Comparison of various tissue and cell therapy approaches when restoring ovarian, hepatic and kidney’s function after chemotherapy-induced ovarian failure
About 1% of women suffer from premature ovarian failure, which leads to a significant deterioration in the life quality. Most often this condition is caused by performed chemotherapy, autoimmune diseases, surgery performed on ovaries, uterus, or fallopian tubes. The aim of this study was to compare...
Saved in:
| Published in: | Experimental Oncology |
|---|---|
| Date: | 2017 |
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2017
|
| Subjects: | |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/138536 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Comparison of various tissue and cell therapy approaches when restoring ovarian, hepatic and kidney’s function after chemotherapy-induced ovarian failure / M.M. Kozub, V.Y. Prokopiuk, K.P. Skibina, O.V. Prokopiuk, N.I. Kozub // Experimental Oncology. — 2017 — Т. 39, № 3. — С. 181–185. — Бібліогр.: 24 назв. — англ. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862545024977207296 |
|---|---|
| author | Kozub, M.M. Prokopiuk, V.Y. Skibina, K.P. Prokopiuk, O.V. Kozub, N.I. |
| author_facet | Kozub, M.M. Prokopiuk, V.Y. Skibina, K.P. Prokopiuk, O.V. Kozub, N.I. |
| citation_txt | Comparison of various tissue and cell therapy approaches when restoring ovarian, hepatic and kidney’s function after chemotherapy-induced ovarian failure / M.M. Kozub, V.Y. Prokopiuk, K.P. Skibina, O.V. Prokopiuk, N.I. Kozub // Experimental Oncology. — 2017 — Т. 39, № 3. — С. 181–185. — Бібліогр.: 24 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | About 1% of women suffer from premature ovarian failure, which leads to a significant deterioration in the life quality. Most often this condition is caused by performed chemotherapy, autoimmune diseases, surgery performed on ovaries, uterus, or fallopian tubes. The aim of this study was to compare different approaches of tissue and cell therapy in restoring the sexual function in case of ovarian failure induced by chemotherapy. Materials and Methods: The study was carried out in BALB/c mice with the modeled ovarian failure, induced by cyclophosphamide and busulfan. The restoration dynamics of ovarian and sexual function, liver and kidneys after application of cryopreserved explants, cryoextract, placental mesenchymal stem cells, those of adipose tissue has been studied. Results: It has been shown that the use of various methods of cell and tissue therapy has comparable efficacy when treating an ovarian failure induced by chemotherapy. The most rapid and complete restoration of the reproductive system, liver and kidneys was observed when using the placental explants, extract and cells, but not with the use of mesenchymal stem cells of adipose tissue. No recovery of fertility in this experiment was observed. Conclusion: Various methods of cellular and tissue therapy are perspective in treatment of the chemotherapy complications. More effective are placental derivates.
|
| first_indexed | 2025-11-25T01:38:27Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-138536 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-25T01:38:27Z |
| publishDate | 2017 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Kozub, M.M. Prokopiuk, V.Y. Skibina, K.P. Prokopiuk, O.V. Kozub, N.I. 2018-06-19T09:08:02Z 2018-06-19T09:08:02Z 2017 Comparison of various tissue and cell therapy approaches when restoring ovarian, hepatic and kidney’s function after chemotherapy-induced ovarian failure / M.M. Kozub, V.Y. Prokopiuk, K.P. Skibina, O.V. Prokopiuk, N.I. Kozub // Experimental Oncology. — 2017 — Т. 39, № 3. — С. 181–185. — Бібліогр.: 24 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138536 About 1% of women suffer from premature ovarian failure, which leads to a significant deterioration in the life quality. Most often this condition is caused by performed chemotherapy, autoimmune diseases, surgery performed on ovaries, uterus, or fallopian tubes. The aim of this study was to compare different approaches of tissue and cell therapy in restoring the sexual function in case of ovarian failure induced by chemotherapy. Materials and Methods: The study was carried out in BALB/c mice with the modeled ovarian failure, induced by cyclophosphamide and busulfan. The restoration dynamics of ovarian and sexual function, liver and kidneys after application of cryopreserved explants, cryoextract, placental mesenchymal stem cells, those of adipose tissue has been studied. Results: It has been shown that the use of various methods of cell and tissue therapy has comparable efficacy when treating an ovarian failure induced by chemotherapy. The most rapid and complete restoration of the reproductive system, liver and kidneys was observed when using the placental explants, extract and cells, but not with the use of mesenchymal stem cells of adipose tissue. No recovery of fertility in this experiment was observed. Conclusion: Various methods of cellular and tissue therapy are perspective in treatment of the chemotherapy complications. More effective are placental derivates. The authors are grateful to the employees of the Medical University of Hannover, Germany (Hannover Medical School, Germany) Dr. Thomas Mueller, Dr. Denys Pogozhykh, Dr. Olena Pogozhykh for assistance in performing the research (advisory assistance when working with placental MSCs) en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Comparison of various tissue and cell therapy approaches when restoring ovarian, hepatic and kidney’s function after chemotherapy-induced ovarian failure Article published earlier |
| spellingShingle | Comparison of various tissue and cell therapy approaches when restoring ovarian, hepatic and kidney’s function after chemotherapy-induced ovarian failure Kozub, M.M. Prokopiuk, V.Y. Skibina, K.P. Prokopiuk, O.V. Kozub, N.I. Original contributions |
| title | Comparison of various tissue and cell therapy approaches when restoring ovarian, hepatic and kidney’s function after chemotherapy-induced ovarian failure |
| title_full | Comparison of various tissue and cell therapy approaches when restoring ovarian, hepatic and kidney’s function after chemotherapy-induced ovarian failure |
| title_fullStr | Comparison of various tissue and cell therapy approaches when restoring ovarian, hepatic and kidney’s function after chemotherapy-induced ovarian failure |
| title_full_unstemmed | Comparison of various tissue and cell therapy approaches when restoring ovarian, hepatic and kidney’s function after chemotherapy-induced ovarian failure |
| title_short | Comparison of various tissue and cell therapy approaches when restoring ovarian, hepatic and kidney’s function after chemotherapy-induced ovarian failure |
| title_sort | comparison of various tissue and cell therapy approaches when restoring ovarian, hepatic and kidney’s function after chemotherapy-induced ovarian failure |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/138536 |
| work_keys_str_mv | AT kozubmm comparisonofvarioustissueandcelltherapyapproacheswhenrestoringovarianhepaticandkidneysfunctionafterchemotherapyinducedovarianfailure AT prokopiukvy comparisonofvarioustissueandcelltherapyapproacheswhenrestoringovarianhepaticandkidneysfunctionafterchemotherapyinducedovarianfailure AT skibinakp comparisonofvarioustissueandcelltherapyapproacheswhenrestoringovarianhepaticandkidneysfunctionafterchemotherapyinducedovarianfailure AT prokopiukov comparisonofvarioustissueandcelltherapyapproacheswhenrestoringovarianhepaticandkidneysfunctionafterchemotherapyinducedovarianfailure AT kozubni comparisonofvarioustissueandcelltherapyapproacheswhenrestoringovarianhepaticandkidneysfunctionafterchemotherapyinducedovarianfailure |