Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line
Aim: To study distribution and accumulation of liposomal form of doxorubicin in human breast cancer cells of MCF-7 line and Dox-resistant subline MCF-7/Dox. Methods: High performance liquid chromatography and laser confocal microscopy were used. Results: It has been shown that conventional form of d...
Збережено в:
| Опубліковано в: : | Experimental Oncology |
|---|---|
| Дата: | 2011 |
| Автори: | , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2011
|
| Теми: | |
| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/138616 |
| Теги: |
Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line / N.V. Rusetskaya, N. Khariton, O.V. Yurchenko, V.F. Chekhun // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 78-82. — Бібліогр.: 22 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
nasplib_isofts_kiev_ua-123456789-138616 |
|---|---|
| record_format |
dspace |
| spelling |
Rusetskaya, N.V. Khariton, N. Yurchenko, O.V. Chekhun, V.F. 2018-06-19T10:40:04Z 2018-06-19T10:40:04Z 2011 Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line / N.V. Rusetskaya, N. Khariton, O.V. Yurchenko, V.F. Chekhun // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 78-82. — Бібліогр.: 22 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138616 Aim: To study distribution and accumulation of liposomal form of doxorubicin in human breast cancer cells of MCF-7 line and Dox-resistant subline MCF-7/Dox. Methods: High performance liquid chromatography and laser confocal microscopy were used. Results: It has been shown that conventional form of doxorubicin was more efficiently delivered to the MCF-7 cells already after 30 min of incubation amounting to its maximum concentration after 4 h. MCF-7/Dox cells are characterized by lower doxorubicin accumulation rate compared with parental cells. The quantity of accumulated liposomal form of doxorubicin is high in MCF-7 cells, and, what is important, Dox-resistant cells accumulated higher levels of liposomal form of doxorubicin than its conventional form. Conclusion: It has been shown that intracellular distribution and accumulation of liposomal forms of doxorubicin in parental and Dox-resistant MCF-7 cells differs from that of conventional doxorubicin. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line |
| spellingShingle |
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line Rusetskaya, N.V. Khariton, N. Yurchenko, O.V. Chekhun, V.F. Original contributions |
| title_short |
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line |
| title_full |
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line |
| title_fullStr |
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line |
| title_full_unstemmed |
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line |
| title_sort |
distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of mcf-7 line |
| author |
Rusetskaya, N.V. Khariton, N. Yurchenko, O.V. Chekhun, V.F. |
| author_facet |
Rusetskaya, N.V. Khariton, N. Yurchenko, O.V. Chekhun, V.F. |
| topic |
Original contributions |
| topic_facet |
Original contributions |
| publishDate |
2011 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Aim: To study distribution and accumulation of liposomal form of doxorubicin in human breast cancer cells of MCF-7 line and Dox-resistant subline MCF-7/Dox. Methods: High performance liquid chromatography and laser confocal microscopy were used. Results: It has been shown that conventional form of doxorubicin was more efficiently delivered to the MCF-7 cells already after 30 min of incubation amounting to its maximum concentration after 4 h. MCF-7/Dox cells are characterized by lower doxorubicin accumulation rate compared with parental cells. The quantity of accumulated liposomal form of doxorubicin is high in MCF-7 cells, and, what is important, Dox-resistant cells accumulated higher levels of liposomal form of doxorubicin than its conventional form. Conclusion: It has been shown that intracellular distribution and accumulation of liposomal forms of doxorubicin in parental and Dox-resistant MCF-7 cells differs from that of conventional doxorubicin.
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/138616 |
| citation_txt |
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line / N.V. Rusetskaya, N. Khariton, O.V. Yurchenko, V.F. Chekhun // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 78-82. — Бібліогр.: 22 назв. — англ. |
| work_keys_str_mv |
AT rusetskayanv distributionandaccumulationofliposomalformofdoxorubicininbreastcancercellsofmcf7line AT kharitonn distributionandaccumulationofliposomalformofdoxorubicininbreastcancercellsofmcf7line AT yurchenkoov distributionandaccumulationofliposomalformofdoxorubicininbreastcancercellsofmcf7line AT chekhunvf distributionandaccumulationofliposomalformofdoxorubicininbreastcancercellsofmcf7line |
| first_indexed |
2025-12-07T18:18:30Z |
| last_indexed |
2025-12-07T18:18:30Z |
| _version_ |
1850874538770825216 |