Quantitative analysis of SLC34A2 expression in different types of ovarian tumors
Aim: The main purpose of this study was to estimate the SLC34A2 gene expression in normal ovary and different types of ovarian tumors. Methods: We have investigated SLC34A2 gene expression level in papillary serous, endometrioid, unspecified adenocarcinomas, benign tumors, and normal ovarian tissues...
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| Published in: | Experimental Oncology |
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| Date: | 2011 |
| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2011
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/138632 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Quantitative analysis of SLC34A2 expression in different types of ovarian tumors / M. Shyian, V. Gryshkova, O. Kostianets, V. Gorshkov, Yu. Goloev, I. Goncharuk, S. Nespryadko, L. Vorobjova, V. Filonenko, R. Kiyamova // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 94-98. — Бібліогр.: 32 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862604466268667904 |
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| author | Shyian, M. Gryshkova, V. Kostianets, O. Gorshkov, V. Goloev, Yu. Goncharuk, I. Nespryadko, S. Vorobjova, L. Filonenko, V. Kiyamova, R. |
| author_facet | Shyian, M. Gryshkova, V. Kostianets, O. Gorshkov, V. Goloev, Yu. Goncharuk, I. Nespryadko, S. Vorobjova, L. Filonenko, V. Kiyamova, R. |
| citation_txt | Quantitative analysis of SLC34A2 expression in different types of ovarian tumors / M. Shyian, V. Gryshkova, O. Kostianets, V. Gorshkov, Yu. Goloev, I. Goncharuk, S. Nespryadko, L. Vorobjova, V. Filonenko, R. Kiyamova // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 94-98. — Бібліогр.: 32 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: The main purpose of this study was to estimate the SLC34A2 gene expression in normal ovary and different types of ovarian tumors. Methods: We have investigated SLC34A2 gene expression level in papillary serous, endometrioid, unspecified adenocarcinomas, benign tumors, and normal ovarian tissues using real-time PCR analysis. Differences in gene expression were calculated as fold changes in gene expression in ovarian carcinomas and benign tumors compared to normal ovary. Results: We have found that SLC34A2 gene was highly expressed in well-differentiated endometrioid and papillary serous ovarian carcinomas compared to low-differentiated endometrioid carcinomas, benign serous cystoadenomas and normal ovary. Analysis of SLC34A2 gene expression according to tumor differentiation level (poor- and well-differentiated) showed that SLC34A2 is up-regulated in well differentiated tumors. Conclusion: Upregulation of SLC34A2 gene expression in well-differentiated tumors may reflect cell differentiation processes during ovarian cancerogenesis and could serve as potential marker for ovarian cancer diagnosis and prognosis.
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| first_indexed | 2025-11-28T07:41:17Z |
| format | Article |
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| id | nasplib_isofts_kiev_ua-123456789-138632 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-28T07:41:17Z |
| publishDate | 2011 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Shyian, M. Gryshkova, V. Kostianets, O. Gorshkov, V. Goloev, Yu. Goncharuk, I. Nespryadko, S. Vorobjova, L. Filonenko, V. Kiyamova, R. 2018-06-19T10:45:54Z 2018-06-19T10:45:54Z 2011 Quantitative analysis of SLC34A2 expression in different types of ovarian tumors / M. Shyian, V. Gryshkova, O. Kostianets, V. Gorshkov, Yu. Goloev, I. Goncharuk, S. Nespryadko, L. Vorobjova, V. Filonenko, R. Kiyamova // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 94-98. — Бібліогр.: 32 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138632 Aim: The main purpose of this study was to estimate the SLC34A2 gene expression in normal ovary and different types of ovarian tumors. Methods: We have investigated SLC34A2 gene expression level in papillary serous, endometrioid, unspecified adenocarcinomas, benign tumors, and normal ovarian tissues using real-time PCR analysis. Differences in gene expression were calculated as fold changes in gene expression in ovarian carcinomas and benign tumors compared to normal ovary. Results: We have found that SLC34A2 gene was highly expressed in well-differentiated endometrioid and papillary serous ovarian carcinomas compared to low-differentiated endometrioid carcinomas, benign serous cystoadenomas and normal ovary. Analysis of SLC34A2 gene expression according to tumor differentiation level (poor- and well-differentiated) showed that SLC34A2 is up-regulated in well differentiated tumors. Conclusion: Upregulation of SLC34A2 gene expression in well-differentiated tumors may reflect cell differentiation processes during ovarian cancerogenesis and could serve as potential marker for ovarian cancer diagnosis and prognosis. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Quantitative analysis of SLC34A2 expression in different types of ovarian tumors Article published earlier |
| spellingShingle | Quantitative analysis of SLC34A2 expression in different types of ovarian tumors Shyian, M. Gryshkova, V. Kostianets, O. Gorshkov, V. Goloev, Yu. Goncharuk, I. Nespryadko, S. Vorobjova, L. Filonenko, V. Kiyamova, R. Original contributions |
| title | Quantitative analysis of SLC34A2 expression in different types of ovarian tumors |
| title_full | Quantitative analysis of SLC34A2 expression in different types of ovarian tumors |
| title_fullStr | Quantitative analysis of SLC34A2 expression in different types of ovarian tumors |
| title_full_unstemmed | Quantitative analysis of SLC34A2 expression in different types of ovarian tumors |
| title_short | Quantitative analysis of SLC34A2 expression in different types of ovarian tumors |
| title_sort | quantitative analysis of slc34a2 expression in different types of ovarian tumors |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/138632 |
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