Biodistribution analysis of cisplatin in liposomal form in animals with cisplatinresistant and cisplatin-sensitive carcinoma

Biodistribution analysis of cisplatin in liposomal form in animals with cisplatinresistant and cisplatin-sensitive carcinoma

Aim: To analyze the relation between pharmacokinetics of cisplatin in liposomal form and antitumor efficacy toward cisplatinresistant and cisplatin-sensitive variants of Guerin carcinoma. Concentration of platinum was measured by atomic absorption spectrophotometry (С115М1 “Selmi”, Ukraine). Elimina...

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Опубліковано в: :Experimental Oncology
Дата:2010
Автори: Nosko, M.M., Pivnyuk, V.M., Solyanik, G.I., Kulik, G.I., Todor, I.N., Momot, V.Ya., Melnikov, O.R., Ponomareva, O.V., Chekhun, V.F.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2010
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Original contributions
Онлайн доступ:https://nasplib.isofts.kiev.ua/handle/123456789/138591
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Biodistribution analysis of cisplatin in liposomal form in animals with cisplatinresistant and cisplatin-sensitive carcinoma / M.M. Nosko, V.M. Pivnyuk, G.I. Solyanik, G.I. Kulik, I.N. Todor, V.Ya. Momot, O.R. Melnikov, O.V. Ponomareva, V.F. Chekhun // Experimental Oncology. — 2010. — Т. 32, № 1. — С. 40-43. — Бібліогр.: 14 назв. — англ.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-138591
record_format dspace
spelling Nosko, M.M.
Pivnyuk, V.M.
Solyanik, G.I.
Kulik, G.I.
Todor, I.N.
Momot, V.Ya.
Melnikov, O.R.
Ponomareva, O.V.
Chekhun, V.F.
2018-06-19T10:12:30Z
2018-06-19T10:12:30Z
2010
Biodistribution analysis of cisplatin in liposomal form in animals with cisplatinresistant and cisplatin-sensitive carcinoma / M.M. Nosko, V.M. Pivnyuk, G.I. Solyanik, G.I. Kulik, I.N. Todor, V.Ya. Momot, O.R. Melnikov, O.V. Ponomareva, V.F. Chekhun // Experimental Oncology. — 2010. — Т. 32, № 1. — С. 40-43. — Бібліогр.: 14 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/138591
Aim: To analyze the relation between pharmacokinetics of cisplatin in liposomal form and antitumor efficacy toward cisplatinresistant and cisplatin-sensitive variants of Guerin carcinoma. Concentration of platinum was measured by atomic absorption spectrophotometry (С115М1 “Selmi”, Ukraine). Elimination constant was calculated based on the dynamics of cisplatin concentration in time period between 1 h to 24 h using nonlinear regression analysis. Area under curve (AUC24) was calculated by the trapezium method. Results: It was shown that for liposomal form of cisplatin (LCp) AUC24 in tumor practically didn’t depend on the level of the tumor sensitivity, while in animals with the resistant variant (CpRGC), AUC24 for free cisplatin (FCp) decreased by 70% less (p < 0.001) as compared to the sensitive tumor strain (CpSGC). Significant decrease of elimination constant of LCp compared to FCp in blood serum of rats bearing either CpRGC or CpSGC tumors favors cisplatin accumulation in tumor tissues with low vascularization level. The dynamics of cisplatin concentration in CpRGC variant was characterized by 90% higher level in 24 h after administration of LCp as compared to FCp (p < 0.05). This fact may explain increased antitumor efficacy of LCp compared to FCp toward CpRGC variant. In the study of kidney function, AUC24 index for LCp was by 68.6% (p < 0.01) and 50.7% (p < 0.05) lower than AUC24 index for FCp in rats with CpRGC and CpSGC variants, respectively. No significant differences have been found in biodistribution of cisplatin in both pharmaceutical forms in liver and lung in CpRGC-r CpSGC-bearing rats. Conclusion: The results suggest that cisplatin in liposomal form possesses higher specificity of antitumor action than free cisplatin.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Biodistribution analysis of cisplatin in liposomal form in animals with cisplatinresistant and cisplatin-sensitive carcinoma
