Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression

• Published in: Experimental Oncology
• Date: 2010
• Main Authors: Cherdyntseva, N.V., Gervas, P.A., Litvyakov, N.V., Stakcheeva, M.N., Ponomaryeva, A.A., Dobrodeev, A.Yu., Denisov, E.V., Belyavskaya, V.A., Choinzonov, E.L.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2010
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/138611
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Age-related function of tumor suppressor gene TP53:contribution to cancer risk and progression / N.V. Cherdyntseva, P.A. Gervas, N.V. Litvyakov, M.N. Stakcheeva, A.A. Ponomaryeva, A.Yu. Dobrodeev, E.V. Denisov, V.A. Belyavskaya, E.L. Choinzonov // Experimental Oncology. — 2010. — Т. 32, № 3. — С. 205-208. — Бібліогр.: 23 назв. — англ.

Aim: To examine the influence of combined genotypes of TP53 (exon 4, intron 3, intron 6) and XRCC1 (codon 10) on lung cancer age of onset. Methods: TP53 polymorphisms in codon 72 of exon 4 (Arg72Pro), in intron 3 (16 bp duplication), in intron 6 (G/A transition) and XRCC1 polymorphism in codon 10 (A...