Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results

Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results

Aim: To create adequate orthotopic model of peritoneal carcinomatosis in rats using a transplantable rat tumor M-1 sarcoma, to assess the early tumor response after intraperitoneal photodynamic and/or antiangiogenic therapy for peritoneal carcinomatosis. Methods: In 14–18 days after intraperitoneal...

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Бібліографічні деталі
Опубліковано в: :Experimental Oncology
Дата:2010
Автори: Piatrouskaya, N.A., Kharuzhyk, S.A., Vozmitel, M.A., Mazurenko, A.N., Istomin, Y.P.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2010
Теми:
Original contributions
Онлайн доступ:https://nasplib.isofts.kiev.ua/handle/123456789/138601
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results / N.A. Piatrouskaya, S.A. Kharuzhyk, M.A. Vozmitel, A.N. Mazurenko, Y.P. Istomin // Experimental Oncology. — 2010. — Т. 32, № 2. — С. 100-103. — Бібліогр.: 14 назв. — англ.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-138601
record_format dspace
spelling Piatrouskaya, N.A.
Kharuzhyk, S.A.
Vozmitel, M.A.
Mazurenko, A.N.
Istomin, Y.P.
2018-06-19T10:22:18Z
2018-06-19T10:22:18Z
2010
Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results / N.A. Piatrouskaya, S.A. Kharuzhyk, M.A. Vozmitel, A.N. Mazurenko, Y.P. Istomin // Experimental Oncology. — 2010. — Т. 32, № 2. — С. 100-103. — Бібліогр.: 14 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/138601
Aim: To create adequate orthotopic model of peritoneal carcinomatosis in rats using a transplantable rat tumor M-1 sarcoma, to assess the early tumor response after intraperitoneal photodynamic and/or antiangiogenic therapy for peritoneal carcinomatosis. Methods: In 14–18 days after intraperitoneal inoculation, eighteen tumor-bearing animals were divided into three groups and undergone intraperitoneal photodynamic therapy and/or antiangiogenic therapy. Assessment of the tumor posttreatment changes was performed using a method of vital staining with Evans blue, MRI-monitoring and morphologic investigation. Results: Percentage of necrosis in disseminated tumors of animals undergone combination therapy significantly higher then after each of the methods alone and achieved 89.46% vs 41.47% after antiangiogenic therapy and 69.73% after photodynamic therapy. Contrast-enhanced MRI showed entirely necrotic tumor nodes in rats undergone the combination therapy. Morphologic study confirmed that tumor response after combination therapy was characterized by maximal spread of necrotic and inflammatory changes in tumor. Conclusion: Preliminary results demonstrate enhance of the treatment outcome after combination of antiangiogenic and intraperitoneal photodynamic therapies for peritoneal carcinomatosis in rats.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
spellingShingle Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
Piatrouskaya, N.A.
Kharuzhyk, S.A.
Vozmitel, M.A.
Mazurenko, A.N.
Istomin, Y.P.
Original contributions
title_short Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
title_full Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
title_fullStr Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
title_full_unstemmed Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
title_sort experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
author Piatrouskaya, N.A.
Kharuzhyk, S.A.
Vozmitel, M.A.
Mazurenko, A.N.
Istomin, Y.P.
author_facet Piatrouskaya, N.A.
Kharuzhyk, S.A.
Vozmitel, M.A.
Mazurenko, A.N.
Istomin, Y.P.
topic Original contributions
topic_facet Original contributions
publishDate 2010
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: To create adequate orthotopic model of peritoneal carcinomatosis in rats using a transplantable rat tumor M-1 sarcoma, to assess the early tumor response after intraperitoneal photodynamic and/or antiangiogenic therapy for peritoneal carcinomatosis. Methods: In 14–18 days after intraperitoneal inoculation, eighteen tumor-bearing animals were divided into three groups and undergone intraperitoneal photodynamic therapy and/or antiangiogenic therapy. Assessment of the tumor posttreatment changes was performed using a method of vital staining with Evans blue, MRI-monitoring and morphologic investigation. Results: Percentage of necrosis in disseminated tumors of animals undergone combination therapy significantly higher then after each of the methods alone and achieved 89.46% vs 41.47% after antiangiogenic therapy and 69.73% after photodynamic therapy. Contrast-enhanced MRI showed entirely necrotic tumor nodes in rats undergone the combination therapy. Morphologic study confirmed that tumor response after combination therapy was characterized by maximal spread of necrotic and inflammatory changes in tumor. Conclusion: Preliminary results demonstrate enhance of the treatment outcome after combination of antiangiogenic and intraperitoneal photodynamic therapies for peritoneal carcinomatosis in rats.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/138601
citation_txt Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results / N.A. Piatrouskaya, S.A. Kharuzhyk, M.A. Vozmitel, A.N. Mazurenko, Y.P. Istomin // Experimental Oncology. — 2010. — Т. 32, № 2. — С. 100-103. — Бібліогр.: 14 назв. — англ.
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AT vozmitelma experimentalstudyofantiangiogenicandphotodynamictherapiescombinationfortreatmentofperitonealcarcinomatosispreliminaryresults
AT mazurenkoan experimentalstudyofantiangiogenicandphotodynamictherapiescombinationfortreatmentofperitonealcarcinomatosispreliminaryresults
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first_indexed 2025-12-07T17:02:04Z
last_indexed 2025-12-07T17:02:04Z
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