Autogeneic RNA-electroporated CD40-ligand activated B-cells from hepatocellular carcinoma patients induce CD8+ T-cell responses ex vivo

• Published in: Experimental Oncology
• Date: 2007
• Main Authors: Shen, S., Xu, Z., Qian, X., Ding, Y., Yu, L., Liu, B.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2007
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/138573
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Autogeneic RNA-electroporated CD40-ligand activated B-cells from hepatocellular carcinoma patients induce CD8+ T-cell responses ex vivo / S. Shen, Z. Xu, X. Qian, Y. Ding, L. Yu, B. Liu // Experimental Oncology. — 2007. — Т. 29, № 2. — С. 137-143. — Бібліогр.: 49 назв. — англ.

Since dendritic cells (DCs) constitute only 0.1–0.5% of human peripheral blood mononuclear cells (PBMCs), and generation of DCs from monocytes or stem cells is difficult and expensive, we choose B-lymphocytes as an alternative, cost-effective source of antigen presenting cells (APC). Aim: To induce...