Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis
Aim: To estimate the impact of C60 fullerene aqueous solution (C60FAS) on the rate of transplanted malignant tumor growth and metastasis. Methods: Lewis lung carcinoma was transplanted into С57Bl/6J male mice. Conventional methods for the evaluation of antitumor and antimetastatic effects have been...
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| Published in: | Experimental Oncology |
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| Date: | 2011 |
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2011
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/138636 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis / S.V. Prylutska, A.P. Burlaka, Yu.I. Prylutskyy, U. Ritter, P. Scharff // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 162-164. — Бібліогр.: 22 назв. — англ. |
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Prylutska, S.V. Burlaka, A.P. Prylutskyy, Yu.I. Ritter, U. Scharff, P. 2018-06-19T10:47:06Z 2018-06-19T10:47:06Z 2011 Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis / S.V. Prylutska, A.P. Burlaka, Yu.I. Prylutskyy, U. Ritter, P. Scharff // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 162-164. — Бібліогр.: 22 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138636 Aim: To estimate the impact of C60 fullerene aqueous solution (C60FAS) on the rate of transplanted malignant tumor growth and metastasis. Methods: Lewis lung carcinoma was transplanted into С57Bl/6J male mice. Conventional methods for the evaluation of antitumor and antimetastatic effects have been used. Results: The C60FAS at low single therapeutic dose of 5 mg/kg inhibited the growth of transplanted malignant tumor (antitumor effect) and metastasis (antimetastatic effect): the maximum therapeutic effect was found to be of 76.5% for the tumor growth inhibition; the increase of animal life span by 22% was found; the metastasis inhibition index was estimated as 48%. Conclusion: It was found that water-soluble pristine С60 fullerenes efficiently inhibit the transplanted malignant tumor growth and metastasis. This work was partly supported by BMBF grant. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Short communications Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis Article published earlier |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine |
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| title |
Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis |
| spellingShingle |
Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis Prylutska, S.V. Burlaka, A.P. Prylutskyy, Yu.I. Ritter, U. Scharff, P. Short communications |
| title_short |
Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis |
| title_full |
Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis |
| title_fullStr |
Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis |
| title_full_unstemmed |
Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis |
| title_sort |
pristine c60 fullerenes inhibit the rate of tumor growth and metastasis |
| author |
Prylutska, S.V. Burlaka, A.P. Prylutskyy, Yu.I. Ritter, U. Scharff, P. |
| author_facet |
Prylutska, S.V. Burlaka, A.P. Prylutskyy, Yu.I. Ritter, U. Scharff, P. |
| topic |
Short communications |
| topic_facet |
Short communications |
| publishDate |
2011 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Aim: To estimate the impact of C60 fullerene aqueous solution (C60FAS) on the rate of transplanted malignant tumor growth and metastasis. Methods: Lewis lung carcinoma was transplanted into С57Bl/6J male mice. Conventional methods for the evaluation of antitumor and antimetastatic effects have been used. Results: The C60FAS at low single therapeutic dose of 5 mg/kg inhibited the growth of transplanted malignant tumor (antitumor effect) and metastasis (antimetastatic effect): the maximum therapeutic effect was found to be of 76.5% for the tumor growth inhibition; the increase of animal life span by 22% was found; the metastasis inhibition index was estimated as 48%. Conclusion: It was found that water-soluble pristine С60 fullerenes efficiently inhibit the transplanted malignant tumor growth and metastasis.
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/138636 |
| citation_txt |
Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis / S.V. Prylutska, A.P. Burlaka, Yu.I. Prylutskyy, U. Ritter, P. Scharff // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 162-164. — Бібліогр.: 22 назв. — англ. |
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2025-12-07T17:49:04Z |
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2025-12-07T17:49:04Z |
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