Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression

Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression

Aim: To examine the influence of combined genotypes of TP53 (exon 4, intron 3, intron 6) and XRCC1 (codon 10) on lung cancer age of onset. Methods: TP53 polymorphisms in codon 72 of exon 4 (Arg72Pro), in intron 3 (16 bp duplication), in intron 6 (G/A transition) and XRCC1 polymorphism in codon 10 (A...

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Бібліографічні деталі
Опубліковано в: :Experimental Oncology
Дата:2010
Автори: Cherdyntseva, N.V., Gervas, P.A., Litvyakov, N.V., Stakcheeva, M.N., Ponomaryeva, A.A., Dobrodeev, A.Yu., Denisov, E.V., Belyavskaya, V.A., Choinzonov, E.L.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2010
Теми:
Original contributions
Онлайн доступ:https://nasplib.isofts.kiev.ua/handle/123456789/138611
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression / N.V. Cherdyntseva, P.A. Gervas, N.V. Litvyakov, M.N. Stakcheeva, A.A. Ponomaryeva, A.Yu. Dobrodeev, E.V. Denisov, V.A. Belyavskaya, E.L. Choinzonov // Experimental Oncology. — 2010. — Т. 32, № 3. — С. 205-208. — Бібліогр.: 23 назв. — англ.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-138611
record_format dspace
spelling Cherdyntseva, N.V.
Gervas, P.A.
Litvyakov, N.V.
Stakcheeva, M.N.
Ponomaryeva, A.A.
Dobrodeev, A.Yu.
Denisov, E.V.
Belyavskaya, V.A.
Choinzonov, E.L.
2018-06-19T10:33:19Z
2018-06-19T10:33:19Z
2010
Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression / N.V. Cherdyntseva, P.A. Gervas, N.V. Litvyakov, M.N. Stakcheeva, A.A. Ponomaryeva, A.Yu. Dobrodeev, E.V. Denisov, V.A. Belyavskaya, E.L. Choinzonov // Experimental Oncology. — 2010. — Т. 32, № 3. — С. 205-208. — Бібліогр.: 23 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/138611
Aim: To examine the influence of combined genotypes of TP53 (exon 4, intron 3, intron 6) and XRCC1 (codon 10) on lung cancer age of onset. Methods: TP53 polymorphisms in codon 72 of exon 4 (Arg72Pro), in intron 3 (16 bp duplication), in intron 6 (G/A transition) and XRCC1 polymorphism in codon 10 (Arg399Gln) were analyzed in blood cells of 177 lung cancer patients and 196 healthy donors with Restriction Fragment Lenth Polymorphism PCR. Results: We showed that combination of TP53 variant genotypes and XRCC1 variant genotype is associated with the increased lung cancer risk in younger, but not elderly, smokers. In contrast, wild allele combination increases lung cancer risk for individuals over the age of 60. Conclusion: Our data confirm antagonistic pleiotropy hypothesis indicating that p53 protects the organism against cancer early in life, but promoting aging phenotype, including late life cancer in older persons.
The research has been carried out with the support of the grants from Federal Special Purpose Program «Scientific and academic-teaching staff of innovative Russia» # P31 and # P256.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression
spellingShingle Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression
Cherdyntseva, N.V.
Gervas, P.A.
Litvyakov, N.V.
Stakcheeva, M.N.
Ponomaryeva, A.A.
Dobrodeev, A.Yu.
Denisov, E.V.
Belyavskaya, V.A.
Choinzonov, E.L.
Original contributions
title_short Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression
title_full Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression
title_fullStr Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression
title_full_unstemmed Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression
title_sort age-related function of tumor suppressor gene tp53:contribution to cancer risk and progression
author Cherdyntseva, N.V.
Gervas, P.A.
Litvyakov, N.V.
Stakcheeva, M.N.
Ponomaryeva, A.A.
Dobrodeev, A.Yu.
Denisov, E.V.
Belyavskaya, V.A.
Choinzonov, E.L.
author_facet Cherdyntseva, N.V.
Gervas, P.A.
Litvyakov, N.V.
Stakcheeva, M.N.
Ponomaryeva, A.A.
Dobrodeev, A.Yu.
Denisov, E.V.
Belyavskaya, V.A.
Choinzonov, E.L.
topic Original contributions
topic_facet Original contributions
publishDate 2010
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: To examine the influence of combined genotypes of TP53 (exon 4, intron 3, intron 6) and XRCC1 (codon 10) on lung cancer age of onset. Methods: TP53 polymorphisms in codon 72 of exon 4 (Arg72Pro), in intron 3 (16 bp duplication), in intron 6 (G/A transition) and XRCC1 polymorphism in codon 10 (Arg399Gln) were analyzed in blood cells of 177 lung cancer patients and 196 healthy donors with Restriction Fragment Lenth Polymorphism PCR. Results: We showed that combination of TP53 variant genotypes and XRCC1 variant genotype is associated with the increased lung cancer risk in younger, but not elderly, smokers. In contrast, wild allele combination increases lung cancer risk for individuals over the age of 60. Conclusion: Our data confirm antagonistic pleiotropy hypothesis indicating that p53 protects the organism against cancer early in life, but promoting aging phenotype, including late life cancer in older persons.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/138611
citation_txt Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression / N.V. Cherdyntseva, P.A. Gervas, N.V. Litvyakov, M.N. Stakcheeva, A.A. Ponomaryeva, A.Yu. Dobrodeev, E.V. Denisov, V.A. Belyavskaya, E.L. Choinzonov // Experimental Oncology. — 2010. — Т. 32, № 3. — С. 205-208. — Бібліогр.: 23 назв. — англ.
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first_indexed 2025-12-07T19:16:49Z
last_indexed 2025-12-07T19:16:49Z
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