Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line
Aim: To study distribution and accumulation of liposomal form of doxorubicin in human breast cancer cells of MCF-7 line and Dox-resistant subline MCF-7/Dox. Methods: High performance liquid chromatography and laser confocal microscopy were used. Results: It has been shown that conventional form of d...
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| Published in: | Experimental Oncology |
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| Date: | 2011 |
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2011
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/138616 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line / N.V. Rusetskaya, N. Khariton, O.V. Yurchenko, V.F. Chekhun // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 78-82. — Бібліогр.: 22 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862718990566031360 |
|---|---|
| author | Rusetskaya, N.V. Khariton, N. Yurchenko, O.V. Chekhun, V.F. |
| author_facet | Rusetskaya, N.V. Khariton, N. Yurchenko, O.V. Chekhun, V.F. |
| citation_txt | Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line / N.V. Rusetskaya, N. Khariton, O.V. Yurchenko, V.F. Chekhun // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 78-82. — Бібліогр.: 22 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: To study distribution and accumulation of liposomal form of doxorubicin in human breast cancer cells of MCF-7 line and Dox-resistant subline MCF-7/Dox. Methods: High performance liquid chromatography and laser confocal microscopy were used. Results: It has been shown that conventional form of doxorubicin was more efficiently delivered to the MCF-7 cells already after 30 min of incubation amounting to its maximum concentration after 4 h. MCF-7/Dox cells are characterized by lower doxorubicin accumulation rate compared with parental cells. The quantity of accumulated liposomal form of doxorubicin is high in MCF-7 cells, and, what is important, Dox-resistant cells accumulated higher levels of liposomal form of doxorubicin than its conventional form. Conclusion: It has been shown that intracellular distribution and accumulation of liposomal forms of doxorubicin in parental and Dox-resistant MCF-7 cells differs from that of conventional doxorubicin.
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| first_indexed | 2025-12-07T18:18:30Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-138616 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T18:18:30Z |
| publishDate | 2011 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Rusetskaya, N.V. Khariton, N. Yurchenko, O.V. Chekhun, V.F. 2018-06-19T10:40:04Z 2018-06-19T10:40:04Z 2011 Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line / N.V. Rusetskaya, N. Khariton, O.V. Yurchenko, V.F. Chekhun // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 78-82. — Бібліогр.: 22 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138616 Aim: To study distribution and accumulation of liposomal form of doxorubicin in human breast cancer cells of MCF-7 line and Dox-resistant subline MCF-7/Dox. Methods: High performance liquid chromatography and laser confocal microscopy were used. Results: It has been shown that conventional form of doxorubicin was more efficiently delivered to the MCF-7 cells already after 30 min of incubation amounting to its maximum concentration after 4 h. MCF-7/Dox cells are characterized by lower doxorubicin accumulation rate compared with parental cells. The quantity of accumulated liposomal form of doxorubicin is high in MCF-7 cells, and, what is important, Dox-resistant cells accumulated higher levels of liposomal form of doxorubicin than its conventional form. Conclusion: It has been shown that intracellular distribution and accumulation of liposomal forms of doxorubicin in parental and Dox-resistant MCF-7 cells differs from that of conventional doxorubicin. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line Article published earlier |
| spellingShingle | Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line Rusetskaya, N.V. Khariton, N. Yurchenko, O.V. Chekhun, V.F. Original contributions |
| title | Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line |
| title_full | Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line |
| title_fullStr | Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line |
| title_full_unstemmed | Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line |
| title_short | Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line |
| title_sort | distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of mcf-7 line |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/138616 |
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