Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis

• Published in: Experimental Oncology
• Date: 2011
• Main Authors: Prylutska, S.V., Burlaka, A.P., Prylutskyy, Yu.I., Ritter, U., Scharff, P.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2011
• Subjects: Short communications
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/138636
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis / S.V. Prylutska, A.P. Burlaka, Yu.I. Prylutskyy, U. Ritter, P. Scharff // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 162-164. — Бібліогр.: 22 назв. — англ.

Aim: To estimate the impact of C60 fullerene aqueous solution (C60FAS) on the rate of transplanted malignant tumor growth and metastasis. Methods: Lewis lung carcinoma was transplanted into С57Bl/6J male mice. Conventional methods for the evaluation of antitumor and antimetastatic effects have been used. Results: The C60FAS at low single therapeutic dose of 5 mg/kg inhibited the growth of transplanted malignant tumor (antitumor effect) and metastasis (antimetastatic effect): the maximum therapeutic effect was found to be of 76.5% for the tumor growth inhibition; the increase of animal life span by 22% was found; the metastasis inhibition index was estimated as 48%. Conclusion: It was found that water-soluble pristine С60 fullerenes efficiently inhibit the transplanted malignant tumor growth and metastasis.