Quantitative analysis of SLC34A2 expression in different types of ovarian tumors

Quantitative analysis of SLC34A2 expression in different types of ovarian tumors

Aim: The main purpose of this study was to estimate the SLC34A2 gene expression in normal ovary and different types of ovarian tumors. Methods: We have investigated SLC34A2 gene expression level in papillary serous, endometrioid, unspecified adenocarcinomas, benign tumors, and normal ovarian tissues...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Experimental Oncology
Datum:2011
Hauptverfasser: Shyian, M., Gryshkova, V., Kostianets, O., Gorshkov, V., Goloev, Yu., Goncharuk, I., Nespryadko, S., Vorobjova, L., Filonenko, V., Kiyamova, R.
Format: Artikel
Sprache:English
Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2011
Schlagworte:
Original contributions
Online Zugang:https://nasplib.isofts.kiev.ua/handle/123456789/138632
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Zitieren:Quantitative analysis of SLC34A2 expression in different types of ovarian tumors / M. Shyian, V. Gryshkova, O. Kostianets, V. Gorshkov, Yu. Goloev, I. Goncharuk, S. Nespryadko, L. Vorobjova, V. Filonenko, R. Kiyamova // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 94-98. — Бібліогр.: 32 назв. — англ.

Institution

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-138632
record_format dspace
spelling Shyian, M.
Gryshkova, V.
Kostianets, O.
Gorshkov, V.
Goloev, Yu.
Goncharuk, I.
Nespryadko, S.
Vorobjova, L.
Filonenko, V.
Kiyamova, R.
2018-06-19T10:45:54Z
2018-06-19T10:45:54Z
2011
Quantitative analysis of SLC34A2 expression in different types of ovarian tumors / M. Shyian, V. Gryshkova, O. Kostianets, V. Gorshkov, Yu. Goloev, I. Goncharuk, S. Nespryadko, L. Vorobjova, V. Filonenko, R. Kiyamova // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 94-98. — Бібліогр.: 32 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/138632
Aim: The main purpose of this study was to estimate the SLC34A2 gene expression in normal ovary and different types of ovarian tumors. Methods: We have investigated SLC34A2 gene expression level in papillary serous, endometrioid, unspecified adenocarcinomas, benign tumors, and normal ovarian tissues using real-time PCR analysis. Differences in gene expression were calculated as fold changes in gene expression in ovarian carcinomas and benign tumors compared to normal ovary. Results: We have found that SLC34A2 gene was highly expressed in well-differentiated endometrioid and papillary serous ovarian carcinomas compared to low-differentiated endometrioid carcinomas, benign serous cystoadenomas and normal ovary. Analysis of SLC34A2 gene expression according to tumor differentiation level (poor- and well-differentiated) showed that SLC34A2 is up-regulated in well differentiated tumors. Conclusion: Upregulation of SLC34A2 gene expression in well-differentiated tumors may reflect cell differentiation processes during ovarian cancerogenesis and could serve as potential marker for ovarian cancer diagnosis and prognosis.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Quantitative analysis of SLC34A2 expression in different types of ovarian tumors
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Quantitative analysis of SLC34A2 expression in different types of ovarian tumors
spellingShingle Quantitative analysis of SLC34A2 expression in different types of ovarian tumors
Shyian, M.
Gryshkova, V.
Kostianets, O.
Gorshkov, V.
Goloev, Yu.
Goncharuk, I.
Nespryadko, S.
Vorobjova, L.
Filonenko, V.
Kiyamova, R.
Original contributions
title_short Quantitative analysis of SLC34A2 expression in different types of ovarian tumors
title_full Quantitative analysis of SLC34A2 expression in different types of ovarian tumors
title_fullStr Quantitative analysis of SLC34A2 expression in different types of ovarian tumors
title_full_unstemmed Quantitative analysis of SLC34A2 expression in different types of ovarian tumors
title_sort quantitative analysis of slc34a2 expression in different types of ovarian tumors
author Shyian, M.
Gryshkova, V.
Kostianets, O.
Gorshkov, V.
Goloev, Yu.
Goncharuk, I.
Nespryadko, S.
Vorobjova, L.
Filonenko, V.
Kiyamova, R.
author_facet Shyian, M.
Gryshkova, V.
Kostianets, O.
Gorshkov, V.
Goloev, Yu.
Goncharuk, I.
Nespryadko, S.
Vorobjova, L.
Filonenko, V.
Kiyamova, R.
topic Original contributions
topic_facet Original contributions
publishDate 2011
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: The main purpose of this study was to estimate the SLC34A2 gene expression in normal ovary and different types of ovarian tumors. Methods: We have investigated SLC34A2 gene expression level in papillary serous, endometrioid, unspecified adenocarcinomas, benign tumors, and normal ovarian tissues using real-time PCR analysis. Differences in gene expression were calculated as fold changes in gene expression in ovarian carcinomas and benign tumors compared to normal ovary. Results: We have found that SLC34A2 gene was highly expressed in well-differentiated endometrioid and papillary serous ovarian carcinomas compared to low-differentiated endometrioid carcinomas, benign serous cystoadenomas and normal ovary. Analysis of SLC34A2 gene expression according to tumor differentiation level (poor- and well-differentiated) showed that SLC34A2 is up-regulated in well differentiated tumors. Conclusion: Upregulation of SLC34A2 gene expression in well-differentiated tumors may reflect cell differentiation processes during ovarian cancerogenesis and could serve as potential marker for ovarian cancer diagnosis and prognosis.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/138632
citation_txt Quantitative analysis of SLC34A2 expression in different types of ovarian tumors / M. Shyian, V. Gryshkova, O. Kostianets, V. Gorshkov, Yu. Goloev, I. Goncharuk, S. Nespryadko, L. Vorobjova, V. Filonenko, R. Kiyamova // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 94-98. — Бібліогр.: 32 назв. — англ.
work_keys_str_mv AT shyianm quantitativeanalysisofslc34a2expressionindifferenttypesofovariantumors
AT gryshkovav quantitativeanalysisofslc34a2expressionindifferenttypesofovariantumors
AT kostianetso quantitativeanalysisofslc34a2expressionindifferenttypesofovariantumors
AT gorshkovv quantitativeanalysisofslc34a2expressionindifferenttypesofovariantumors
AT goloevyu quantitativeanalysisofslc34a2expressionindifferenttypesofovariantumors
AT goncharuki quantitativeanalysisofslc34a2expressionindifferenttypesofovariantumors
AT nespryadkos quantitativeanalysisofslc34a2expressionindifferenttypesofovariantumors
AT vorobjoval quantitativeanalysisofslc34a2expressionindifferenttypesofovariantumors
AT filonenkov quantitativeanalysisofslc34a2expressionindifferenttypesofovariantumors
AT kiyamovar quantitativeanalysisofslc34a2expressionindifferenttypesofovariantumors
first_indexed 2025-11-28T07:41:17Z
last_indexed 2025-11-28T07:41:17Z
_version_ 1850853485252182016

Ähnliche Einträge