichuk, Yu.D., Tarutinov, V.I.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
Теми:
Original contributions
Онлайн доступ:https://nasplib.isofts.kiev.ua/handle/123456789/138143
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action / N.M. Berezhnaya, O.B. Belova, Yu.D. Vinnichuk, V.I. Tarutinov // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 242-245. — Бібліогр.: 28 назв. — англ.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-138143
record_format dspace
spelling Berezhnaya, N.M.
Belova, O.B.
Vinnichuk, Yu.D.
Tarutinov, V.I.
2018-06-18T09:48:03Z
2018-06-18T09:48:03Z
2009
Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action / N.M. Berezhnaya, O.B. Belova, Yu.D. Vinnichuk, V.I. Tarutinov // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 242-245. — Бібліогр.: 28 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/138143
Aim: To analyze the correlation between the elevated sensitivity of drug resistant breast cancer cells to the action of lymphokine-activated lymphocytes (LAK) and expression of E-cadherin and other marker proteins by cancer cells and lymphocytes. Methods: Breast tumor explants were cultured with autologous lymphocytes in double diffusion chambers. The results were evaluated by morphological criteria of explants growth. Expression level of proteins on tumor cells was analyzed using immunohistochemical method on paraffin embedded sections, and by indirect immunofluorescence — on lymphocytes. Results: Significant decrease of E-cadherin expression and significant increase of nuclear antigen of proliferating cells expression have been detected on drug resistant malignant human breast tumor (DRHBT) cells compared with drug sensitive breast tumor (DSHBT) cells. Autologous LAK possessed the highest antitumor activity against DRHBT cells that was associated with high expression level of soybean lectin receptor. Conclusion: Malignant drug resistant tumors are characterized by reverse relation between E-cadherin expression level and their proliferative activity. Marked antitumor action of LAK against these tumors is associated with high expression level of soybean lectin receptor on the lymphocytes.
We thank L.Yu. Kovaleva for collaboration, and N.Yu. Lukyanova for valuable advices.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action
spellingShingle Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action
Berezhnaya, N.M.
Belova, O.B.
Vinnichuk, Yu.D.
Tarutinov, V.I.
Original contributions
title_short Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action
title_full Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action
title_fullStr Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action
title_full_unstemmed Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action
title_sort expression of e-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action
author Berezhnaya, N.M.
Belova, O.B.
Vinnichuk, Yu.D.
Tarutinov, V.I.
author_facet Berezhnaya, N.M.
Belova, O.B.
Vinnichuk, Yu.D.
Tarutinov, V.I.
topic Original contributions
topic_facet Original contributions
publishDate 2009
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: To analyze the correlation between the elevated sensitivity of drug resistant breast cancer cells to the action of lymphokine-activated lymphocytes (LAK) and expression of E-cadherin and other marker proteins by cancer cells and lymphocytes. Methods: Breast tumor explants were cultured with autologous lymphocytes in double diffusion chambers. The results were evaluated by morphological criteria of explants growth. Expression level of proteins on tumor cells was analyzed using immunohistochemical method on paraffin embedded sections, and by indirect immunofluorescence — on lymphocytes. Results: Significant decrease of E-cadherin expression and significant increase of nuclear antigen of proliferating cells expression have been detected on drug resistant malignant human breast tumor (DRHBT) cells compared with drug sensitive breast tumor (DSHBT) cells. Autologous LAK possessed the highest antitumor activity against DRHBT cells that was associated with high expression level of soybean lectin receptor. Conclusion: Malignant drug resistant tumors are characterized by reverse relation between E-cadherin expression level and their proliferative activity. Marked antitumor action of LAK against these tumors is associated with high expression level of soybean lectin receptor on the lymphocytes.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/138143
citation_txt Expression of E-cadherin in drug resistant human breast cancer cells and their sensitivity to lymphokine-activated lymphocytes action / N.M. Berezhnaya, O.B. Belova, Yu.D. Vinnichuk, V.I. Tarutinov // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 242-245. — Бібліогр.: 28 назв. — англ.
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AT vinnichukyud expressionofecadherinindrugresistanthumanbreastcancercellsandtheirsensitivitytolymphokineactivatedlymphocytesaction
AT tarutinovvi expressionofecadherinindrugresistanthumanbreastcancercellsandtheirsensitivitytolymphokineactivatedlymphocytesaction
first_indexed 2025-12-07T19:33:32Z
last_indexed 2025-12-07T19:33:32Z
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