Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes
Aim: To estimate the viability of normal and transformed T-lymphocytes after UV/Vis irradiation in the presence of pristine fullerenes C60. Methods: Thymocytes were isolated from Wistar rats’ thymus. Murine leukemia L1210 and human lymphoma Jurkat cells were used in this study. Mercury-vapor lamp wa...
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| Published in: | Experimental Oncology |
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| Date: | 2010 |
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2010
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/138592 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes / S.V. Prylutska, I.I. Grynyuk, K.O. Palyvoda, O.P. Matyshevska // Experimental Oncology. — 2010. — Т. 32, № 1. — С. 29-32. — Бібліогр.: 15 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862641055361400832 |
|---|---|
| author | Prylutska, S.V. Grynyuk, I.I. Palyvoda, K.O. Matyshevska, O.P. |
| author_facet | Prylutska, S.V. Grynyuk, I.I. Palyvoda, K.O. Matyshevska, O.P. |
| citation_txt | Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes / S.V. Prylutska, I.I. Grynyuk, K.O. Palyvoda, O.P. Matyshevska // Experimental Oncology. — 2010. — Т. 32, № 1. — С. 29-32. — Бібліогр.: 15 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: To estimate the viability of normal and transformed T-lymphocytes after UV/Vis irradiation in the presence of pristine fullerenes C60. Methods: Thymocytes were isolated from Wistar rats’ thymus. Murine leukemia L1210 and human lymphoma Jurkat cells were used in this study. Mercury-vapor lamp was used for fullerenes C60 photoexcitation. Cytotoxicity was etermined by MTT assay. Changes in cell morphology were monitored by phase-contrast light microscopy. Results: fullerenes C60 exhibit cytotoxic effect against transformed T-lymphocytes when combined with UV/Vis irradiation (320–600 nm). Photoinduced effect was enhanced with the increasing of irradiation time period and C60 concentration, cell death was registered after 24 hours incubation. Fullerenes C60 photocytotoxicity against normal T-lymphocytes (thymocytes) was not observed. Conclusion: The present study suggests that pristine fullerenes C60 have the potential to be an effective photosensitizer and exhibit cytotoxic effect on transformed T-cells in vitro.
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| first_indexed | 2025-12-01T04:09:25Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-138592 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-01T04:09:25Z |
| publishDate | 2010 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Prylutska, S.V. Grynyuk, I.I. Palyvoda, K.O. Matyshevska, O.P. 2018-06-19T10:13:26Z 2018-06-19T10:13:26Z 2010 Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes / S.V. Prylutska, I.I. Grynyuk, K.O. Palyvoda, O.P. Matyshevska // Experimental Oncology. — 2010. — Т. 32, № 1. — С. 29-32. — Бібліогр.: 15 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138592 Aim: To estimate the viability of normal and transformed T-lymphocytes after UV/Vis irradiation in the presence of pristine fullerenes C60. Methods: Thymocytes were isolated from Wistar rats’ thymus. Murine leukemia L1210 and human lymphoma Jurkat cells were used in this study. Mercury-vapor lamp was used for fullerenes C60 photoexcitation. Cytotoxicity was etermined by MTT assay. Changes in cell morphology were monitored by phase-contrast light microscopy. Results: fullerenes C60 exhibit cytotoxic effect against transformed T-lymphocytes when combined with UV/Vis irradiation (320–600 nm). Photoinduced effect was enhanced with the increasing of irradiation time period and C60 concentration, cell death was registered after 24 hours incubation. Fullerenes C60 photocytotoxicity against normal T-lymphocytes (thymocytes) was not observed. Conclusion: The present study suggests that pristine fullerenes C60 have the potential to be an effective photosensitizer and exhibit cytotoxic effect on transformed T-cells in vitro. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes Article published earlier |
| spellingShingle | Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes Prylutska, S.V. Grynyuk, I.I. Palyvoda, K.O. Matyshevska, O.P. Original contributions |
| title | Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes |
| title_full | Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes |
| title_fullStr | Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes |
| title_full_unstemmed | Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes |
| title_short | Photoinduced cytotoxic effect of fullerenes C60 on transformed T-lymphocytes |
| title_sort | photoinduced cytotoxic effect of fullerenes c60 on transformed t-lymphocytes |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/138592 |
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