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Biodistribution analysis of cisplatin in liposomal form in animals with cisplatinresistant and cisplatin-sensitive carcinoma
spellingShingle Biodistribution analysis of cisplatin in liposomal form in animals with cisplatinresistant and cisplatin-sensitive carcinoma
Nosko, M.M.
Pivnyuk, V.M.
Solyanik, G.I.
Kulik, G.I.
Todor, I.N.
Momot, V.Ya.
Melnikov, O.R.
Ponomareva, O.V.
Chekhun, V.F.
Original contributions
title_short Biodistribution analysis of cisplatin in liposomal form in animals with cisplatinresistant and cisplatin-sensitive carcinoma
title_full Biodistribution analysis of cisplatin in liposomal form in animals with cisplatinresistant and cisplatin-sensitive carcinoma
title_fullStr Biodistribution analysis of cisplatin in liposomal form in animals with cisplatinresistant and cisplatin-sensitive carcinoma
title_full_unstemmed Biodistribution analysis of cisplatin in liposomal form in animals with cisplatinresistant and cisplatin-sensitive carcinoma
title_sort biodistribution analysis of cisplatin in liposomal form in animals with cisplatinresistant and cisplatin-sensitive carcinoma
author Nosko, M.M.
Pivnyuk, V.M.
Solyanik, G.I.
Kulik, G.I.
Todor, I.N.
Momot, V.Ya.
Melnikov, O.R.
Ponomareva, O.V.
Chekhun, V.F.
author_facet Nosko, M.M.
Pivnyuk, V.M.
Solyanik, G.I.
Kulik, G.I.
Todor, I.N.
Momot, V.Ya.
Melnikov, O.R.
Ponomareva, O.V.
Chekhun, V.F.
topic Original contributions
topic_facet Original contributions
publishDate 2010
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: To analyze the relation between pharmacokinetics of cisplatin in liposomal form and antitumor efficacy toward cisplatinresistant and cisplatin-sensitive variants of Guerin carcinoma. Concentration of platinum was measured by atomic absorption spectrophotometry (С115М1 “Selmi”, Ukraine). Elimination constant was calculated based on the dynamics of cisplatin concentration in time period between 1 h to 24 h using nonlinear regression analysis. Area under curve (AUC24) was calculated by the trapezium method. Results: It was shown that for liposomal form of cisplatin (LCp) AUC24 in tumor practically didn’t depend on the level of the tumor sensitivity, while in animals with the resistant variant (CpRGC), AUC24 for free cisplatin (FCp) decreased by 70% less (p < 0.001) as compared to the sensitive tumor strain (CpSGC). Significant decrease of elimination constant of LCp compared to FCp in blood serum of rats bearing either CpRGC or CpSGC tumors favors cisplatin accumulation in tumor tissues with low vascularization level. The dynamics of cisplatin concentration in CpRGC variant was characterized by 90% higher level in 24 h after administration of LCp as compared to FCp (p < 0.05). This fact may explain increased antitumor efficacy of LCp compared to FCp toward CpRGC variant. In the study of kidney function, AUC24 index for LCp was by 68.6% (p < 0.01) and 50.7% (p < 0.05) lower than AUC24 index for FCp in rats with CpRGC and CpSGC variants, respectively. No significant differences have been found in biodistribution of cisplatin in both pharmaceutical forms in liver and lung in CpRGC-r CpSGC-bearing rats. Conclusion: The results suggest that cisplatin in liposomal form possesses higher specificity of antitumor action than free cisplatin.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/138591
citation_txt Biodistribution analysis of cisplatin in liposomal form in animals with cisplatinresistant and cisplatin-sensitive carcinoma / M.M. Nosko, V.M. Pivnyuk, G.I. Solyanik, G.I. Kulik, I.N. Todor, V.Ya. Momot, O.R. Melnikov, O.V. Ponomareva, V.F. Chekhun // Experimental Oncology. — 2010. — Т. 32, № 1. — С. 40-43. — Бібліогр.: 14 назв. — англ.
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first_indexed 2025-12-07T20:27:57Z
last_indexed 2025-12-07T20:27:57Z
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