No significant association between the promoter region polymorphisms of factor VII gene and risk of venous thrombosis in cancer patients
Factor VII (FVII) plays an important role in blood coagulation. The role of common polymorphisms influencing the FVII plasma levels in thromboembolic disorders has been evaluated but there is no published data related to the effect of FVII gene polymorphisms on the venous thrombosis risk in cancer....
Збережено в:
| Опубліковано в: : | Experimental Oncology |
|---|---|
| Дата: | 2010 |
| Автори: | , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2010
|
| Теми: | |
| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/138595 |
| Теги: |
Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | No significant association between the promoter region polymorphisms of factor VII gene and risk of venous thrombosis in cancer patients / A. Eroglu, A. Ozturk, R. Cam, N. Akar // Experimental Oncology. — 2010. — Т. 32, № 1. — С. 15-18. — Бібліогр.: 22 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862560015547629568 |
|---|---|
| author | Eroglu, A. Ozturk, A. Cam, R. Akar, N. |
| author_facet | Eroglu, A. Ozturk, A. Cam, R. Akar, N. |
| citation_txt | No significant association between the promoter region polymorphisms of factor VII gene and risk of venous thrombosis in cancer patients / A. Eroglu, A. Ozturk, R. Cam, N. Akar // Experimental Oncology. — 2010. — Т. 32, № 1. — С. 15-18. — Бібліогр.: 22 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Factor VII (FVII) plays an important role in blood coagulation. The role of common polymorphisms influencing the FVII plasma levels in thromboembolic disorders has been evaluated but there is no published data related to the effect of FVII gene polymorphisms on the venous thrombosis risk in cancer. Aim: To investigate the association of three common functional polymorphisms in the promoter region of FVII gene: a decanucleotide insertion at position-323 (-323ins10-bp), a G to T substitution at position-401 (-401GT), and a G to A substitution at position-402 (-401GT) with venous thrombosis in cancer patients. Materials and Methods: The study included 60 cancer patients with venous thromboembolism (VTE) (group 1) and 130 cancer patients without VTE (group 2). Genotyping of -323ins10-bp, -401GT, and -402GA polymorphisms in the promoter region of FVII gene was performed by the method of single-strand conformation polymorphism analysis and sequencing. Factor V Leiden (FVL) was also determined in all cases. Results: The frequency of FVL was significantly greater in cancer patients with VTE compared with group 2 patients (p < 0.0001). For each polymorphism of FVII gene, the distributions of genotypes and allele frequencies were not significantly different between two groups of patients (p > 0.05). The results did not change significantly after the exclusion of patients carrying the FVL (p > 0.05). Conclusions: The screening for the -323ins10-bp, -401GT, and -402GA olymorphisms of FVII gene did not contribute to a meaningful diagnostic nvestigation in cancer patients with venous thrombosis.
|
| first_indexed | 2025-11-25T22:54:41Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-138595 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-25T22:54:41Z |
| publishDate | 2010 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Eroglu, A. Ozturk, A. Cam, R. Akar, N. 2018-06-19T10:15:51Z 2018-06-19T10:15:51Z 2010 No significant association between the promoter region polymorphisms of factor VII gene and risk of venous thrombosis in cancer patients / A. Eroglu, A. Ozturk, R. Cam, N. Akar // Experimental Oncology. — 2010. — Т. 32, № 1. — С. 15-18. — Бібліогр.: 22 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138595 Factor VII (FVII) plays an important role in blood coagulation. The role of common polymorphisms influencing the FVII plasma levels in thromboembolic disorders has been evaluated but there is no published data related to the effect of FVII gene polymorphisms on the venous thrombosis risk in cancer. Aim: To investigate the association of three common functional polymorphisms in the promoter region of FVII gene: a decanucleotide insertion at position-323 (-323ins10-bp), a G to T substitution at position-401 (-401GT), and a G to A substitution at position-402 (-401GT) with venous thrombosis in cancer patients. Materials and Methods: The study included 60 cancer patients with venous thromboembolism (VTE) (group 1) and 130 cancer patients without VTE (group 2). Genotyping of -323ins10-bp, -401GT, and -402GA polymorphisms in the promoter region of FVII gene was performed by the method of single-strand conformation polymorphism analysis and sequencing. Factor V Leiden (FVL) was also determined in all cases. Results: The frequency of FVL was significantly greater in cancer patients with VTE compared with group 2 patients (p < 0.0001). For each polymorphism of FVII gene, the distributions of genotypes and allele frequencies were not significantly different between two groups of patients (p > 0.05). The results did not change significantly after the exclusion of patients carrying the FVL (p > 0.05). Conclusions: The screening for the -323ins10-bp, -401GT, and -402GA olymorphisms of FVII gene did not contribute to a meaningful diagnostic nvestigation in cancer patients with venous thrombosis. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions No significant association between the promoter region polymorphisms of factor VII gene and risk of venous thrombosis in cancer patients Article published earlier |
| spellingShingle | No significant association between the promoter region polymorphisms of factor VII gene and risk of venous thrombosis in cancer patients Eroglu, A. Ozturk, A. Cam, R. Akar, N. Original contributions |
| title | No significant association between the promoter region polymorphisms of factor VII gene and risk of venous thrombosis in cancer patients |
| title_full | No significant association between the promoter region polymorphisms of factor VII gene and risk of venous thrombosis in cancer patients |
| title_fullStr | No significant association between the promoter region polymorphisms of factor VII gene and risk of venous thrombosis in cancer patients |
| title_full_unstemmed | No significant association between the promoter region polymorphisms of factor VII gene and risk of venous thrombosis in cancer patients |
| title_short | No significant association between the promoter region polymorphisms of factor VII gene and risk of venous thrombosis in cancer patients |
| title_sort | no significant association between the promoter region polymorphisms of factor vii gene and risk of venous thrombosis in cancer patients |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/138595 |
| work_keys_str_mv | AT eroglua nosignificantassociationbetweenthepromoterregionpolymorphismsoffactorviigeneandriskofvenousthrombosisincancerpatients AT ozturka nosignificantassociationbetweenthepromoterregionpolymorphismsoffactorviigeneandriskofvenousthrombosisincancerpatients AT camr nosignificantassociationbetweenthepromoterregionpolymorphismsoffactorviigeneandriskofvenousthrombosisincancerpatients AT akarn nosignificantassociationbetweenthepromoterregionpolymorphismsoffactorviigeneandriskofvenousthrombosisincancerpatients |