The role of ultraviolet radiation and tyrosine stimulated melanogenesis in the induction of oxidative stress alterations in fair skin melanocytes

• Published in: Experimental Oncology
• Date: 2009
• Main Authors: Baldea, I., Mocan, T., Cosgarea, R.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2009
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/138205
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: The role of ultraviolet radiation and tyrosine stimulated melanogenesis in the induction of oxidative stress alterations in fair skin melanocytes / I. Baldea, T. Mocan, R. Cosgarea // Experimental Oncology. — 2009. — Т. 31, № 4. — С. 200-208. — Бібліогр.: 53 назв. — англ.

Melanocytes are producing melanin after UV irradiation as a defense mechanism. However, UV-induced damage is involved in melanoma initiation, depending on skin phototype. Melanocytes seem to be extremely susceptible to free radicals. Their main enzymatic antioxidants are superoxide dismutase and cat...